Peptic ulcer historical perspective: Difference between revisions
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*In 1913, Rosenow found that streptococci produce ulcers | *In 1913, Rosenow found that streptococci produce ulcers | ||
*Spiral-shaped microorganism described by Polish clinical researcher Professor W.Jaworski at Cracow Jagiellonian University 100 years ago but it was confirmed in the animal by G.Bizzazero.In late 1970, J.R Warren, a pathologist in Perth, Australia found the appearance of spiral bacteria overlying gastric mucosa.<ref name="pmid15075463">{{cite journal |vauthors=Konturek JW |title=Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer |journal=J. Physiol. Pharmacol. |volume=54 Suppl 3 |issue= |pages=23–41 |year=2003 |pmid=15075463 |doi= |url=}}</ref> | *Spiral-shaped microorganism described by Polish clinical researcher Professor W.Jaworski at Cracow Jagiellonian University 100 years ago but it was confirmed in the animal by G.Bizzazero.In late 1970, J.R Warren, a pathologist in Perth, Australia found the appearance of spiral bacteria overlying gastric mucosa.<ref name="pmid15075463">{{cite journal |vauthors=Konturek JW |title=Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer |journal=J. Physiol. Pharmacol. |volume=54 Suppl 3 |issue= |pages=23–41 |year=2003 |pmid=15075463 |doi= |url=}}</ref> | ||
*In 1915, Antacids are first recommended for the treatment of PUD and bacteria are associated with PUD, but it is assumed that the bacteria reside in the mouth.[9] | |||
1919 | |||
Katsuya Kasai and Rokuzo Kobayashi isolate spirochetes in cats and transmit them to rabbits, producing ulcers.[10] | |||
1921 | |||
Luger discovers spirochetes in the gastric juice, and associates their presence with gastric cancer.[4] | |||
Urease | |||
1924 | |||
Luck and Seth discover urease in the human stomach, which they believe is naturally occurring.[11] | |||
1925 | |||
Hoffman injects a small sample from a human with PUD into a guinea pig, producing ulcers, and isolates a bacterium which he believes caused the ulcers.[12] | |||
1936 | |||
First edition of the Russian Large Medical Encyclopedia suggests infection is one of the causes of PUD.[13] | |||
1939 | |||
A. Stone Freedberg begins a study to look for bacteria in the human stomach at Beth Israel Hospital. He finds H. pylori. It is rumored that others cannot reproduce the results, although no negative results are published.[14] | |||
James Doenges describes spirochetes in autopsies.[15] | |||
1940 | |||
Freedberg and Baron observe spirochetes in autopsies.[16] Freedberg abandons his research, however, after his boss advises him to move to another subject. In 2005, Marshall speculates that Freedberg would have won the Nobel Prize in 1951 had he continued his work.[17] | |||
1948 | |||
Fitzgerald and Murphy hypothesize that PUD is caused by acid eating away mucosa, and demonstrate the effectiveness of urea as a treatment for PUD | |||
*The association between Helicobacter pylori and peptic ulcer disease was made in 1982 by Warren and B.J marshall.They contended that most stomach ulcers and gastritis were caused by colonization with this bacterium, not by [[stress (medicine)|stress]] or [[spicy food]] as had been assumed before.<ref>{{cite journal|author=Marshall BJ, Warren JR|title=Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration|journal=Lancet|year=1984|volume=1|issue=8390|pages=1311–1315|id=PMID 6145023}}</ref><ref name="pmid15075463">{{cite journal |vauthors=Konturek JW |title=Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer |journal=J. Physiol. Pharmacol. |volume=54 Suppl 3 |issue= |pages=23–41 |year=2003 |pmid=15075463 |doi= |url=}}</ref><ref name="urlHome | CDC Ulcer">{{cite web |url=https://www.cdc.gov/ulcer/index.htm |title=Home | CDC Ulcer |format= |work= |accessdate=}}</ref> | *The association between Helicobacter pylori and peptic ulcer disease was made in 1982 by Warren and B.J marshall.They contended that most stomach ulcers and gastritis were caused by colonization with this bacterium, not by [[stress (medicine)|stress]] or [[spicy food]] as had been assumed before.<ref>{{cite journal|author=Marshall BJ, Warren JR|title=Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration|journal=Lancet|year=1984|volume=1|issue=8390|pages=1311–1315|id=PMID 6145023}}</ref><ref name="pmid15075463">{{cite journal |vauthors=Konturek JW |title=Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer |journal=J. Physiol. Pharmacol. |volume=54 Suppl 3 |issue= |pages=23–41 |year=2003 |pmid=15075463 |doi= |url=}}</ref><ref name="urlHome | CDC Ulcer">{{cite web |url=https://www.cdc.gov/ulcer/index.htm |title=Home | CDC Ulcer |format= |work= |accessdate=}}</ref> | ||
