Peptic ulcer causes: Difference between revisions
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==Overview== | ==Overview== | ||
Common causes of peptic ulcer disease include ''[[Helicobacter pylori]]'' infection and [[NSAID]] use. Less common causes of peptic ulcer disease include Crohn's disease, [[Zollinger-Ellison syndrome]], [[Cushing]] and [[Curling ulcers]], Carcinoid tumors, and [[carcinoid syndrome]]. | Common causes of [[peptic ulcer]] disease include ''[[Helicobacter pylori]]'' infection and [[NSAID]] use. Less common causes of [[peptic ulcer]] disease include [[Crohn's disease]], [[Zollinger-Ellison syndrome]], [[Cushing's Ulcer|Cushing]] and [[Curling ulcers]], [[Carcinoid tumors]], and [[carcinoid syndrome]]. | ||
==Causes== | ==Causes== | ||
===Common Causes | ===Common Causes<ref name="pmid19683340">{{cite journal| author=Malfertheiner P, Chan FK, McColl KE| title=Peptic ulcer disease. | journal=Lancet | year= 2009 | volume= 374 | issue= 9699 | pages= 1449-61 | pmid=19683340 | doi=10.1016/S0140-6736(09)60938-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19683340 }} </ref><ref name="pmid11960062">{{cite journal |vauthors=Hirschowitz BI, Lanas A |title=Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse |journal=J. Clin. Gastroenterol. |volume=34 |issue=5 |pages=523–8 |year=2002 |pmid=11960062 |doi= |url=}}</ref>=== | ||
*[[Helicobacter pylori]] | |||
*[[NSAID]]s | |||
Less common causes of peptic ulcer disease | Less common causes of [[peptic ulcer]] disease | ||
*Hormonal or mediator-induced including secondary acid hypersecretory states | *[[Hormonal]] or mediator-induced including secondary acid hypersecretory states | ||
**[[Gastrinomas]] | **[[Gastrinomas]] | ||
** [[Mastocytosis|Systemic mastocytosis]] | ** [[Mastocytosis|Systemic mastocytosis]] | ||
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** [[Myeloproliferative disease|Myeloproliferative disorder]] | ** [[Myeloproliferative disease|Myeloproliferative disorder]] | ||
*Antral g - cell hyperfunction | *Antral g - cell hyperfunction | ||
*Post-surgical -Antral exclusion and post gastric bypass surgery | *Post-surgical -Antral exclusion and post [[gastric]] bypass [[surgery]] | ||
*Tumors-cancers and [[lymphoma]] | *Tumors-cancers and [[lymphoma]] | ||
*Cameron [[ulcer]] (gastric ulcer where a [[hiatus hernia]] passes through the [[diaphragmatic hiatus]]) | *Cameron [[ulcer]] ([[gastric]] [[ulcer]] where a [[hiatus hernia]] passes through the [[diaphragmatic hiatus]]) | ||
*True idiopathic ulcer | *True idiopathic [[ulcer]] | ||
'''Rare causes of peptic ulcer disease''' | '''Rare causes of peptic ulcer disease''' | ||
* [[Crohn's disease|Crohn’s disease]] of the stomach or duodenum | * [[Crohn's disease|Crohn’s disease]] of the [[stomach]] or [[duodenum]] | ||
* [[Eosinophilic gastroduodenitis]] | * [[Eosinophilic gastroduodenitis]] | ||
* Systemic mastocytosis | * Systemic [[mastocytosis]] | ||
* Radiation damage | * [[Radiation]] damage | ||
* Viral infections (eg [[cytomegalovirus]] or [[Herpes simplex|herpes simplex infection]], in particular in immunocompromised patients) | * [[Viral infections]] (eg [[cytomegalovirus]] or [[Herpes simplex|herpes simplex infection]], in particular in [[immunocompromised]] patients) | ||
*Colonisation of stomach with H heilmanii | *Colonisation of [[stomach]] with H heilmanii | ||
* Severe systemic disease | * Severe [[systemic disease]] | ||
'''Genetic causes''' -<ref name="pmid17312377">{{cite journal| author=Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V et al.| title=Gastrinoma (duodenal and pancreatic). | journal=Neuroendocrinology | year= 2006 | volume= 84 | issue= 3 | pages= 173-82 | pmid=17312377 | doi=10.1159/000098009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17312377 }} </ref> | '''Genetic causes''' -<ref name="pmid17312377">{{cite journal| author=Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V et al.| title=Gastrinoma (duodenal and pancreatic). | journal=Neuroendocrinology | year= 2006 | volume= 84 | issue= 3 | pages= 173-82 | pmid=17312377 | doi=10.1159/000098009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17312377 }} </ref> | ||
*Peptic ulcer disease is caused by gastrinomas [[Zollinger-Ellison syndrome|(Zollinger-Ellison syndrome]])caused by a mutation in MEN gene present on chromosome 11q13. | *Peptic ulcer disease is caused by gastrinomas [[Zollinger-Ellison syndrome|(Zollinger-Ellison syndrome]])caused by a [[mutation]] in MEN [[gene]] present on [[chromosome]] 11q13. | ||
