Whipple's disease historical perspective: Difference between revisions
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|1907 | |1907 | ||
|George Hoyt Whipple | |George Hoyt Whipple | ||
| | |Described the Whipple's disease for the first time and named it as "[[intestinal lipodystrophy]]" | ||
|- | |- | ||
|1947 | |1947 | ||
|Oliver-Pascual et al. | |Oliver-Pascual et al. | ||
| | |Reported a case of “[[intestinal lipodystrophy]]” before the death of a patient | ||
|- | |- | ||
|1949 | |1949 | ||
|Black-Schaffer | |Black-Schaffer | ||
| | |Strained the [[bacilli]] with [[periodic acid-Schiff stain]]; renamed to "Whipple's disease" | ||
|- | |- | ||
|1952 | |1952 | ||
|Pauley | |Pauley | ||
| | |Successfully used systemic [[Antibiotic|antibiotics]] for treatment of the "Whipple's disease" | ||
|- | |- | ||
|1958 | |1958 | ||
|Bolt et al. | |Bolt et al. | ||
| | |Used small bowel [[biopsy]] to differentiate [[malabsorption]] diseases and confirm the Whipple's disease | ||
|- | |- | ||
|1961 | |1961 | ||
|Chears and Ashworth | |Chears and Ashworth | ||
| | |Used [[Electron microscope|electron microscopy]] and cytochemical study to detect the [[bacilli]] inside the intestinal [[Macrophage|macrophages]] | ||
|- | |- | ||
|1961 | |1961 | ||
|Yardley and Hendrix | |Yardley and Hendrix | ||
| | |Used combined electron and [[light microscopy]] to detect the rod-shaped structures in the intestinal [[mucosa]] | ||
|- | |- | ||
|1991 | |1991 | ||
|Wilson et al. | |Wilson et al. | ||
| | |Sequenced a 16S rRNA of a new [[bacterium]] partially and classified it within the [[Actinobacteria|Actinomycetes]] clade | ||
|- | |- | ||
|1992 | |1992 | ||
|Relman et al. | |Relman et al. | ||
| | |Confirmed the previous result and extended the 16S rRNA sequence by using [[Polymerase chain reaction|PCR]]; named the bacterium “[[Tropheryma whipplei|Tropheryma whippleii]]” for the first time | ||
|- | |- | ||
|2000 | |2000 | ||
|Raoult et al. | |Raoult et al. | ||
| | |Reported isolation and cultivation of “[[Tropheryma whipplei|Tropheryma whippleii]]” for the first time | ||
|- | |- | ||
|2001 | |2001 | ||
|La Scola et al. | |La Scola et al. | ||
| | |Characterized the [[bacterium]] phenotypically; slightly renamed it to “[[Tropheryma whipplei]]” | ||
|- | |- | ||
|2003 | |2003 | ||
|Bentley et al. | |Bentley et al. | ||
Raoult et al. | Raoult et al. | ||
| | |Analyzed and sequenced the [[genome]] of two different strains of [[Tropheryma whipplei|T. whipplei]] | ||
|} | |} | ||
Revision as of 19:26, 25 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
Historical Perspective
- George Hoyt Whipple in 1907, described a case who died after a course of gastrointestinal, malabsorption, pulmonary, neurologic and constitutional symptoms. Pathology showed rod-like bacilli in the lamina propria and fat deposition in intestinal and mesenteric lymph nodes. He named this disease as “intestinal lipodystrophy.”[1]
- In 1947, Oliver-Pascual et al. reported a case of “intestinal lipodystrophy” before the death of a patient. [2]
- “Intestinal lipodystrophy” was renamed to “Whipple’s disease” in 1949, after the development of periodic acid-Schiff for staining the bacilli by Black-Schaffer.[3]
- Pauley in 1952 treated a patient successfully by using systemic antibiotics, prolonged period of Chloramphenicol.[4]
- In 1958, Bolt et al. reported the use of the small-bowel biopsy to differentiate malabsorption diseases and confirm the Whipple's disease.[5]
- In 1961, Chears and Ashworth used electron microscopy and cytochemical study to detect the bacilli inside the intestinal macrophages. [6] In that year, another team, Yardley and Hendrix demonstrated the rod-shaped structures in the intestinal mucosa by combined electron and light microscopy.[7]
- Wilson and his team in 1991, were able to partially sequence a 16S rRNA of a new bacterium. They classified this bacterium within the Actinomycetes clade.[8]
- In 1992, Relman et al. confirmed the previous result and extended the 16S rRNA sequence by using PCR. They used the term of “Tropheryma whippleii” for the first time for this bacterium. [9]
- In 2000, Raoult et al. reported isolation and cultivation of the bacterium responsible for the Whipple's disease. They obtained the tissue from the mitral valve of a patient with a culture negative endocarditis.[10]
- In 2001 La Scola et al. isolated Whipple’s disease bacillus from the cardiac valve of a patient with endocarditis and characterized it phenotypically. They slightly changed the name to “T. whipplei.” [11]
- In 2003, Bentley et al. and Raoult et al. analyzed and sequenced the genome of two different strains of T. whipplei. [12] [13]
| Year | Investigator | Landmark event |
|---|---|---|
| 1907 | George Hoyt Whipple | Described the Whipple's disease for the first time and named it as "intestinal lipodystrophy" |
| 1947 | Oliver-Pascual et al. | Reported a case of “intestinal lipodystrophy” before the death of a patient |
| 1949 | Black-Schaffer | Strained the bacilli with periodic acid-Schiff stain; renamed to "Whipple's disease" |
| 1952 | Pauley | Successfully used systemic antibiotics for treatment of the "Whipple's disease" |
| 1958 | Bolt et al. | Used small bowel biopsy to differentiate malabsorption diseases and confirm the Whipple's disease |
| 1961 | Chears and Ashworth | Used electron microscopy and cytochemical study to detect the bacilli inside the intestinal macrophages |
| 1961 | Yardley and Hendrix | Used combined electron and light microscopy to detect the rod-shaped structures in the intestinal mucosa |
| 1991 | Wilson et al. | Sequenced a 16S rRNA of a new bacterium partially and classified it within the Actinomycetes clade |
| 1992 | Relman et al. | Confirmed the previous result and extended the 16S rRNA sequence by using PCR; named the bacterium “Tropheryma whippleii” for the first time |
| 2000 | Raoult et al. | Reported isolation and cultivation of “Tropheryma whippleii” for the first time |
| 2001 | La Scola et al. | Characterized the bacterium phenotypically; slightly renamed it to “Tropheryma whipplei” |
| 2003 | Bentley et al.