A National Institutes of Health Consensus Development Conference 1994 concludes that there is a strong association between H. pylori and ulcer disease, and recommends that ulcer | A National Institutes of Health Consensus Development Conference 1994 concludes that there is a strong association between H. pylori and ulcer disease, and recommends that ulcer | ||
Revision as of 18:42, 13 November 2017
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Peptic ulcer Microchapters |
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Diagnosis |
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Treatment |
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Surgery |
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Case Studies |
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2017 ACG Guidelines for Peptic Ulcer Disease |
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Guidelines for the Indications to Test for, and to Treat, H. pylori Infection |
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Guidlines for factors that predict the successful eradication when treating H. pylori infection |
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Guidelines to document H. pylori antimicrobial resistance in the North America |
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Guidelines for evaluation and testing of H. pylori antibiotic resistance |
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Guidelines for when to test for treatment success after H. pylori eradication therapy |
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Guidelines for penicillin allergy in patients with H. pylori infection |
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Peptic ulcer historical perspective On the Web |
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American Roentgen Ray Society Images of Peptic ulcer historical perspective |
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Risk calculators and risk factors for Peptic ulcer historical perspective |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ;Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Historical Perspective
In 1997, the Centers for Disease Control and Prevention, with other government agencies, academic institutions, and industry, launched a national education campaign to inform health care providers and consumers about the link between H. pylori and ulcers. This campaign reinforced the news that ulcers are a curable infection, and the fact that health can be greatly improved and money saved by disseminating information about H. pylori.[1]
Helicobacter pylori was rediscovered in 1982 by two Australian scientists Robin Warren and Barry Marshall[2]. In their original paper, Warren and Marshall contended that most stomach ulcers and gastritis were caused by colonization with this bacterium, not by stress or spicy food as had been assumed before.[3]
The H. pylori hypothesis was poorly received, so in an act of self-experimentation Marshall drank a petri-dish containing a culture of organisms extracted from a patient and soon developed gastritis. His symptoms disappeared after two weeks, but he took antibiotics to kill the remaining bacteria at the urging of his wife, since halitosis is one of the symptoms of infection.[4] This experiment was published in 1984 in the Australian Medical Journal and is among the most cited articles from the journal.
In 2005, the Karolinska Institute in Stockholm awarded the Nobel Prize in Physiology or Medicine to Dr. Marshall and his long-time collaborator Dr. Warren "for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease". Professor Marshall continues research related to H. pylori and runs a molecular biology lab at UWA in Perth, Western Australia.
- Gastric ulcer was first discovered by Goldstein, a [nationality + occupation], in [year]/during/following [event].
- Spiral-shaped microorganism described by Polish clinical researcher Professor W.Jaworski at Cracow Jagiellonian University 100 years ago but it was confirmed in the animal by G.Bizzazero.In late 1970, J.R Warren, a pathologist in Perth, Australia found the appearance of spiral bacteria overlying gastric mucosa.
In 1982 Warren and B.J marshall cultured the organism and demonstrate a strong association between Helicobacter pylori and inflammation of gastric mucosa ,it is not due to spicy food and stress [5][6] 1994 A National Institutes of Health Consensus Development Conference concludes that there is a strong association between H. pylori and ulcer disease, and recommends that ulcer patients with H. pylori infection be treated with antibiotics.
