Chronic pancreatitis pathophysiology: Difference between revisions
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==Associated Conditions== | ==Associated Conditions== | ||
* Autoimmune conditions | |||
** Primary biliary cirrhosis | |||
** Primary sclerosing cholangitis | |||
** Sjögren syndrome | |||
** Renal tubular acidosis | |||
==Gross Pathology== | ==Gross Pathology== | ||
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**Patchy focal disease characterized by a mononuclear infiltrate | **Patchy focal disease characterized by a mononuclear infiltrate | ||
**Fibrosis | **Fibrosis | ||
**Necrosis | |||
==References== | ==References== | ||
Revision as of 16:28, 3 November 2017
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Chronic pancreatitis Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Pathophysiology
- Chronic pancreatitis is a progressive inflammatory process leading to irreversible structural damage to pancreas resulting in exocrine and endocrine dysfunction[1]
- The pathogenesis is still unclear but two findings consistently seen in the pathogenesis of chronic pancreatitis are:
- Protein hypersecretion resulting in proteinaceous ductal plugs leading to ductal blockage and obstruction[2]
- Patchy inflammatory lesions in exocrine pancreas seen on microscopic examination
Following factors are thought to play an important role in the pathogenesis of chronic pancreatitis:
(a) Intraductal plugging and obstruction
(b) Direct injury to pancreatic cells induced by toxins and toxic metabolites
(c) Antioxidants
(d) Ischemia
(e) Autoimmune disorders
(f) Necrosis and fibrosis
Genetics
Genes involved in the pathogenesis of chronic pancreatitis include:
- Cystic fibrosis gene mutation
- Pancreatitis susceptibility genes
Associated Conditions
- Autoimmune conditions
- Primary biliary cirrhosis
- Primary sclerosing cholangitis
- Sjögren syndrome
- Renal tubular acidosis
Gross Pathology
- Patchy focal disease
- Fibrosis
Microscopic Pathology
- On microscopic histopathological analysis:
- Patchy focal disease characterized by a mononuclear infiltrate
- Fibrosis
- Necrosis
References
- ↑ Steer ML, Waxman I, Freedman S (1995). "Chronic pancreatitis". N. Engl. J. Med. 332 (22): 1482–90. doi:10.1056/NEJM199506013322206. PMID 7739686.
- ↑ Sahel J, Sarles H (1979). "Modifications of pure human pancreatic juice induced by chronic alcohol consumption". Dig. Dis. Sci. 24 (12): 897–905. PMID 510088.