Pancreatic cancer history and symptoms: Difference between revisions

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{{CMG}}; {{AE}} {{ARK}}
{{CMG}}; {{AE}} {{ARK}}
==Overview==
==Overview==
A positive history of cigarette [[smoking]], [[alcoholism]], [[diabetes mellitus]], chronic pancreatitis and family history of pancreatic cancer are considered as risk factors for developing Pancreatic cancer. The most common symptoms of Pancreatic cancer include mid-[[epigastric pain]], [[jaundice]], sudden unexplained [[weight loss]] and [[dark urine]] and light-colored or greasy stools are suggestive of Pancreatic cancer.
A positive history of cigarette [[smoking]], [[alcoholism]], [[diabetes mellitus]], [[chronic pancreatitis]] and [[family history]] of [[pancreatic cancer]] are considered as [[Risk factor|risk factors]] for developing [[pancreatic cancer]]. The most common symptoms of [[pancreatic cancer]] include mid-[[epigastric pain]], [[jaundice]], sudden unexplained [[weight loss]] and [[dark urine]] and [[Acholic stools|light-colored or greasy stools]] are suggestive of pancreatic cancer.


==History and Symptoms==
==History and Symptoms==
*A positive history of cigarette [[smoking]], [[alcoholism]], [[diabetes mellitus]], chronic pancreatitis and family history of pancreatic cancer are considered as risk factors for developing Pancreatic cancer. The most common symptoms of Pancreatic cancer include mid-[[epigastric pain]], [[jaundice]], sudden unexplained [[weight loss]] and [[dark urine]] and light-colored or greasy stools are suggestive of Pancreatic cancer.
*A positive history of cigarette [[smoking]], [[alcoholism]], [[diabetes mellitus]], chronic pancreatitis and family history of pancreatic cancer are considered as risk factors for developing Pancreatic cancer. The most common symptoms of [[pancreatic cancer]] include mid-[[epigastric pain]], [[jaundice]], sudden unexplained [[weight loss]] and [[dark urine]] and [[Acholic stools|light-colored or greasy stools]] are suggestive of [[Pancreatic cancer|pancreatic cancer.]]
===History===
===History===
*Patients with Pancreatic cancer may have a positive history of:
*Patients with [[pancreatic cancer]] may have a positive history of:
**Cigarette [[Smoking]]
**Cigarette [[Smoking]]
**[[Alcoholism]]
**[[Alcoholism]]
**[[Diabetes mellitus]]
**[[Diabetes mellitus]]
**[[Chronic pancreatitis]]
**[[Chronic pancreatitis]]
**Family history of pancreatic cancer
**[[Family history]] of [[pancreatic cancer]]


===Common Symptoms===
===Common Symptoms===
Common symptoms of Pancreatic cancer include:
Common [[Symptom|symptoms]] of [[pancreatic cancer]] include:
*Weight Loss (significant)
*[[Weight loss|Weight Loss]] (significant)
*[[Jaundice]]
*[[Jaundice]]
*Midepigastric pain which may also radiate either to the lower back region and mid-back region.
*[[Epigastric|Midepigastric]] [[pain]] which may also radiate either to the lower back region and mid-back region
*[[Nausea]]
*[[Nausea]]
*[[Vomiting]]
*[[Vomiting]]
*[[Malaise]]
*[[Malaise]]
*[[Fatigue]]
*[[Fatigue]]
*Loss of appetite
*[[Anorexia|Loss of appetite]]
*[[Anorexia]]
*[[Anorexia]]
*[[Dyspepsia]]
*[[Dyspepsia]]
*[[Ascites]]
*[[Ascites]]
*Dark urine
*Dark [[urine]]
*Light-colored or greasy stools
*[[Acholic stools|Light-colored or greasy stools]]


