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! style="background:#4479BA; color: #FFFFFF;" align="center" + |Risk
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Risk
|-
|-
| rowspan="14" style="background:#DCDCDC;" align="center" + |IMPROVEDD Score
| rowspan="14" style="background:#DCDCDC;" align="center" + |'''IMPROVEDD Score'''<ref>{{cite journal|doi=10.1055/s-0037-160392910.1055/s-0037-1603929}}</ref>
| style="background:#DCDCDC;" align="center" + |
| style="background:#DCDCDC;" align="center" + |
| style="background:#DCDCDC;" align="center" + |Predicted % VTE risk through 42 days
| style="background:#DCDCDC;" align="center" + |Predicted % VTE risk through 42 days
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| style="background:#F5F5F5;" + |2.75
| style="background:#F5F5F5;" + |2.75
|-
|-
| rowspan="7" style="background:#DCDCDC;" align="center" + |IMPROVE score
| rowspan="7" style="background:#DCDCDC;" align="center" + |'''IMPROVE score'''<ref name="pmid21436241">{{cite journal| author=Spyropoulos AC, Anderson FA, Fitzgerald G, Decousus H, Pini M, Chong BH et al.| title=Predictive and associative models to identify hospitalized medical patients at risk for VTE. | journal=Chest | year= 2011 | volume= 140 | issue= 3 | pages= 706-14 | pmid=21436241 | doi=10.1378/chest.10-1944 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21436241  }} </ref>
| style="background:#DCDCDC;" align="center" + |
| style="background:#DCDCDC;" align="center" + |
| style="background:#DCDCDC;" align="center" + |Predicted % VTE risk through 3 months
| style="background:#DCDCDC;" align="center" + |Predicted % VTE risk through 3 months
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| style="background:#F5F5F5;" + |11%  
| style="background:#F5F5F5;" + |11%  
|-
|-
| rowspan="2" style="background:#DCDCDC;" align="center" + | Padua Score
| rowspan="2" style="background:#DCDCDC;" align="center" + | '''Padua Score'''<ref name="pmid20738765">{{cite journal| author=Barbar S, Noventa F, Rossetto V, Ferrari A, Brandolin B, Perlati M et al.| title=A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score. | journal=J Thromb Haemost | year= 2010 | volume= 8 | issue= 11 | pages= 2450-7 | pmid=20738765 | doi=10.1111/j.1538-7836.2010.04044.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20738765  }} </ref>
| style="background:#F5F5F5;" align="center" + |< 4
| style="background:#F5F5F5;" align="center" + |< 4
| style="background:#F5F5F5;" + |Low risk for VTE
| style="background:#F5F5F5;" + |Low risk for VTE
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| style="background:#F5F5F5;" + |High risk for VTE
| style="background:#F5F5F5;" + |High risk for VTE
|-
|-
| rowspan="4" style="background:#DCDCDC;" align="center" + |Caprini score
| rowspan="4" style="background:#DCDCDC;" align="center" + |'''Caprini score'''<ref name="pmid1754886">{{cite journal| author=Caprini JA, Arcelus JI, Hasty JH, Tamhane AC, Fabrega F| title=Clinical assessment of venous thromboembolic risk in surgical patients. | journal=Semin Thromb Hemost | year= 1991 | volume= 17 Suppl 3 | issue=  | pages= 304-12 | pmid=1754886 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1754886  }} </ref>
| style="background:#F5F5F5;" align="center" + |0-1
| style="background:#F5F5F5;" align="center" + |0-1
| style="background:#F5F5F5;" + |Low risk of VTE
| style="background:#F5F5F5;" + |Low risk of VTE

Revision as of 14:02, 16 October 2017

Historical Perspective

Discovery

  • In 1869, Paul Langerhans first described pancreatic islet cells, when he was still a medical student.
  • In 1902, Nicholls discovered the first adenoma of pancreatic islets.[1]
  • In 1922, Frederick Banting and Charles Best were the first to discover insulin from a dog’s pancreas.
  • In 1926, Wilder-et-al associated hyperinsulinism and functional islet tumor after a surgery on a person who had hypoglycemia and found an islet cell cancer with liver metastasis.[2]
  • In 1927, William J Mayo was the first to discover the association between hyperinsulinism and a functional pancreatic islet cell tumor. In 1927, the insulinoma was first described in Mayo clinic, which was dissected in 1929 in Toronto.[1]
  • In 1929, the first surgical cure was performed by Roscoe Graham.[3]


Risk assessment table

Scoring criteria for risk assessment*
Scoring system Score Risk
IMPROVEDD Score[4] Predicted % VTE risk through 42 days
0 0.4%
1 0.6%
2 0.8%
3 1.2%
4 1.6%
5-10 2.2%
Predicted % VTE risk through 77 days
0 0.5%
1 0.7%
2 1.0%
3 1.4%
4 1.9%
5-10 2.75
IMPROVE score[5] Predicted % VTE risk through 3 months
0 0.5%
1 1.0%
2 1.7%
3 3.1%
4 4%
5-8 11%
Padua Score[6] < 4 Low risk for VTE
≥ 4 High risk for VTE
Caprini score[7] 0-1 Low risk of VTE
2 Moderate of VTE
3-4 High risk of VTE
≥ 5 Highest risk for VTE

References

  1. 1.0 1.1 Stamatakos M, Safioleas C, Tsaknaki S, Safioleas P, Iannescu R, Safioleas M (2009). "Insulinoma: a rare neuroendocrine pancreatic tumor". Chirurgia (Bucur). 104 (6): 669–73. PMID 20187464.
  2. Wilder, Russell M.; Allan, Frank N.; Power, M. H.; Robertson, H. E. (1927). "CARCINOMA OF THE ISLANDS OF THE PANCREAS". Journal of the American Medical Association. 89 (5): 348. doi:10.1001/jama.1927.02690050014007. ISSN 0002-9955.
  3. 3.0 3.1 Whipple AO, Frantz VK (1935). "ADENOMA OF ISLET CELLS WITH HYPERINSULINISM: A REVIEW". Ann. Surg. 101 (6): 1299–335. PMC 1390871. PMID 17856569.
  4. . doi:10.1055/s-0037-160392910.1055/s-0037-1603929. Missing or empty |title= (help)
  5. Spyropoulos AC, Anderson FA, Fitzgerald G, Decousus H, Pini M, Chong BH; et al. (2011). "Predictive and associative models to identify hospitalized medical patients at risk for VTE". Chest. 140 (3): 706–14. doi:10.1378/chest.10-1944. PMID 21436241.
  6. Barbar S, Noventa F, Rossetto V, Ferrari A, Brandolin B, Perlati M; et al. (2010). "A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score". J Thromb Haemost. 8 (11): 2450–7. doi:10.1111/j.1538-7836.2010.04044.x. PMID 20738765.
  7. Caprini JA, Arcelus JI, Hasty JH, Tamhane AC, Fabrega F (1991). "Clinical assessment of venous thromboembolic risk in surgical patients". Semin Thromb Hemost. 17 Suppl 3: 304–12. PMID 1754886.