Adult T-cell leukemia differential diagnosis: Difference between revisions

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==Overview==
==Overview==
Adult T-cell leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].<ref name=wiki>Adult T-cell leukemia/lymphoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Adult_T-cell_leukemia/lymphoma Accessed on November, 3 2015</ref><ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
Adult T-cell leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].


==Differenting Adult T-cell Leukemia from other Diseases==
==Differentiating Adult T-cell Leukemia from other Diseases==
* Adult T-cell leukemia must be differentiated from other diseases that cause [[weight loss]], [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].<ref name=wiki>Adult T-cell leukemia/lymphoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Adult_T-cell_leukemia/lymphoma Accessed on November, 3 2015</ref><ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
* Adult T-cell leukemia must be differentiated from other diseases that cause [[weight loss]], [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].<ref name="wiki">Adult T-cell leukemia/lymphoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Adult_T-cell_leukemia/lymphoma Accessed on November, 3 2015</ref><ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
* Based on the expression of cell surface markers, the table below differentiates adult T-cell leukemia from other diseases that cause similar clinical presentations:
* Based on the expression of cell surface markers, the table below differentiates adult T-cell leukemia from other diseases that cause similar clinical presentations:
<br>
{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
|valign=top|
 
|+
|+
! style="background: #4479BA; width: 600px;" | {{fontcolor|#FFF|'''Differential Diagnosis'''}}
! style="background: #4479BA; width: 600px;" | {{fontcolor|#FFF|'''Differential Diagnosis'''}}
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Chronic lymphocytic leukemia'''
'''Chronic lymphocytic leukemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center |
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Weakly positive'''
Weakly positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center |
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Positive'''
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center |
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Negative'''
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Positive'''
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Negative'''
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Positive/Negative'''
Positive/Negative


|-
|-
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Prolymphocytic leukemia'''
'''Prolymphocytic leukemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Strongly positive'''
Strongly positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Negative'''
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Positive'''
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Negative'''
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Positive'''
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Negative'''
Negative


|-
|-
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Hairy cell leukemia'''
'''Hairy cell leukemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Strongly positive'''
Strongly positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Negative'''
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Positive'''
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Negative'''
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Positive/Negative'''
Positive/Negative
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Positive'''
Positive


|-
|-
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Mantle cell lymphoma'''
'''Mantle cell lymphoma'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Positive'''
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Positive'''
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Strongly positive'''
Strongly positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Negative'''
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Strongly positive'''
Strongly positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Negative'''
Negative


|-
|-
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Follicular lymphoma'''
'''Follicular lymphoma'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Strongly positive'''
Strongly positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Negative'''
Negative  
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Positive'''
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Negative'''
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Strongly positive'''
Strongly positive
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
'''Negative'''
Negative
|}
|}
<br>
<br>
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{{WH}}
{{WH}}
{{WS}}
{{WS}}


[[Category:Disease]]
[[Category:Disease]]

Revision as of 00:32, 2 November 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Adult T-cell leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.

Differentiating Adult T-cell Leukemia from other Diseases

Differential Diagnosis Surface Immunoglobulin CD5 CD22/FMC7 CD23 CD79b CD103

Chronic lymphocytic leukemia

Weakly positive

Positive

Negative

Positive

Negative

Positive/Negative

Prolymphocytic leukemia

Strongly positive

Negative

Positive

Negative

Positive

Negative

Hairy cell leukemia

Strongly positive

Negative

Positive

Negative

Positive/Negative

Positive

Mantle cell lymphoma

Positive

Positive

Strongly positive

Negative

Strongly positive

Negative

Follicular lymphoma

Strongly positive

Negative

Positive

Negative

Strongly positive

Negative


References

  1. ↑ Adult T-cell leukemia/lymphoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Adult_T-cell_leukemia/lymphoma Accessed on November, 3 2015
  2. ↑ Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011

Template:WH Template:WS

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