Overview
Historical Perspective
Discovery
- In 16th, 17th century, 18th and 19th centuries,Smith , Rivers and Goldstein wrote chapters on the peptic ulcer disease[7]
- In pre 16th century
- Hippocrates first describes symptoms of peptic ulcer
- Avicenna described the relationship between gastric pain and mealtimes in peptic ulcer patient [8]
- In 1586, Marcellus Donatus of Mantua described gastric ulcers by performing autopsies
- In 1688, duodenal ulcers observed by Johannes von Murault
- In 1812, Broussais found that if acute gastritis is untreated, it can lead to chronic gastritis
- In 1821, Nepveu found a relationship between gastritis and gastric cancer
- In 1857, William Brintonin in his book on ulcer of the stomach described ulcer disease and gastric cancer
- In 1868, Kussmaul discovered that an antibacterial agent containing bismuth used to treat peptic ulcers
- In 1875, G. Bottcher and M. Letulle hypothesize that ulcers are caused by bacteria
- In 1880, J. Cohnheim found that ulcers may be caused by chemical factors
- In 1889, Walery Jaworski found spiral organisms in sediment washings of humans and described organisms may be involved with gastric disease
- In 1910 ,Moynihan wrote a book on duodenal ulcer[9]
- In 1913, Rosenow found that streptococci produce ulcers
- Spiral-shaped microorganism described by Polish clinical researcher Professor W.Jaworski at Cracow Jagiellonian University 100 years ago but it was confirmed in the animal by G.Bizzazero.In late 1970, J.R Warren, a pathologist in Perth, Australia found the appearance of spiral bacteria overlying gastric mucosa.[5]
- In 1915, Antacids are first recommended for the treatment of PUD and bacteria are associated with PUD, but it is assumed that the bacteria reside in the mouth.[9]
1919 Katsuya Kasai and Rokuzo Kobayashi isolate spirochetes in cats and transmit them to rabbits, producing ulcers.[10] 1921 Luger discovers spirochetes in the gastric juice, and associates their presence with gastric cancer.[4]
Urease 1924 Luck and Seth discover urease in the human stomach, which they believe is naturally occurring.[11] 1925 Hoffman injects a small sample from a human with PUD into a guinea pig, producing ulcers, and isolates a bacterium which he believes caused the ulcers.[12] 1936 First edition of the Russian Large Medical Encyclopedia suggests infection is one of the causes of PUD.[13] 1939 A. Stone Freedberg begins a study to look for bacteria in the human stomach at Beth Israel Hospital. He finds H. pylori. It is rumored that others cannot reproduce the results, although no negative results are published.[14] James Doenges describes spirochetes in autopsies.[15] 1940 Freedberg and Baron observe spirochetes in autopsies.[16] Freedberg abandons his research, however, after his boss advises him to move to another subject. In 2005, Marshall speculates that Freedberg would have won the Nobel Prize in 1951 had he continued his work.[17] 1948 Fitzgerald and Murphy hypothesize that PUD is caused by acid eating away mucosa, and demonstrate the effectiveness of urea as a treatment for PUD
- The association between Helicobacter pylori and peptic ulcer disease was made in 1982 by Warren and B.J marshall.They contended that most stomach ulcers and gastritis were caused by colonization with this bacterium, not by stress or spicy food as had been assumed before.[10][5][6]
A National Institutes of Health Consensus Development Conference 1994 concludes that there is a strong association between H. pylori and ulcer disease, and recommends that ulcer
In 2005, the Karolinska Institute in Stockholm awarded the Nobel Prize in Physiology or Medicine to Dr. Marshall and his long-time collaborator Dr. Warren "for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease". Professor Marshall continues research related to H. pylori and runs a molecular biology lab at UWA in Perth, Western Australiaer patients with H. pylori infection be treated with antibiotics.
- In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
Outbreaks
- There have been several outbreaks of [disease name], which are summarized below:
Landmark Events in the Development of Treatment Strategies
- In 1996 first antibiotic was developed by the Food and Drug Administration to treat peptic ulcer disease.[11]
Impact on Cultural History
Famous Cases
- The following are a few famous cases of disease name:
References
- ↑ Ulcer, Diagnosis and Treatment - CDC Bacterial, Mycotic Diseases
- ↑ Marshall BJ (1983). "Unidentified curved bacillus on gastric epithelium in active chronic gastritis". Lancet. 1 (8336): 1273–1275. PMID 6134060.
- ↑ Marshall BJ, Warren JR (1984). "Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration". Lancet. 1 (8390): 1311–1315. PMID 6145023.
- ↑ "Research Enterprise, The 2005 Nobel Prize in Physiology or Medicine". Retrieved 2007-08-26.
- ↑ 5.0 5.1 5.2 Konturek JW (2003). "Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer". J. Physiol. Pharmacol. 54 Suppl 3: 23–41. PMID 15075463.
- ↑ 6.0 6.1 "Home | CDC Ulcer".
- ↑ Graham DY (2014). "History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer". World J. Gastroenterol. 20 (18): 5191–204. doi:10.3748/wjg.v20.i18.5191. PMC 4017034. PMID 24833849.
- ↑ Kidd M, Modlin IM (1998). "A century of Helicobacter pylori: paradigms lost-paradigms regained". Digestion. 59 (1): 1–15. PMID 9468093.
- ↑ Barry, J (2002). Helicobacter pioneers : firsthand accounts from the scientists who discovered helicobacters, 1892-1982. Victoria, Australia Malden, MA, USA: Blackwell. ISBN 0867930357.
- ↑ Marshall BJ, Warren JR (1984). "Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration". Lancet. 1 (8390): 1311–1315. PMID 6145023.
- ↑ Ulcer, Diagnosis and Treatment - CDC Bacterial, Mycotic Diseases