Thalassemia history and symptoms: Difference between revisions
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==Symptoms== | ==Symptoms== | ||
*'''Fatigue''': This is the most common symptom of thalassemia. Fatigue is due to impaired oxygen delivery to peripheral tissues. Fatigue is commonly the first presenting symptoms and can occur early in childhood. Typically, fatigue is the symptoms that prompts additional workup that leads to a diagnosis of thalassemia. | *'''Fatigue''': This is the most common symptom of thalassemia. Fatigue is due to impaired oxygen delivery to peripheral tissues. Fatigue is commonly the first presenting symptoms and can occur early in childhood. Typically, fatigue is the symptoms that prompts additional workup that leads to a diagnosis of thalassemia. | ||
*'''Bone deformities in the face''': | *'''Bone deformities in the face''': Bone deformities can occur in severe forms of thalassemia, such as beta-thalassemia major, or [[Cooley's anemia]]. Bone deformities are to due to the occurrence of [[hematopoiesis]] in bone marrow of bones other than the iliac crest, long bones, or sterum, where most of the bone marrow is normally located. Bone deformities in the face can occur in children at an early age. | ||
*'''Growth failure''': | *'''Growth failure''': Growth failure is another common presenting symptoms for severe thalassemias. Growth failure is due to the increased cardiac workload (increased stroke volume and heart rate), which is a compensatory response to the impaired oxygen carrying capacity of defective globin chains. | ||
*'''Shortness of breath''': | *'''Shortness of breath''': | ||
*'''Yellow skin (jaundice)''': | *'''Yellow skin (jaundice)''': |
Revision as of 00:05, 20 November 2017
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Overview
History
Patients with thalassemia usually have a family history of thalassemia. The defective alpha- or beta-globin chain can be inherited from a patient's mother or father. In the case of severe thalassemia, symptoms begin early in life.
Symptoms
- Fatigue: This is the most common symptom of thalassemia. Fatigue is due to impaired oxygen delivery to peripheral tissues. Fatigue is commonly the first presenting symptoms and can occur early in childhood. Typically, fatigue is the symptoms that prompts additional workup that leads to a diagnosis of thalassemia.
- Bone deformities in the face: Bone deformities can occur in severe forms of thalassemia, such as beta-thalassemia major, or Cooley's anemia. Bone deformities are to due to the occurrence of hematopoiesis in bone marrow of bones other than the iliac crest, long bones, or sterum, where most of the bone marrow is normally located. Bone deformities in the face can occur in children at an early age.
- Growth failure: Growth failure is another common presenting symptoms for severe thalassemias. Growth failure is due to the increased cardiac workload (increased stroke volume and heart rate), which is a compensatory response to the impaired oxygen carrying capacity of defective globin chains.
- Shortness of breath:
- Yellow skin (jaundice):
Persons with the minor form of alpha and beta thalassemia have small red blood cells but no symptoms.