Whipple's disease medical therapy: Difference between revisions
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**Alternative regimen (1): [[Meropenem]] 1 g IV q8h for 14 days | **Alternative regimen (1): [[Meropenem]] 1 g IV q8h for 14 days | ||
*Maintenance therapy | *Maintenance therapy | ||
**Preferred regimen (1): Trimethoprim-sulfamethoxazole one DS tablet PO q12h | **Preferred regimen (1): [[Sulfamethoxazole-Trimethoprim|Trimethoprim-sulfamethoxazole]] one DS tablet PO q12h | ||
**Alternative regimen (1): Doxycycline 100 mg PO q12h AND Hydroxychloroquine 200 mg PO q8h | **Alternative regimen (1): [[Doxycycline]] 100 mg PO q12h <u>'''AND'''</u> [[Hydroxychloroquine]] 200 mg PO q8h | ||
==== CNS infection ==== | ==== CNS infection ==== | ||
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**Alternative regimen (1): [[Meropenem]] 1 g IV q8h for 14 days | **Alternative regimen (1): [[Meropenem]] 1 g IV q8h for 14 days | ||
*Maintenance therapy | *Maintenance therapy | ||
**Preferred regimen (1): | **Preferred regimen (1): [[Sulfamethoxazole-Trimethoprim|Trimethoprim-sulfamethoxazole]] one DS tablet PO q12h | ||
**Alternative regimen (1): | **Alternative regimen (1): [[Doxycycline]] 100 mg PO q12h '''<u>AND</u>''' [[Hydroxychloroquine]] 200 mg PO q8h | ||
==== Endocarditis ==== | ==== Endocarditis ==== | ||
Line 33: | Line 33: | ||
**Alternative regimen (1): [[Meropenem]] 1 g IV q8h for 14 days | **Alternative regimen (1): [[Meropenem]] 1 g IV q8h for 14 days | ||
*Maintenance therapy | *Maintenance therapy | ||
**Preferred regimen (1): | **Preferred regimen (1): [[Sulfamethoxazole-Trimethoprim|Trimethoprim-sulfamethoxazole]] one DS tablet PO q12h | ||
**Alternative regimen (1): | **Alternative regimen (1): [[Doxycycline]] 100 mg PO q12h '''<u>AND</u>''' [[Hydroxychloroquine]] 200 mg PO q8h | ||
==== Relapse ==== | ==== Relapse ==== |
Revision as of 21:11, 2 November 2017
Whipple's disease Microchapters |
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Treatment |
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Whipple's disease medical therapy On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
The mainstay of treatment for Whipple's disease is systemic long-term antibiotic therapy. Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].
Medical Therapy
- Pharmacologic medical therapy for Whipple's disease includes long-term antibiotics.
Classic Whipple's disease
- Initial therapy
- Preferred regimen (1): Ceftriaxone 2 g IV qd for 14 days
- Preferred regimen (2): Penicillin G 2 million units IV q4h for 14 days
- Alternative regimen (1): Meropenem 1 g IV q8h for 14 days
- Maintenance therapy
- Preferred regimen (1): Trimethoprim-sulfamethoxazole one DS tablet PO q12h
- Alternative regimen (1): Doxycycline 100 mg PO q12h AND Hydroxychloroquine 200 mg PO q8h
CNS infection
- Initial therapy
- Preferred regimen (1): Ceftriaxone 2 g IV qd for 14 days
- Preferred regimen (2): Penicillin G 2 million units IV q4h for 14 days
- Alternative regimen (1): Meropenem 1 g IV q8h for 14 days
- Maintenance therapy
- Preferred regimen (1): Trimethoprim-sulfamethoxazole one DS tablet PO q12h
- Alternative regimen (1): Doxycycline 100 mg PO q12h AND Hydroxychloroquine 200 mg PO q8h
Endocarditis
- Initial therapy
- Preferred regimen (1): Ceftriaxone 2 g IV qd for 14 days
- Preferred regimen (2): Penicillin G 2 million units IV q4h for 14 days
- Alternative regimen (1): Meropenem 1 g IV q8h for 14 days
- Maintenance therapy
- Preferred regimen (1): Trimethoprim-sulfamethoxazole one DS tablet PO q12h
- Alternative regimen (1): Doxycycline 100 mg PO q12h AND Hydroxychloroquine 200 mg PO q8h
Relapse
- Initial therapy
- Preferred regimen (1): Ceftriaxone 2 g IV qd for 14 days
- Preferred regimen (2): Penicillin G 2 million units IV q4h for 14 days
- Alternative regimen (1): Meropenem 1 g IV q8h for 14 days
- Maintenance therapy
- Preferred regimen (1):
- Alternative regimen (1):