Sandbox: Ventricular Arrhythmias ACC -2017

Template:Ventricular Arrhythmias ACC -2017 Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1],Associate Editor(s)-in-Chief: Arzu Kalayci, M.D. [2]

2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death

History and Physical Examination

Class I

"1. Patients presenting with syncope for which VA is documented, or thought to be a likely cause, should be hospitalized for evaluation, monitoring, and management. (Level of Evidence: B-NR) "

12-lead ECG and Exercise Testing

Class I

"1. In patients with sustained, hemodynamically stable, wide complex tachycardia, a 12-lead ECG during tachycardia should be obtained. (Level of Evidence: B-NR) "

"2. In patients with VA symptoms associated with exertion, suspected ischemic heart disease, or catecholaminergic polymorphic ventricular tachycardia, exercise treadmill testing is useful to assess for exercise-induced VA. (Level of Evidence: B-NR) "

"3. In patients with suspected or documented VA, a 12-lead ECG should be obtained in sinus rhythm to look for evidence of heart disease. (Level of Evidence: B-NR) "

Ambulatory Electrocardiography

"1. Ambulatory electrocardiographic monitoring is useful to evaluate whether symptoms, including palpitations, presyncope, or syncope, are caused by VA. (Level of Evidence: B-NR) "

Implanted Cardiac Monitors

Class IIa

"1. In patients with sporadic symptoms (including syncope) suspected to be related to VA, implanted cardiac monitors can be useful. (Level of Evidence: B-R) "

Noninvasive Cardiac Imaging

Class I

"1. In patients with known or suspected VA that may be associated with underlying structural heart disease or a risk of SCA, echocardiography is recommended for evaluation of cardiac structure and function. (Level of Evidence: B-NR) "

Class IIa

"1. In patients presenting with VA who are suspected of having structural heart disease, cardiac magnetic resonance imaging (MRI) or computed tomography (CT) can be useful to detect and characterize underlying structural heart disease. (Level of Evidence: C-EO) "

Biomarkers

Class IIa

"1. In patients presenting with VA who are suspected of having structural heart disease, cardiac magnetic resonance imaging (MRI) or computed tomography (CT) can be useful to detect and characterize underlying structural heart disease. (Level of Evidence: B-NR) "

Genetic Considerations in Arrhythmia Syndromes

Class I

"1. In patients and family members in whom genetic testing for risk stratification for SCA or SCD is recommended, genetic counselling in beneficial. (Level of Evidence: C-EO) "

Invasive Cardiac Imaging: Cardiac Catheterization or CT Angiography

"1. In patients who have recovered from unexplained SCA, CT or invasive coronary angiography is useful to confirm the presence or absence of ischemic heart disease and guide decisions for myocardial revascularization. (Level of Evidence: C-EO) "

Electrophysiological Study for VA

Class IIa

"1. In patients with ischemic cardiomyopathy, NICM, or adult congenital heart disease who have syncope or other VA symptoms and who do not meet indications for a primary prevention ICD, an electrophysiological study can be useful for assessing the risk of sustained VT. (Level of Evidence: B-R) "

Class III - No Benefit

"1. In patients who meet criteria for ICD implantation, an electrophysiological study for the sole reason of inducing VA is not indicated for risk stratification. (Level of Evidence: B-R) "

"1. In patients who meet criteria for ICD implantation, an electrophysiological study for the sole reason of inducing VA is not indicated for risk stratification. (Level of Evidence: B-NR) "

Preventing SCD With HF Medications

Class I

"1. In patients with HFrEF (LVEF ≤40%), treatment with a beta blocker, a mineralocorticoid receptor antagonist and either an angiotensin-converting enzyme inhibitor, an angiotensin-receptor blocker, or an angiotensin receptor- neprilysin inhibitor is recommended to reduce SCD and all-cause mortality. (Level of Evidence: A) "

Surgery and Revascularization Procedures in Patients With Ischemic Heart Disease

Class I

"1. Patients with sustained VA and survivors of SCA should be evaluated for ischemic heart disease, and should be revascularized as appropriate. (Level of Evidence: B-NR) "

"1. In patients with anomalous origin of a coronary artery suspected to be the cause of SCA, repair or revascularization is recommended. (Level of Evidence: C-EO) "

