Whipple's disease medical therapy: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
Line 10: Line 10:


==== Classic Whipple's disease ====
==== Classic Whipple's disease ====
**Initial therapy
*Initial therapy
***Preferred regimen (1): [[Ceftriaxone]] 2 g IV qd for 14 days   
**Preferred regimen (1): [[Ceftriaxone]] 2 g IV qd for 14 days   
***Preferred regimen (2): Penicillin G 2 million units IV q4h for 14 days
**Preferred regimen (2): Penicillin G 2 million units IV q4h for 14 days
***Alternative regimen (1): [[Meropenem]] 1 g IV q8h for 14 days   
**Alternative regimen (1): [[Meropenem]] 1 g IV q8h for 14 days   
**Maintenance therapy
*Maintenance therapy
***Preferred regimen (1):     
**Preferred regimen (1):     
***Alternative regimen (1):   
**Alternative regimen (1):   


==== CNS infection ====
==== CNS infection ====
**Initial therapy
*Initial therapy
**** Preferred regimen (1): [[drug name]] 100 mg PO q12h for 10-21 days '''(Contraindications/specific instructions)'''    
**Preferred regimen (1): [[Ceftriaxone]] 2 g IV qd for 14 days   
**** Preferred regimen (2): [[drug name]] 500 mg PO q8h for 14-21 days
**Preferred regimen (2): Penicillin G 2 million units IV q4h for 14 days
**** Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days   
**Alternative regimen (1): [[Meropenem]] 1 g IV q8h for 14 days   
**Maintenance therapy
*Maintenance therapy
***Preferred regimen (1): [[drug name]] 100 mg PO q12h for 10-21 days '''(Contraindications/specific instructions)''' 
**Preferred regimen (1):  
***Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days  
**Alternative regimen (1):   


==== Endocarditis ====
==== Endocarditis ====
**Initial therapy
*Initial therapy
**** Preferred regimen (1): [[drug name]] 100 mg PO q12h for 10-21 days '''(Contraindications/specific instructions)'''    
**Preferred regimen (1): [[Ceftriaxone]] 2 g IV qd for 14 days   
**** Preferred regimen (2): [[drug name]] 500 mg PO q8h for 14-21 days
**Preferred regimen (2): Penicillin G 2 million units IV q4h for 14 days
**** Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days   
**Alternative regimen (1): [[Meropenem]] 1 g IV q8h for 14 days   
**Maintenance therapy
*Maintenance therapy
***Preferred regimen (1): [[drug name]] 100 mg PO q12h for 10-21 days '''(Contraindications/specific instructions)''' 
**Preferred regimen (1):  
***Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days  
**Alternative regimen (1):   


==== Relapse ====
==== Relapse ====
**Initial therapy
*Initial therapy
**** Preferred regimen (1): [[drug name]] 100 mg PO q12h for 10-21 days '''(Contraindications/specific instructions)'''    
**Preferred regimen (1): [[Ceftriaxone]] 2 g IV qd for 14 days   
**** Preferred regimen (2): [[drug name]] 500 mg PO q8h for 14-21 days
**Preferred regimen (2): Penicillin G 2 million units IV q4h for 14 days
**** Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days   
**Alternative regimen (1): [[Meropenem]] 1 g IV q8h for 14 days   
**Maintenance therapy
*Maintenance therapy
***Preferred regimen (1): [[drug name]] 100 mg PO q12h for 10-21 days '''(Contraindications/specific instructions)''' 
**Preferred regimen (1):  
***Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days  
**Alternative regimen (1):   




Revision as of 21:07, 2 November 2017

Whipple's disease Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Whipple's disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Whipple's disease medical therapy On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Whipple's disease medical therapy

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Whipple's disease medical therapy

CDC on Whipple's disease medical therapy

Whipple's disease medical therapy in the news

Blogs on Whipple's disease medical therapy

Directions to Hospitals Treating Whipple's disease

Risk calculators and risk factors for Whipple's disease medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Overview

The mainstay of treatment for Whipple's disease is systemic long-term antibiotic therapy. Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].

Medical Therapy

  • Pharmacologic medical therapy for Whipple's disease includes long-term antibiotics.

Classic Whipple's disease

  • Initial therapy
    • Preferred regimen (1): Ceftriaxone 2 g IV qd for 14 days
    • Preferred regimen (2): Penicillin G 2 million units IV q4h for 14 days
    • Alternative regimen (1): Meropenem 1 g IV q8h for 14 days
  • Maintenance therapy
    • Preferred regimen (1):
    • Alternative regimen (1):

CNS infection

  • Initial therapy
    • Preferred regimen (1): Ceftriaxone 2 g IV qd for 14 days
    • Preferred regimen (2): Penicillin G 2 million units IV q4h for 14 days
    • Alternative regimen (1): Meropenem 1 g IV q8h for 14 days
  • Maintenance therapy
    • Preferred regimen (1):
    • Alternative regimen (1):

Endocarditis

  • Initial therapy
    • Preferred regimen (1): Ceftriaxone 2 g IV qd for 14 days
    • Preferred regimen (2): Penicillin G 2 million units IV q4h for 14 days
    • Alternative regimen (1): Meropenem 1 g IV q8h for 14 days
  • Maintenance therapy
    • Preferred regimen (1):
    • Alternative regimen (1):

Relapse

  • Initial therapy
    • Preferred regimen (1): Ceftriaxone 2 g IV qd for 14 days
    • Preferred regimen (2): Penicillin G 2 million units IV q4h for 14 days
    • Alternative regimen (1): Meropenem 1 g IV q8h for 14 days
  • Maintenance therapy
    • Preferred regimen (1):
    • Alternative regimen (1):


  • 1. Initial Parenteral Therapy[1]
  • Preferred regimen: Ceftriaxone 2 g IV daily for 2 weeks
  • 2. Long-term Therapy[2]

References

  1. ↑ Bennett, John (2015). Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1455748013.
  2. ↑ Bennett, John (2015). Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1455748013.


Template:WS Template:WH

Retrieved from "https://www.wikidoc.org/index.php?title=Whipple%27s_disease_medical_therapy&oldid=1383379"