Plummer-Vinson syndrome causes: Difference between revisions
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==Overview== | ==Overview== | ||
The cause of Plummer-Vinson syndrome is unknown; however, iron deficiency anemia, [[Genetics|genetic]] factors and [[nutrition|nutritional deficiencies]] may play a role. Iron deficiency anemia is the most widely regarded cause of Plummer-Vinson syndrome and can be due to increased iron demands, | The cause of Plummer-Vinson syndrome is unknown; however, iron deficiency anemia, [[Genetics|genetic]] factors and [[nutrition|nutritional deficiencies]] may play a role. Iron deficiency anemia is the most widely regarded cause of Plummer-Vinson syndrome and can be due to increased iron demands, decreased intake and malabsorption syndromes. | ||
==Causes== | ==Causes== | ||
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**Nosocomial blood loss: phlebotomy for diagnostic tests in hospitalized patients | **Nosocomial blood loss: phlebotomy for diagnostic tests in hospitalized patients | ||
**Following gastric or small bowel surgery: due to loss of gastric acidity, increased transit time for food, and decreased absorption of iron | **Following gastric or small bowel surgery: due to loss of gastric acidity, increased transit time for food, and decreased absorption of iron | ||
*Conditions leading to impaired iron absorption | *Conditions leading to impaired iron absorption | ||
**[[Celiac disease]] | **[[Celiac disease]] | ||
**Tropical sprue | **Tropical sprue | ||
**[[Gastric surgery]] | **[[Gastric surgery]] | ||
** [[ | **[[Hypochlorhydria]] | ||
**Taking too many antacids that contain [[calcium]] | **Taking too many antacids that contain [[calcium]] | ||
**Whipple disease | **Whipple disease | ||
**Kwashiorkor disease | **Kwashiorkor disease | ||
**Alcoholism | **Alcoholism | ||
===Less common causes=== | ===Less common causes=== | ||
Revision as of 15:12, 3 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]
Overview
The cause of Plummer-Vinson syndrome is unknown; however, iron deficiency anemia, genetic factors and nutritional deficiencies may play a role. Iron deficiency anemia is the most widely regarded cause of Plummer-Vinson syndrome and can be due to increased iron demands, decreased intake and malabsorption syndromes.
Causes
The cause of Plummer-Vinson syndrome is unknown; however, iron deficiency anemia, genetic factors and nutritional deficiencies may play a role. Iron deficiency anemia is the most widely regarded cause of Plummer-Vinson syndrome and can be due to:
Common causes
Common causes of iron deficiency anemia associated with Plummer-Vinson syndrome are:
- Physiological conditions with increased iron requirements are seen with:
- Conditions promoting blood loss leads to an increased demand of iron by the body. These include:
- Menstruation
- Gastrointestinal tract disorders such as:
- Bleeding from the gastrointestinal tract (peptic ulcers
- Hemorrhoids
- Esophageal varices
- NSAIDs (aspirin,ibuprofen
- Cancer in the esophagus, stomach, or colon
- Hookworms
- Genitourinary tract disorders such as:
- Glomerulonephritis
- Renal calculi
- Hemoptysis (alveolar hemorrhage)
- Nosocomial blood loss: phlebotomy for diagnostic tests in hospitalized patients
- Following gastric or small bowel surgery: due to loss of gastric acidity, increased transit time for food, and decreased absorption of iron
- Conditions leading to impaired iron absorption
- Celiac disease
- Tropical sprue
- Gastric surgery
- Hypochlorhydria
- Taking too many antacids that contain calcium
- Whipple disease
- Kwashiorkor disease
- Alcoholism
Less common causes
- Hereditary hemorrhagic telangiectasia: recurrent hemorrhage
- Intravascular hemolysis: for example, paroxysmal nocturnal hemoglobinuria
- Iatrogenic causes such as frequent blood draws, particularly in hospitalized patients
- Inadequate diet in children (excessive consumption of whole cow's milk)