Pancreatic cancer history and symptoms: Difference between revisions

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{{CMG}}; {{AE}} {{ARK}}
{{CMG}}; {{AE}} {{ARK}}
==Overview==
==Overview==
A positive history of cigarette Smoking, alcoholism, diabetes mellitus, chronic pancreatitis and family history of pancreatic cancer are considered as risk factors for developing Pancreatic cancer. The most common symptoms of Pancreatic cancer include mid-epigastric pain, jaundice, sudden unexplained weight Loss and dark urine and light-colored or greasy stools are suggestive of Pancreatic cancer.
A positive history of cigarette [[smoking]], [[alcoholism]], [[diabetes mellitus]], chronic pancreatitis and family history of pancreatic cancer are considered as risk factors for developing Pancreatic cancer. The most common symptoms of Pancreatic cancer include mid-[[epigastric pain]], [[jaundice]], sudden unexplained [[weight loss]] and [[dark urine]] and light-colored or greasy stools are suggestive of Pancreatic cancer.


==History and Symptoms==
==History and Symptoms==
*A positive history of cigarette Smoking, alcoholism, diabetes mellitus, chronic pancreatitis and family history of pancreatic cancer are considered as risk factors for developing Pancreatic cancer. The most common symptoms of Pancreatic cancer include mid-epigastric pain, jaundice, sudden unexplained weight Loss and dark urine and light-colored or greasy stools are suggestive of Pancreatic cancer.
*A positive history of cigarette [[smoking]], [[alcoholism]], [[diabetes mellitus]], chronic pancreatitis and family history of pancreatic cancer are considered as risk factors for developing Pancreatic cancer. The most common symptoms of Pancreatic cancer include mid-[[epigastric pain]], [[jaundice]], sudden unexplained [[weight loss]] and [[dark urine]] and light-colored or greasy stools are suggestive of Pancreatic cancer.r.
===History===
===History===
*Patients with Pancreatic cancer may have a positive history of:
*Patients with Pancreatic cancer may have a positive history of:
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*Steatorrhea
*Steatorrhea
*Diarrhoea
*Diarrhoea
<br/>
<br />
*'''Functional Pancreatic Neuroendocrine Tumors and their Characteristics are mentioned in the following table:'''<ref name="pmid25207767">{{cite journal| author=Ryan DP, Hong TS, Bardeesy N| title=Pancreatic adenocarcinoma. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 11 | pages= 1039-49 | pmid=25207767 | doi=10.1056/NEJMra1404198 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25207767  }} </ref>
*'''Functional Pancreatic Neuroendocrine Tumors and their Characteristics are mentioned in the following table:'''<ref name="pmid25207767">{{cite journal| author=Ryan DP, Hong TS, Bardeesy N| title=Pancreatic adenocarcinoma. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 11 | pages= 1039-49 | pmid=25207767 | doi=10.1056/NEJMra1404198 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25207767  }} </ref>


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! colspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Functional Pancreatic Neuroendocrine Tumors and their Characteristics'''
! colspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Functional Pancreatic Neuroendocrine Tumors and their Characteristics'''
|+  
|+  
| rowspan="1" colspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Tumor type and syndrome'''
| colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Tumor type and syndrome'''
| rowspan="1" colspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Location in pancreas'''
| colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Location in pancreas'''
| rowspan="1" colspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Signs and symptoms'''
| colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Signs and symptoms'''
| rowspan="1" colspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Circulating biomarkers'''
| colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" + | '''Circulating biomarkers'''
|-
|-
| style="background:#DCDCDC; + | '''Insulinoma (Whipple’s triad)'''
| style="background:#DCDCDC; + " | '''Insulinoma (Whipple’s triad)'''
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*Head, body, tail (evenly distributed)
*Head, body, tail (evenly distributed)
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*Hypoglycemia, dizziness, sweating, tachycardia, tremulousness, confusion, seizure
*Hypoglycemia, dizziness, sweating, tachycardia, tremulousness, confusion, seizure
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*CgA and CgB, insulin inappropriate for blood glucose level, proinsulin, C-peptide
*CgA and CgB, insulin inappropriate for blood glucose level, proinsulin, C-peptide
|-
|-
| style="background:#DCDCDC; + | '''Gastrinoma (Zollinger–Ellison)'''
| style="background:#DCDCDC; + " | '''Gastrinoma (Zollinger–Ellison)'''
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*Gastrinoma triangle Often extrapancreatic (duodenal); can be found anywhere in gland
*Gastrinoma triangle Often extrapancreatic (duodenal); can be found anywhere in gland
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*Gastric acid hypersecretion, peptic ulcer, diarrhea, esophagitis, epigastric pain
*Gastric acid hypersecretion, peptic ulcer, diarrhea, esophagitis, epigastric pain
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*CgA, gastrin, PP (35%)
*CgA, gastrin, PP (35%)
|-
|-
| style="background:#DCDCDC; + | '''VIPoma (Verner– Morrison syndrome, WDHA)'''
| style="background:#DCDCDC; + " | '''VIPoma (Verner– Morrison syndrome, WDHA)'''
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*Distal pancreas (body and tail) Often spread outside pancreas
*Distal pancreas (body and tail) Often spread outside pancreas
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*Watery diarrhea, hypokalemia, achlorhydria (or acidosis)
*Watery diarrhea, hypokalemia, achlorhydria (or acidosis)
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*CgA, VIP
*CgA, VIP
|-
|-
| style="background:#DCDCDC; + | '''Glucagonoma'''
| style="background:#DCDCDC; + " | '''Glucagonoma'''
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*Body and tail of pancreas Often large and spread outside pancreas
*Body and tail of pancreas Often large and spread outside pancreas
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*Diabetes (hyperglycemia), necrolytic migratory erythema, stomatitis, glossitis, angular cheilitis
*Diabetes (hyperglycemia), necrolytic migratory erythema, stomatitis, glossitis, angular cheilitis
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*CgA, glucagon, glycentin
*CgA, glucagon, glycentin
|-
|-
| style="background:#DCDCDC; + | '''Somatostatinoma'''
| style="background:#DCDCDC; + " | '''Somatostatinoma'''
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*Pancreatoduodenal groove, ampullary, periampullary
*Pancreatoduodenal groove, ampullary, periampullary
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*Gallstones, diabetes (hyperglycemia), steatorrhea
*Gallstones, diabetes (hyperglycemia), steatorrhea
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*CgA, somatostatin
*CgA, somatostatin
|-
|-
| style="background:#DCDCDC; + | '''Ppoma'''
| style="background:#DCDCDC; + " | '''Ppoma'''
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*Head of pancreas
*Head of pancreas
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*None
*None
| style="background:#F5F5F5; + |  
| style="background:#F5F5F5; + " |  
*CgA, PP
*CgA, PP
|-
|-

