Whipple's disease other diagnostic studies: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Whipple's disease}} | {{Whipple's disease}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{BHA}} | ||
==Overview== | ==Overview== | ||
Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Findings diagnostic of [ Whipple's disease] include PAS positive inclusions in macrophages of lamina propria. | Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Findings diagnostic of [[ Whipple's disease]] include PAS positive inclusions in macrophages of lamina propria. | ||
Other diagnostic studies for [Whipple's disease] include electron microscopy which | Other diagnostic studies for [[Whipple's disease]] include [[electron microscopy]] which demonstrate bacteria , [[immunofluoroscent assay]] to detect antibodies against T whippleii and [[PCR]], which demonstrates 16S rRNA gene of T. Whipplei. | ||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
*Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Findings diagnostic of [ Whipple's disease] include: | *Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Findings diagnostic of [[ Whipple's disease]] include:<ref name="DutlyAltwegg2001">{{cite journal|last1=Dutly|first1=F.|last2=Altwegg|first2=M.|title=Whipple's Disease and "Tropheryma whippelii"|journal=Clinical Microbiology Reviews|volume=14|issue=3|year=2001|pages=561–583|issn=0893-8512|doi=10.1128/CMR.14.3.561-583.2001}}</ref> | ||
**PAS positive inclusions in macrophages of lamina propria. | **PAS positive inclusions in macrophages of lamina propria. | ||
**All the organs affected by disease may demostrate PAS-positive macrophages like heart, lungs, CNS , eyes, liver, spleen, joints, and bone marrow. | **All the organs affected by disease may demostrate PAS-positive macrophages like heart, lungs, CNS , eyes, liver, spleen, joints, and bone marrow. | ||
*Other diagnostic studies for [Whipple's disease] which confirm the diagnosis include: | *Other diagnostic studies for [[Whipple's disease]] which confirm the diagnosis include: | ||
**[Electron Microscopy], which demonstrates: | **[[Electron Microscopy]], which demonstrates:<ref name="DutlyAltwegg2001">{{cite journal|last1=Dutly|first1=F.|last2=Altwegg|first2=M.|title=Whipple's Disease and "Tropheryma whippelii"|journal=Clinical Microbiology Reviews|volume=14|issue=3|year=2001|pages=561–583|issn=0893-8512|doi=10.1128/CMR.14.3.561-583.2001}}</ref> | ||
***typical trilamellar membrane of T. Whippleii. | ***typical trilamellar membrane of T. Whippleii. | ||
***gram positive cell wall structure | ***gram positive cell wall structure | ||
* PCR of affected tissue which demonstrates: | * [[PCR]] of affected tissue which demonstrates:<ref name="DutlyAltwegg2001">{{cite journal|last1=Dutly|first1=F.|last2=Altwegg|first2=M.|title=Whipple's Disease and "Tropheryma whippelii"|journal=Clinical Microbiology Reviews|volume=14|issue=3|year=2001|pages=561–583|issn=0893-8512|doi=10.1128/CMR.14.3.561-583.2001}}</ref> | ||
**16S rRNA gene of T. Whipplei | **16S rRNA gene of T. Whipplei | ||
* Immunofluoroscent assay of serum of patients with Whipple's disease which demonstrates: | * [[Immunofluoroscent assay]] of serum of patients with Whipple's disease which demonstrates:<ref name="DutlyAltwegg2001">{{cite journal|last1=Dutly|first1=F.|last2=Altwegg|first2=M.|title=Whipple's Disease and "Tropheryma whippelii"|journal=Clinical Microbiology Reviews|volume=14|issue=3|year=2001|pages=561–583|issn=0893-8512|doi=10.1128/CMR.14.3.561-583.2001}}</ref> | ||
**Antibodies against T. Whippleii in patients' serum. | **Antibodies against T. Whippleii in patients' serum. | ||
Revision as of 11:49, 6 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Bhagyashree Deshmankar M.B.B.S.[2]
Overview
Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Findings diagnostic of Whipple's disease include PAS positive inclusions in macrophages of lamina propria.
Other diagnostic studies for Whipple's disease include electron microscopy which demonstrate bacteria , immunofluoroscent assay to detect antibodies against T whippleii and PCR, which demonstrates 16S rRNA gene of T. Whipplei.
Other Diagnostic Studies
- Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Findings diagnostic of Whipple's disease include:[1]
- PAS positive inclusions in macrophages of lamina propria.
- All the organs affected by disease may demostrate PAS-positive macrophages like heart, lungs, CNS , eyes, liver, spleen, joints, and bone marrow.
- Other diagnostic studies for Whipple's disease which confirm the diagnosis include:
- Electron Microscopy, which demonstrates:[1]
- typical trilamellar membrane of T. Whippleii.
- gram positive cell wall structure
- 16S rRNA gene of T. Whipplei
- Immunofluoroscent assay of serum of patients with Whipple's disease which demonstrates:[1]
- Antibodies against T. Whippleii in patients' serum.