===Less Common Symptoms===
===Less Common Symptoms===
Less common symptoms of Pancreatic cancer include  
Less common [[Symptom|symptoms]] of [[pancreatic cancer]] include:
*[[Anxiety]]
*[[Anxiety]]
*[[Stress]]
*[[Stress]]
Line 56: Line 56:
*Head, body, tail (evenly distributed)
*Head, body, tail (evenly distributed)
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*Hypoglycemia, dizziness, sweating, tachycardia, tremulousness, confusion, seizure
*[[Hypoglycemia]], [[dizziness]], [[Perspiration|sweating]], [[tachycardia]], [[Tremor|tremulousness]], [[confusion]], [[seizure]]
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*CgA and CgB, insulin inappropriate for blood glucose level, proinsulin, C-peptide
*CgA and CgB, [[insulin]] inappropriate for [[Blood sugar|blood glucose]] level, [[proinsulin]], [[C-peptide]]
|-
|-
| style="background:#DCDCDC; + " | '''Gastrinoma (Zollinger–Ellison)'''
| style="background:#DCDCDC; + " | '''Gastrinoma (Zollinger–Ellison)'''
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*Gastrinoma triangle Often extrapancreatic (duodenal); can be found anywhere in gland
*[[Gastrinoma (patient information)|Gastrinoma]] triangle: Often extrapancreatic ([[Duodenum|duodenal]]); can be found anywhere in [[gland]]
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*Gastric acid hypersecretion, peptic ulcer, diarrhea, esophagitis, epigastric pain
*[[Gastric acid]] hypersecretion, [[peptic ulcer]], [[diarrhea]], [[esophagitis]], [[Abdominal pain|epigastric pain]]
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*CgA, gastrin, PP (35%)
*CgA, [[gastrin]], [[Pancreatic polypeptide|PP]] (35%)
|-
|-
| style="background:#DCDCDC; + " | '''VIPoma (Verner– Morrison syndrome, WDHA)'''
| style="background:#DCDCDC; + " | '''VIPoma (Verner– Morrison syndrome, WDHA)'''
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*Distal pancreas (body and tail) Often spread outside pancreas
*Distal [[pancreas]] (body and tail) Often spread outside [[pancreas]]
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*Watery diarrhea, hypokalemia, achlorhydria (or acidosis)
*[[Diarrhea|Watery diarrhea]], [[hypokalemia]], [[achlorhydria]] (or [[acidosis]])
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*CgA, VIP
*CgA, [[Vasoactive intestinal peptide|VIP]]
|-
|-
| style="background:#DCDCDC; + " | '''Glucagonoma'''
| style="background:#DCDCDC; + " | '''Glucagonoma'''
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*Body and tail of pancreas Often large and spread outside pancreas
*Body and tail of [[pancreas]]: Often large and spread outside [[pancreas]]
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*Diabetes (hyperglycemia), necrolytic migratory erythema, stomatitis, glossitis, angular cheilitis
*[[Diabetes]] ([[hyperglycemia]]), [[necrolytic migratory erythema]], [[stomatitis]], [[glossitis]], [[angular cheilitis]]
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*CgA, glucagon, glycentin
*CgA, [[glucagon]], glycentin
|-
|-
| style="background:#DCDCDC; + " | '''Somatostatinoma'''
| style="background:#DCDCDC; + " | '''Somatostatinoma'''
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*Pancreatoduodenal groove, ampullary, periampullary
*Pancreatoduodenal groove, [[Ampulla of Vater|ampullary]], periampullary
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*Gallstones, diabetes (hyperglycemia), steatorrhea
*[[Gallstone disease|Gallstones]], [[diabetes]] ([[hyperglycemia]]), [[steatorrhea]]
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*CgA, somatostatin
*CgA, [[somatostatin]]
|-
|-
| style="background:#DCDCDC; + " | '''Ppoma'''
| style="background:#DCDCDC; + " | '''Ppoma'''
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*Head of pancreas
*Head of [[pancreas]]
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*None
*None
| style="background:#F5F5F5; + " |  
| style="background:#F5F5F5; + " |  
*CgA, PP
*CgA, [[Pancreatic polypeptide|PP]]
|-
|-
|}
|}

Revision as of 03:33, 16 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]

Overview

A positive history of cigarette smoking, alcoholism, diabetes mellitus, chronic pancreatitis and family history of pancreatic cancer are considered as risk factors for developing pancreatic cancer. The most common symptoms of pancreatic cancer include mid-epigastric pain, jaundice, sudden unexplained weight loss and dark urine and light-colored or greasy stools are suggestive of pancreatic cancer.

History and Symptoms

History

Common Symptoms

Common symptoms of pancreatic cancer include:

Less Common Symptoms

Less common symptoms of pancreatic cancer include:


  • Functional Pancreatic Neuroendocrine Tumors and their Characteristics are mentioned in the following table:[1]
Functional Pancreatic Neuroendocrine Tumors and their Characteristics
Tumor type and syndrome Location in pancreas Signs and symptoms Circulating biomarkers
Insulinoma (Whipple’s triad)
  • Head, body, tail (evenly distributed)
Gastrinoma (Zollinger–Ellison)
VIPoma (Verner– Morrison syndrome, WDHA)
Glucagonoma
Somatostatinoma
  • Pancreatoduodenal groove, ampullary, periampullary
Ppoma
  • None

References

  1. ↑ Ryan DP, Hong TS, Bardeesy N (2014). "Pancreatic adenocarcinoma". N Engl J Med. 371 (11): 1039–49. doi:10.1056/NEJMra1404198. PMID 25207767.


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