Whipple's disease classification: Difference between revisions

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{{Whipple's disease}}
 
{{CMG}}; {{AE}} {{SSH}}
{{CMG}}; {{AE}} {{SSH}}


==Overview==
==Overview==
Whipple’s disease may be classified into 4 groups based on clinical manifestation: Acute infection, asymptomatic carrier state, the classic Whipple’s disease, and localized chronic infection.  
Whipple’s disease may be classified into 2 groups of [[acute]] and [[chronic]] [[infection]]. It might be classified as [[systemic]] or localized based on the [[Organ (biology)|organ]] involvement. It has 4 different [[clinical]] manifestations: [[Acute]] [[infection]], [[asymptomatic carrier]] state, the classic Whipple’s disease, and localized [[chronic]] [[infection]].  


==Classification==
==Classification==

Revision as of 15:44, 10 November 2017


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Overview

Whipple’s disease may be classified into 2 groups of acute and chronic infection. It might be classified as systemic or localized based on the organ involvement. It has 4 different clinical manifestations: Acute infection, asymptomatic carrier state, the classic Whipple’s disease, and localized chronic infection.

Classification


Whipple's disease classification based on the duration

 
 
 
 
 
 
 
 
 
 
 
 
 
Whipple's disease classification
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Acute
 
 
 
 
 
 
 
Chronic
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Gastroenteritis
 
Pneumonia
 
Bacteremia
 
Asymptomatic carrier state
 
 
Classic Whipple's disease
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Chronic localized infection
 
 
 
 
 
 



Whipple's disease classification based on organ involvement


 
 
 
 
 
 
 
 
Whipple's disease classification
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Systemic involvement
 
 
 
 
 
 
 
 
 
 
 
 
 
Localized involvement
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Heart
 
CNS
 
Eye
 
Lung
 
Bone
 
Serosa
 
Skin
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
• Blood-culture negative endocarditis
• Adhesive pericarditis
Myocardial fibrosis
 
Encephalitis
• Progressive dementia
Cerebellar ataxia
• Personality changes
Hemiparesis
Seizure
Wernicke’s encephalopathy
Hypothalamic involvement
Supranuclear ophthalmoplegia
 
Uveitis
Vitritis
Retinitis
Retrobulbar neuritis
Papilledema
 
• Chronic cough
Dyspnea
 
Arthritis
Spondylodiscitis
 
Pleuritic chest pain
 
Hyperpigmentation
 
 



References

  1. Marth, Thomas (2009). "New Insights into Whipple's Disease – A Rare Intestinal Inflammatory Disorder". Digestive Diseases. 27 (4): 494–501. doi:10.1159/000233288. ISSN 1421-9875.
  2. Street, Sara; Donoghue, Helen D; Neild, GH (1999). "Tropheryma whippelii DNA in saliva of healthy people". The Lancet. 354 (9185): 1178–1179. doi:10.1016/S0140-6736(99)03065-2. ISSN 0140-6736.

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