Polycystic ovary syndrome differential diagnosis: Difference between revisions
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==Overview== | ==Overview== | ||
Polycystic ovary syndrome must be differentiated from other causes of irregular or absent menstruation and hirsutism, such as [[congenital adrenal hyperplasia]], [[cushing's syndrome]], [[hyperprolactinemia]], and other pituitary or adrenal disorders. | Polycystic ovary syndrome must be differentiated from other causes of irregular or absent [[menstruation]] and [[hirsutism]], such as [[congenital adrenal hyperplasia]], [[cushing's syndrome]], [[hyperprolactinemia]], and other [[pituitary]] or [[adrenal]] disorders. | ||
==Differentiating Polycystic ovary syndrome from other Diseases== | ==Differentiating Polycystic ovary syndrome from other Diseases== | ||
Polycystic ovary syndrome must be differentiated from other causes of irregular or absent menstruation and hirsutism, such as [[congenital adrenal hyperplasia]], [[cushing's syndrome]], [[hyperprolactinemia]], and other pituitary or | Polycystic ovary syndrome must be differentiated from other causes of irregular or absent [[menstruation]] and [[hirsutism]], such as [[congenital adrenal hyperplasia]], [[cushing's syndrome]], [[hyperprolactinemia]], and other [[pituitary]] or [[Adrenal|adrena]]<nowiki/>l disorders. The table below summarizes the findings that differentiate polycystic ovary syndrome from other conditions that cause irregular or absent [[menstruation]] and [[hirsutism]]:<ref name="pmid11253984">{{cite journal |vauthors=Boscaro M, Barzon L, Fallo F, Sonino N |title=Cushing's syndrome |journal=Lancet |volume=357 |issue=9258 |pages=783–91 |year=2001 |pmid=11253984 |doi=10.1016/S0140-6736(00)04172-6 |url=}}</ref><ref name="pmid11571938">{{cite journal |vauthors=Findling JW, Raff H |title=Diagnosis and differential diagnosis of Cushing's syndrome |journal=Endocrinol. Metab. Clin. North Am. |volume=30 |issue=3 |pages=729–47 |year=2001 |pmid=11571938 |doi= |url=}}</ref><ref name="pmid9793762">{{cite journal |vauthors=Newell-Price J, Trainer P, Besser M, Grossman A |title=The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states |journal=Endocr. Rev. |volume=19 |issue=5 |pages=647–72 |year=1998 |pmid=9793762 |doi=10.1210/edrv.19.5.0346 |url=}}</ref><ref name="urlHow Is Metabolic Syndrome Diagnosed? - NHLBI, NIH">{{cite web |url=https://www.nhlbi.nih.gov/health/health-topics/topics/ms/diagnosis |title=How Is Metabolic Syndrome Diagnosed? - NHLBI, NIH |format= |work= |accessdate=}}</ref> | ||
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!Disease | !Disease | ||
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* When secondary to medications, the excessive hair is of new onset, and other features of virilization, such as [[acne]] and deepened voice, may be present | * When secondary to medications, the excessive hair is of new onset, and other features of virilization, such as [[acne]] and deepened voice, may be present | ||
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===Other differentials=== | ===Other differentials=== |
Revision as of 16:13, 18 October 2017
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Differentiating Polycystic ovary syndrome from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]
Overview
Polycystic ovary syndrome must be differentiated from other causes of irregular or absent menstruation and hirsutism, such as congenital adrenal hyperplasia, cushing's syndrome, hyperprolactinemia, and other pituitary or adrenal disorders.
Differentiating Polycystic ovary syndrome from other Diseases
Polycystic ovary syndrome must be differentiated from other causes of irregular or absent menstruation and hirsutism, such as congenital adrenal hyperplasia, cushing's syndrome, hyperprolactinemia, and other pituitary or adrenal disorders. The table below summarizes the findings that differentiate polycystic ovary syndrome from other conditions that cause irregular or absent menstruation and hirsutism:[1][2][3][4]
Disease | Differentiating Features |
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Pregnancy |
|
Hypothalamic amenorrhea |
|
Primary amenorrhea |
|
Cushing syndrome |
|
Hyperprolactinemia |
|
Ovarian or adrenal tumor |
|
Congenital adrenal hyperplasia |
|
Anabolic steroid abuse |
|
Hirsutism |
|
Other differentials
Polycystic ovarian syndrome must be differentiated from diseases that cause virilization and hirsutism in female:[5][6][7]
Disease name | Steroid status | Other laboratory | Important clinical findings |
---|---|---|---|
Non-classic type of 21-hydroxylase deficiency | Increased:
|
|
|
11-β hydroxylase deficiency | Increased:
Decreased: |
|
|
3 beta-hydroxysteroid dehydrogenase deficiency | Increased:
Decreased: |
|
|
Polycystic ovary syndrome |
|
|
|
Adrenal tumors |
|
|
|
Ovarian virilizing tumor |
|
|
|
Cushing's syndrome |
|
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Hyperprolactinemia |
|
|
References
- ↑ Boscaro M, Barzon L, Fallo F, Sonino N (2001). "Cushing's syndrome". Lancet. 357 (9258): 783–91. doi:10.1016/S0140-6736(00)04172-6. PMID 11253984.
- ↑ Findling JW, Raff H (2001). "Diagnosis and differential diagnosis of Cushing's syndrome". Endocrinol. Metab. Clin. North Am. 30 (3): 729–47. PMID 11571938.
- ↑ Newell-Price J, Trainer P, Besser M, Grossman A (1998). "The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states". Endocr. Rev. 19 (5): 647–72. doi:10.1210/edrv.19.5.0346. PMID 9793762.
- ↑ "How Is Metabolic Syndrome Diagnosed? - NHLBI, NIH".
- ↑ Hohl A, Ronsoni MF, Oliveira M (2014). "Hirsutism: diagnosis and treatment". Arq Bras Endocrinol Metabol. 58 (2): 97–107. PMID 24830586. Vancouver style error: initials (help)
- ↑ White PC, Speiser PW (2000). "Congenital adrenal hyperplasia due to 21-hydroxylase deficiency". Endocr. Rev. 21 (3): 245–91. doi:10.1210/edrv.21.3.0398. PMID 10857554.
- ↑ Melmed, Shlomo (2016). Williams textbook of endocrinology. Philadelphia, PA: Elsevier. ISBN 978-0323297387.=