Surgery for Arrhythmia Management

Class IIb

"1. In patients with monomorphic VT refractory to antiarrhythmic medications and attempts at catheter ablation, surgical ablation may be reasonable. (Level of Evidence: C-LD) "

Autonomic Modulation

Class IIa

"1. In patients with symptomatic, non–life-threatening VA, treatment with a beta blocker is reasonable. (Level of Evidence: C-LD) "

Class IIb

"1. In patients with VT/VF storm in whom a beta blocker, other antiarrhythmic medications, and catheter ablation are ineffective, not tolerated, or not possible, cardiac sympathetic denervation may be reasonable. (Level of Evidence: C-LD) "

Acute Management of Specific Ventricular Arrhythmia

Recommendations for Management of Cardiac Arrest

Class I

"1. CPR should be performed in patients in cardiac arrest. according to published basic and advanced cardiovascular life support algorithms. (Level of Evidence: A) "

"2. In patients with hemodynamically unstable VA that persist or recur after a maximal energy shock, intravenous amiodarone should be administered to attempt to achieve a stable rhythm after further defibrillation. (Level of Evidence: A) "

"3. Patients presenting with VA with hemodynamic instability should undergo direct current cardioversion. (Level of Evidence: A) "

"4. In patients with polymorphic VT or VF with ST-elevation MI, angiography with emergency revascularization is recommended. (Level of Evidence: B-NR) "

"5. Patients with a wide-QRS tachycardia should be presumed to have VT if the diagnosis is unclear. (Level of Evidence: C-EO) "

Class IIa

"1. In patients with hemodynamically stable VT, administration of intravenous procainamide can be useful to attempt to terminate VT. (Level of Evidence: A) "

"2. In patients with a witnessed cardiac arrest due to VF or polymorphic VT that is unresponsive to CPR, defibrillation, and vasopressor therapy, intravenous lidocaine can be beneficia. (Level of Evidence: B-R) "

"3. In patients with polymorphic VT due to myocardial ischemia, intravenous beta blockers can be useful. (Level of Evidence: B-R) "

"4. In patients with a recent MI who have VT/VF that repeatedly recurs despite direct current cardioversion and antiarrhythmic medications (VT/VF storm), an intravenous beta blocker can be useful. (Level of Evidence: B-NR) "

Class IIb

"1. In patients in cardiac arrest, administration of epinephrine (1 mg every 3 to 5 minutes) during CPR may be reasonable. (Level of Evidence: A) "

"2. In patients with hemodynamically stable VT, administration of intravenous amiodarone or sotalol may be considered to attempt to terminate VT. (Level of Evidence: B-R) "

Class III - No Benefit

"1. In patients with cardiac arrest,administration of high-dose epinephrine (>1mg boluses) compared with standard doses is not beneficial. (Level of Evidence: A) "

"2. In patients with cardiac arrest,administration of high-dose epinephrine (>1mg boluses) compared with standard doses is not beneficial. (Level of Evidence: A) "

Class III - Harm

"3. In patients with suspected AMI, prophylactic administration of lidocaine or high dose amiodarone for the prevention of VT is potentially harmful. (Level of Evidence: B-R) "

"4. In patients with a wide QRS complex tachycardia of unknown origin, calcium channel blockers (e.g., verapamil and diltiazem) are potentially harmful . (Level of Evidence: C-LD) "

Ongoing Management of Ventricular Arrhythmia (VA) and Sudden Cardiac Death (SCD) Risk Related to Specific Disease States

Secondary Prevention of SCD in Patients With Ischemic Heart Disease

Recommendations for Secondary Prevention of SCD in Patients With Ischemic Heart Disease

Class I

"1. In patients with ischemic heart disease, who either survive SCA due to VT/VF or experience hemodynamically unstable VT (LOE: B-R) or stable VT (LOE: B- NR) not due to reversible causes, an ICD is recommended if meaningful survival greater than 1 year is expected. (Level of Evidence: B-R / B-NR) "

"2. Value Statement: Intermediate Value (LOE: B-R) A transvenous ICD provides intermediate value in the secondary prevention of SCD particularly when the patient’s risk of death due to a VA is deemed high and the risk of nonarrhythmic death (either cardiac or noncardiac) is deemed low based on the patient’s burden of comorbidities and functional status.