===Causes by Organ System=== | ===Causes by Organ System=== | ||
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|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Genetic''' | | '''Genetic''' | ||
| bgcolor="Beige" | [[Zollinger -Ellison syndrome]] associated with [[MEN TYPE 1]] syndrome caused by mutation in MEN gene present on chromosome 11q 13 | | bgcolor="Beige" | [[Zollinger -Ellison syndrome]] associated with [[MEN TYPE 1]] syndrome caused by mutation in MEN [[gene]] present on [[chromosome]] 11q 13 | ||
|- | |- | ||
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|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Pulmonary''' | | '''Pulmonary''' | ||
| bgcolor="Beige" | Sarcoidosis | | bgcolor="Beige" | [[Sarcoidosis]] | ||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Renal / Electrolyte''' | | '''Renal / Electrolyte''' | ||
| bgcolor="Beige" | Hypercalcemia | | bgcolor="Beige" | [[Hypercalcemia]] | ||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
Revision as of 22:05, 26 November 2017
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Peptic ulcer Microchapters |
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Diagnosis |
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Treatment |
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Surgery |
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Case Studies |
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2017 ACG Guidelines for Peptic Ulcer Disease |
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Guidelines for the Indications to Test for, and to Treat, H. pylori Infection |
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Guidlines for factors that predict the successful eradication when treating H. pylori infection |
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Guidelines to document H. pylori antimicrobial resistance in the North America |
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Guidelines for evaluation and testing of H. pylori antibiotic resistance |
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Guidelines for when to test for treatment success after H. pylori eradication therapy |
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Guidelines for penicillin allergy in patients with H. pylori infection |
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Peptic ulcer causes On the Web |
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American Roentgen Ray Society Images of Peptic ulcer causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ;Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Common causes of peptic ulcer disease include Helicobacter pylori infection and NSAID use. Less common causes of peptic ulcer disease include Crohn's disease, Zollinger-Ellison syndrome, Cushing and Curling ulcers, Carcinoid tumors, and carcinoid syndrome.
Causes
Common Causes[1][2]
Less common causes of peptic ulcer disease
- Hormonal or mediator-induced including secondary acid hypersecretory states
- Antral g - cell hyperfunction
- Post-surgical -Antral exclusion and post gastric bypass surgery
- Tumors-cancers and lymphoma
- Cameron ulcer (gastric ulcer where a hiatus hernia passes through the diaphragmatic hiatus)
- True idiopathic ulcer
Rare causes of peptic ulcer disease
- Crohn’s disease of the stomach or duodenum
- Eosinophilic gastroduodenitis
- Systemic mastocytosis
- Radiation damage
- Viral infections (eg cytomegalovirus or herpes simplex infection, in particular in immunocompromised patients)
- Colonisation of stomach with H heilmanii
- Severe systemic disease
Genetic causes -[3]
- Peptic ulcer disease is caused by gastrinomas (Zollinger-Ellison syndrome)caused by a mutation in MEN gene present on chromosome 11q13.
Causes by Organ System
Causes in Alphabetical Order
References
- ↑ Malfertheiner P, Chan FK, McColl KE (2009). "Peptic ulcer disease". Lancet. 374 (9699): 1449–61. doi:10.1016/S0140-6736(09)60938-7. PMID 19683340.
- ↑ Hirschowitz BI, Lanas A (2002). "Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse". J. Clin. Gastroenterol. 34 (5): 523–8. PMID 11960062.
- ↑ Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V; et al. (2006). "Gastrinoma (duodenal and pancreatic)". Neuroendocrinology. 84 (3): 173–82. doi:10.1159/000098009. PMID 17312377.
- ↑ Kutlubay Z, Zara T, Engin B, Serdaroğlu S, Tüzün Y, Yilmaz E; et al. (2014). "Helicobacter pylori infection and skin disorders". Hong Kong Med J. 20 (4): 317–24. doi:10.12809/hkmj134174. PMID 25045884.
- ↑