Alpha 1-antitrypsin deficiency historical perspective: Difference between revisions
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==Historical Perspective== | ==Historical Perspective== | ||
*In 1963, Carl-Bertil Laurell (1919–2001) and Eriksson at the University of Lund, Sweden was the first to discover A1AD at the General Hospital in Malmö, Sweden.<ref name=Laurell_1963>{{cite journal | author = Laurell CB, Eriksson S | title = The electrophoretic alpha 1-globulin pattern of serum in alpha 1-antitrypsin deficiency | journal = Scand J Clin Lab Invest | year = 1963 | volume = 15 | issue = | pages = 132–140 | url= }}</ref><ref name=Sharp_1969>{{cite journal | author = Sharp H, Bridges R, Krivit W, Freier E | title = Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder. | journal = J Lab Clin Med | volume = 73 | issue = 6 | pages = 934-9 | year = 1969 | id = PMID 4182334}}</ref> | *In 1963, Carl-Bertil Laurell (1919–2001) and Eriksson at the University of Lund, Sweden was the first to discover A1AD at the General Hospital in Malmö, Sweden.<ref name=Laurell_1963>{{cite journal | author = Laurell CB, Eriksson S | title = The electrophoretic alpha 1-globulin pattern of serum in alpha 1-antitrypsin deficiency | journal = Scand J Clin Lab Invest | year = 1963 | volume = 15 | issue = | pages = 132–140 | url= }}</ref><ref name=Sharp_1969>{{cite journal | author = Sharp H, Bridges R, Krivit W, Freier E | title = Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder. | journal = J Lab Clin Med | volume = 73 | issue = 6 | pages = 934-9 | year = 1969 | id = PMID 4182334}}</ref> | ||
*Laurell, along with a medical resident, Sten Eriksson, made the discovery after | *Laurell, along with a medical resident, Sten Eriksson, made the discovery after observing the absence of the α<sub>1</sub> band on protein [[electrophoresis]] in five of 1500 samples; three of the five patient samples were found to have developed emphysema at a young age. | ||
*In 1969, Sharp ''et al'' was the first to discover the association between liver disease and development of A1AD. | *In 1969, Sharp ''et al'' was the first to discover the association between liver disease and development of A1AD. | ||
Revision as of 18:40, 20 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]Cafer Zorkun, M.D., Ph.D. [3]
Overview
Alpha 1-antitrypsin deficiency (A1AD) is a relatively new disease. It was discovered in 1963 by Carl-Bertil Laurell (1919–2001) and Eriksson at the University of Lund, Sweden.
Historical Perspective
- In 1963, Carl-Bertil Laurell (1919–2001) and Eriksson at the University of Lund, Sweden was the first to discover A1AD at the General Hospital in Malmö, Sweden.[1][2]
- Laurell, along with a medical resident, Sten Eriksson, made the discovery after observing the absence of the α1 band on protein electrophoresis in five of 1500 samples; three of the five patient samples were found to have developed emphysema at a young age.
- In 1969, Sharp et al was the first to discover the association between liver disease and development of A1AD.
References
- ↑ Laurell CB, Eriksson S (1963). "The electrophoretic alpha 1-globulin pattern of serum in alpha 1-antitrypsin deficiency". Scand J Clin Lab Invest. 15: 132&ndash, 140.
- ↑ Sharp H, Bridges R, Krivit W, Freier E (1969). "Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder". J Lab Clin Med. 73 (6): 934–9. PMID 4182334.