Raoult et al. |
Analyzed and sequenced the genome of two different strains of T. whipplei |
Landmark Events in the Development of Treatment Strategies
- Pauley in 1952 treated a Whipple's disease successfully by using systemic antibiotics, prolonged period of Chloramphenicol.[4]
References
- ↑ Whipple G H. A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues. Bull Johns Hopkins Hosp. 1907;198:383.
- ↑ OLIVER-PASCUAL E, GALAN J (1947). "[Not Available]". Rev Esp Enferm Apar Dig Nutr (in Undetermined). 6 (3): 213–26. PMID 20251637.
- ↑ BLACK-SCHAFFER B (1949). "The tinctoral demonstration of a glycoprotein in Whipple's disease". Proc. Soc. Exp. Biol. Med. 72 (1): 225–7. PMID 15391722.
- ↑ 4.0 4.1 PAULLEY JW (1952). "A case of Whipple's disease (intestinal lipodystrophy)". Gastroenterology. 22 (1): 128–33. PMID 12980233.
- ↑ Bolt, Robert J.; Pollard, H. Marvin; Standaert, Ludovic (1958). "Transoral Small-Bowel Biopsy as an Aid in the Diagnosis of Malabsorption States". New England Journal of Medicine. 259 (1): 32–34. doi:10.1056/NEJM195807032590107. ISSN 0028-4793.
- ↑ CHEARS WC, ASHWORTH CT (1961). "Electron microscopic study of the intestinal mucosa in Whipple's disease. Demonstration of encapsulated bacilliform bodies in the lesion". Gastroenterology. 41: 129–38. PMID 13692693.
- ↑ YARDLEY JH, HENDRIX TR (1961). "Combined electron and light microscopy in Whipple's disease. Demonstration of "bacillary bodies" in the intestine". Bull Johns Hopkins Hosp. 109: 80–98. PMID 13787237.
- ↑ Wilson KH, Blitchington R, Frothingham R, Wilson JA (1991). "Phylogeny of the Whipple's-disease-associated bacterium". Lancet. 338 (8765): 474–5. PMID 1714530.
- ↑ Relman, David A.; Schmidt, Thomas M.; MacDermott, Richard P.; Falkow, Stanley (1992). "Identification of the Uncultured Bacillus of Whipple's Disease". New England Journal of Medicine. 327 (5): 293–301. doi:10.1056/NEJM199207303270501. ISSN 0028-4793.
- ↑ Raoult, Didier; Birg, Marie L.; Scola, Bernard La; Fournier, Pierre E.; Enea, Maryse; Lepidi, Hubert; Roux, Veronique; Piette, Jean-Charles; Vandenesch, François; Vital-Durand, Denis; Marrie, Tom J. (2000). "Cultivation of the Bacillus of Whipple's Disease". New England Journal of Medicine. 342 (9): 620–625. doi:10.1056/NEJM200003023420903. ISSN 0028-4793.
- ↑ La Scola, B; Altwegg, M; Mallet, M N; Fournier, P E; Fenollar, F; Raoult, D (2001). "Description of Tropheryma whipplei gen. nov., sp. nov., the Whipple's disease bacillus". International Journal of Systematic and Evolutionary Microbiology. 51 (4): 1471–1479. doi:10.1099/00207713-51-4-1471. ISSN 1466-5026.
- ↑ Bentley, Stephen D; Maiwald, Matthias; Murphy, Lee D; Pallen, Mark J; Yeats, Corin A; Dover, Lynn G; Norbertczak, Halina T; Besra, Gurdyal S; Quail, Michael A; Harris, David E; von Herbay, Axel; Goble, Arlette; Rutter, Simon; Squares, Robert; Squares, Stephen; Barrell, Bart G; Parkhill, Julian; Relman, David A (2003). "Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei". The Lancet. 361 (9358): 637–644. doi:10.1016/S0140-6736(03)12597-4. ISSN 0140-6736.
- ↑ Raoult D, Ogata H, Audic S, Robert C, Suhre K, Drancourt M, Claverie JM (2003). "Tropheryma whipplei Twist: a human pathogenic Actinobacteria with a reduced genome". Genome Res. 13 (8): 1800–9. doi:10.1101/gr.1474603. PMC 403771. PMID 12902375.