Revision as of 20:24, 15 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]

Overview

A positive history of cigarette smoking, alcoholism, diabetes mellitus, chronic pancreatitis and family history of pancreatic cancer are considered as risk factors for developing Pancreatic cancer. The most common symptoms of Pancreatic cancer include mid-epigastric pain, jaundice, sudden unexplained weight loss and dark urine and light-colored or greasy stools are suggestive of Pancreatic cancer.

History and Symptoms

  • A positive history of cigarette smoking, alcoholism, diabetes mellitus, chronic pancreatitis and family history of pancreatic cancer are considered as risk factors for developing Pancreatic cancer. The most common symptoms of Pancreatic cancer include mid-epigastric pain, jaundice, sudden unexplained weight loss and dark urine and light-colored or greasy stools are suggestive of Pancreatic cancer.r.

History

  • Patients with Pancreatic cancer may have a positive history of:
    • Cigarette Smoking
    • Alcoholism
    • Diabetes mellitus
    • Chronic pancreatitis
    • Family history of pancreatic cancer

Common Symptoms

Common symptoms of Pancreatic cancer include:

  • Weight Loss (significant)
  • Jaundice
  • Midepigastric pain which may also radiate either to the lower back region and mid-back region.
  • Nausea
  • Vomiting
  • Malaise
  • Fatigue
  • Loss of appetite
  • Anorexia
  • Dyspepsia
  • Ascites
  • Dark urine
  • Light-colored or greasy stools

Less Common Symptoms

Less common symptoms of Pancreatic cancer include

  • Anxiety
  • Stress
  • Diabetes
  • Depression
  • Blood clots
  • Pruritis
  • Steatorrhea
  • Diarrhoea


  • Functional Pancreatic Neuroendocrine Tumors and their Characteristics are mentioned in the following table:[1]
Functional Pancreatic Neuroendocrine Tumors and their Characteristics
Tumor type and syndrome Location in pancreas Signs and symptoms Circulating biomarkers
Insulinoma (Whipple’s triad)
  • Head, body, tail (evenly distributed)
  • Hypoglycemia, dizziness, sweating, tachycardia, tremulousness, confusion, seizure
  • CgA and CgB, insulin inappropriate for blood glucose level, proinsulin, C-peptide
Gastrinoma (Zollinger–Ellison)
  • Gastrinoma triangle Often extrapancreatic (duodenal); can be found anywhere in gland
  • Gastric acid hypersecretion, peptic ulcer, diarrhea, esophagitis, epigastric pain
  • CgA, gastrin, PP (35%)
VIPoma (Verner– Morrison syndrome, WDHA)
  • Distal pancreas (body and tail) Often spread outside pancreas
  • Watery diarrhea, hypokalemia, achlorhydria (or acidosis)
  • CgA, VIP
Glucagonoma
  • Body and tail of pancreas Often large and spread outside pancreas
  • Diabetes (hyperglycemia), necrolytic migratory erythema, stomatitis, glossitis, angular cheilitis
  • CgA, glucagon, glycentin
Somatostatinoma
  • Pancreatoduodenal groove, ampullary, periampullary
  • Gallstones, diabetes (hyperglycemia), steatorrhea
  • CgA, somatostatin
Ppoma
  • Head of pancreas
  • None
  • CgA, PP

References

  1. ↑ Ryan DP, Hong TS, Bardeesy N (2014). "Pancreatic adenocarcinoma". N Engl J Med. 371 (11): 1039–49. doi:10.1056/NEJMra1404198. PMID 25207767.


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