Chronic pancreatitis pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
*Chronic pancreatitis is a progressive inflammatory process leading to irreversible structural damage to pancreas resulting in exocrine and endocrine dysfunction<ref name="pmid7739686">{{cite journal |vauthors=Steer ML, Waxman I, Freedman S |title=Chronic pancreatitis |journal=N. Engl. J. Med. |volume=332 |issue=22 |pages=1482–90 |year=1995 |pmid=7739686 |doi=10.1056/NEJM199506013322206 |url=}}</ref> | *Chronic pancreatitis is a progressive inflammatory process leading to irreversible structural damage to pancreas resulting in exocrine and endocrine dysfunction<ref name="pmid7739686">{{cite journal |vauthors=Steer ML, Waxman I, Freedman S |title=Chronic pancreatitis |journal=N. Engl. J. Med. |volume=332 |issue=22 |pages=1482–90 |year=1995 |pmid=7739686 |doi=10.1056/NEJM199506013322206 |url=}}</ref> | ||
* | *The pathogenesis is still unclear but two findings consistently seen in the pathogenesis of chronic pancreatitis are: | ||
**Protein hypersecretion resulting in proteinaceous ductal plugs leading to ductal blockage and obstruction<ref name="pmid510088">{{cite journal |vauthors=Sahel J, Sarles H |title=Modifications of pure human pancreatic juice induced by chronic alcohol consumption |journal=Dig. Dis. Sci. |volume=24 |issue=12 |pages=897–905 |year=1979 |pmid=510088 |doi= |url=}}</ref> | |||
**Patchy inflammatory lesions in exocrine pancreas seen on microscopic examination | |||
==Genetics== | ==Genetics== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Pathophysiology
- Chronic pancreatitis is a progressive inflammatory process leading to irreversible structural damage to pancreas resulting in exocrine and endocrine dysfunction[1]
- The pathogenesis is still unclear but two findings consistently seen in the pathogenesis of chronic pancreatitis are:
- Protein hypersecretion resulting in proteinaceous ductal plugs leading to ductal blockage and obstruction[2]
- Patchy inflammatory lesions in exocrine pancreas seen on microscopic examination
Genetics
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
- The development of [disease name] is the result of multiple genetic mutations.
Associated Conditions
Gross Pathology
- Patchy focal disease
- Fibrosis
Microscopic Pathology
- On microscopic histopathological analysis:
- Patchy focal disease characterized by a mononuclear infiltrate
- Fibrosis
References
- ↑ Steer ML, Waxman I, Freedman S (1995). "Chronic pancreatitis". N. Engl. J. Med. 332 (22): 1482–90. doi:10.1056/NEJM199506013322206. PMID 7739686.
- ↑ Sahel J, Sarles H (1979). "Modifications of pure human pancreatic juice induced by chronic alcohol consumption". Dig. Dis. Sci. 24 (12): 897–905. PMID 510088.