Thyroid nodule differential diagnosis: Difference between revisions
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!FT4/T3 | !FT4/T3 | ||
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! rowspan="8" |<small> <small> Benign </small> </small> | ! rowspan="8" |<small> <small> Benign </small> </small>PMC3575959 | ||
PMC2879398 | |||
PMC3811718 | |||
!Colloid adenoma | !Colloid adenoma | ||
| | | | ||
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|↑↓ | |↑↓ | ||
|- | |- | ||
! rowspan="6" | <small> <small> Malignant </small> </small> | ! rowspan="6" | <small> <small> Malignant</small></small><small><small>PMC4415174</small></small> | ||
PMC1587522 | |||
21222366 | |||
<small><small> </small> 27075347 </small> | |||
PMC5024877 | |||
![[Papillary carcinoma of the thyroid|Papillary carcinoma]] | ![[Papillary carcinoma of the thyroid|Papillary carcinoma]] | ||
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! colspan="2" |[[Thyroglossal duct cyst]] | ! colspan="2" |[[Thyroglossal duct cyst]] | ||
22338239 | |||
| | | | ||
* Mostly midline | * Mostly midline | ||
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|- | |- | ||
! colspan="2" |[[Branchial cleft cyst]] | ! colspan="2" |[[Branchial cleft cyst]] | ||
PMC5122306 | |||
| | | | ||
* Cystic mass that develops under the skin in the neck between the [[sternocleidomastoid muscle]] and the [[pharynx]] | * Cystic mass that develops under the skin in the neck between the [[sternocleidomastoid muscle]] and the [[pharynx]] | ||
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|- | |- | ||
! colspan="2" |[[Neck masses|Neck abscess]] | ! colspan="2" |[[Neck masses|Neck abscess]] | ||
PMC5175110 | |||
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* Painful mass in the neck, may be accompanied with [[erythema]] | * Painful mass in the neck, may be accompanied with [[erythema]] | ||
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|- | |- | ||
! colspan="2" |Parathyroid cyst | ! colspan="2" |Parathyroid cyst | ||
17180630 | |||
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* Painless mass | * Painless mass |
Revision as of 13:41, 20 October 2017
Thyroid nodule Microchapters |
Diagnosis |
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Treatment |
Case Studies |
Thyroid nodule differential diagnosis On the Web |
American Roentgen Ray Society Images of Thyroid nodule differential diagnosis |
Risk calculators and risk factors for Thyroid nodule differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]
Overview
Neck masses can be mistaken with thyroid nodules. The most important neck masses that can be mistaken with thyroid nodules include: Thyroglossal duct cyst, Parathyroid cancer, parathyroid cyst, Branchial cleft cyst. While the diagnosis of a thyroid nodule is established, thyroid nodule should be differentiated based on benign or malignant features and the type of nodule.
Thyroid nodule differential diagnosis
Neck masses can be mistaken with thyroid nodules. While the diagnosis of a thyroid nodule is established, thyroid nodule should be differentiated based on benign or malignant features and the type of nodule:
Disease | Nodule property | Spread | Nodular growth | Laboratory | Imaging | Pathology | Associated mutation | special consideration | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
LN | Vessle | Metastasis | TSH | FT4/T3 | ||||||||
Benign PMC3575959
PMC2879398 PMC3811718 |
Colloid adenoma |
|
- | - | - | Intermediate
Slow |
NL | NL |
|
|
--- | May progress to carcinoma |
Hashimoto's thyroiditis |
|
- | - | - | Rapid
Intermediate |
↓↓ | ↓ |
|
|
May be accompanied with fever | ||
Cysts nodule |
|
- | - | - | Rapid
Intermediate |
NL | NL |
|
- | Mostly due to degenerating thyroid adenomas | ||
Follicular adenoma |
|
- | - | - | Intermediate
Slow |
↓↓ | ↑ |
|
--- |
|
--- | |
Hyperplastic nodule | - | - | - | Rapid
Intermediate |
↓↓ | ↑ | ||||||
Macrofollicular adenoma | - | - | - | Intermediate
Slow |
↓↓ | ↑ | ||||||
Microfollicular or cellular adenoma | - | - | - | Intermediate
Slow |
↓↓ | ↑ | ||||||
Hürthle cell adenoma | - | - | - | Intermediate
Slow |
↑↓ | ↑↓ | ||||||
MalignantPMC4415174
PMC1587522 21222366 27075347 PMC5024877 |
Papillary carcinoma |
|
+ | + |
|
Intermediate
Slow |
NL | NL |
|
|
--- | |
Follicular carcinoma |
|
+ | + |
|
Intermediate
Slow |
↑↓ | ↑↓ |
|
|
|
| |
Medullary carcinoma | Mainly manifest paraneoplastic symptoms: | + | -/+ |
|
Intermediate
Slow |
NL | NL |
|
|
--- |
| |
Anaplastic carcinoma | + | + | Slow | ↓ | ↑ |
|
Cytologically malignant:
|
|
| |||
Primary thyroid lymphoma | + | - |
|
Intermediate
Slow |
NL | NL |
|
|
|
| ||
Metastatic carcinoma |
|
+ | + | + | Intermediate
Slow |
↑↓ | ↑↓ | - | - | - | ||
Thyroglossal duct cyst
22338239 |
|
- | - | --- | --- | NL | NL |
|
--- | --- | --- | |
Branchial cleft cyst
PMC5122306 |
|
- | +
May adhere to great vessels at the mandibular angle |
--- | --- | NL | NL |
|
--- | --- | --- | |
Neck abscess
PMC5175110 |
|
+ | - | --- | Rapid | NL | NL |
|
--- | --- | --- | |
Parathyroid cyst
17180630 |
|
- | - | --- | Rapid
Intermediate |
NL | NL |
|
--- | --- | --- | |
Parathyroid cancer
PMC3059245 |
|
+ | + | +
Rarely distant metastases, mainly thyroid gland, overlying strap muscles, recurrent laryngeal nerve, trachea, or esophagus |
Slow
Intermediate |
NL | NL |
|
|
|
--- |