Class I

"3. In patients with ischemic heart disease and unexplained syncope who have inducible sustained monomorphic VT on electrophysiological study, an ICD is recommended if meaningful survival of greater than 1 year is expected. (Level of Evidence: B-NR) "

Coronary Artery Spasm

Recommendations for Patients With Coronary Artery Spasm

Class I

"1. In patients with VA due to coronary artery spasm, treatment with maximally tolerated doses of a calcium channel blocker and smoking cessation are indicated to reduce recurrent ischemia and VA. (Level of Evidence: B-NR) "

Class IIa

"1. In patients resuscitated from SCA due to coronary artery spasm in whom medical therapy is ineffective or not tolerated, an ICD is reasonable if meaningful survival of greater than 1 year is expected. (Level of Evidence: B-NR) "

Class IIb

"1. In patients resuscitated from SCA due to coronary artery spasm, an ICD in addition to medical therapy may be reasonable if meaningful survival of greater than 1 year is expected. (Level of Evidence: B-NR) "

Primary Prevention of SCD in Patients With Ischemic Heart Disease

Recommendations for Primary Prevention of SCD in Patients With Ischemic Heart Disease

Class I

"1. In patients with LVEF of 35% or less that is due to ischemic heart disease who are at least 40 days’ post-MI and at least 90 days postrevascularization, and with NYHA class II or III HF despite GDMT, an ICD is recommended if meaningful survival of greater than 1 year is expected. (Level of Evidence: A) "

"2. In patients with LVEF of 30% or less that is due to ischemic heart disease who are at least 40 days’ post-MI and at least 90 days postrevascularization, and with NYHA class I HF despite GDMT, an ICD is recommended if meaningful survival of greater than 1 year is expected. (Level of Evidence: A) "

"3.Value Statement: High Value (LOE: B-R) A transvenous ICD provides high value in the primary prevention of SCD particularly when the patient’s risk of death due to a VA is deemed high and the risk of nonarrhythmic death (either cardiac or noncardiac) is deemed low based on the patient’s burden of comorbidities and functional status.

Class I

"1. In patients with NSVT due to prior MI, LVEF of 40% or less and inducible sustained VT or VF at electrophysiological study, an ICD is recommended if meaningful survival of greater than 1 year is expected. (Level of Evidence: B-R) "

Class IIa

"1. In nonhospitalized patients with NYHA class IV symptoms who are candidates for cardiac transplantation or an LVAD, an ICD is reasonable if meaningful survival of greater than 1 year is expected. (Level of Evidence: B-NR) "

Class III - No Benefit

"1. An ICD is not indicated for NYHA class IV patients with medication-refractory HF who are not also candidates for cardiac transplantation, an LVAD, or a CRT defibrillator that incorporates both pacing and defibrillation capabilities. (Level of Evidence: C-EO) "

Treatment and Prevention of Recurrent VA in Patients With Ischemic Heart Disease

Recommendations for Treatment of Recurrent VA in Patients With Ischemic Heart Disease

Class I

"1. In patients with ischemic heart disease and recurrent VA, with significant symptoms or ICD shocks despite optimal device programming and ongoing treatment with a beta blocker, amiodarone or sotalol is useful to suppress recurrent VA. (Level of Evidence: B-R) "

"2. In patients with prior MI and recurrent episodes of symptomatic sustained VT, or who present with VT or VF storm and have failed or are intolerant of amiodarone (LOE: B-R) or other antiarrhythmic medications (LOE: B-NR) catheter ablation is recommended . (Level of Evidence: B-R / B-NR) "

Class IIb

"1. In patients with ischemic heart disease and ICD shocks for sustained monomorphic VT or symptomatic sustained monomorphic VT that is recurrent, or hemodynamically tolerated, catheter ablation as first-line therapy may be considered to reduce recurrent VA. (Level of Evidence: C-LD) "

Class III - Harm

"1. In patients with prior MI, class IC antiarrhythmic medications (e.g., flecainide and propafenone) should not be used. (Level of Evidence: B-R) "

"1. In patients with incessant VT or VF, an ICD should not be implanted until sufficient control of the VA is achieved to prevent repeated ICD shocks. (Level of Evidence: C-LD) "

Class III - No benefit

"1. In patients with ischemic heart disease and sustained monomorphic VT, coronary revascularization alone is an ineffective therapy to prevent recurrent VT. (Level of Evidence: C-LD) "