Pancreatic cancer differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Pancreatic cancer must be differentiated from choledocholithiasis, pancreatic pseudocyst, cystic neoplasm and carcinoma of the biliary tract

Differentiating Pancreatic Cancer from other Diseases

The following diseases have a similar presentation as pancreatic cancer:

ORIGIN	DISEASES	DIFFERENTIATION BASED ON INVESTIGATIONS
Pancreas	Chronic pancreatitis Autoimmune pancreatitis Pseudocyst of pancreas Neuroendocrine tumors of pancreas Gastrinoma VIPoma Somatostatinoma	Imaging: Non contrast helical CT Biopsy findings
Bile duct	Choledocholithiasis Cholangiocarcinoma Bile duct strictures	Imaging: MRI MRCP Biopsy findings
Duodenum	Ampullary cancer Duodenal cancer	Imaging: MRI ERCP Biopsy findings
Lymphovascular tissue	Abdominal aortic aneurysm Intestinal ischemia Lymphomas gastric pancreatic	Imaging: MRI MR Angiography CT Angiography Biopsy for lymphoma
Metastasis	skin(Melanoma) kidney breast colon liver(Hepatocellular carcinoma) stomach	Imaging: MRI PET scan CT Biopsy Specific markers for different cancers: HCC: AFP Breast: BRCA 1 and 2 Colon cancer: CEA Melanoma: S100