Chronic lymphocytic leukemia differential diagnosis: Difference between revisions

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Revision as of 21:23, 29 August 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Chronic lymphocytic leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.^[1]

Differenting Chronic lymphocytic leukemia from other Diseases

Chronic lymphocytic leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.
Based on the expression of cell surface markers, the table below differentiates chronic lymphocytic leukemia from other diseases that cause similar clinical presentations:^[1]


Differential Diagnosis	Surface Immunoglobulin	CD5	CD22/FMC7	CD23	CD79b	CD103

Chronic lymphocytic leukemia	Weakly positive	Positive	Negative	Positive	Negative	Positive/Negative
Prolymphocytic leukemia	Strongly positive	Negative	Positive	Negative	Positive	Negative
Hairy cell leukemia	Strongly positive	Negative	Positive	Negative	Positive/Negative	Positive
Mantle cell lymphoma	Positive	Positive	Strongly positive	Negative	Strongly positive	Negative
Follicular lymphoma	Strongly positive	Negative	Positive	Negative	Strongly positive	Negative

Chronic lymphocytic leukemia must also be differentiated from other causes of fever, hepatosplenomegaly, and lymph node swelling such as:^[2]

References

↑ ^1.0 ^1.1 Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011
↑ Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015

Template:Hematology

Template:WikiDoc Sources

[H-1] 1.0 ^1.1 Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011

[wiki-2] Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015

[1]

[2]

@@ Line 3: / Line 3: @@
 {{CMG}} {{AE}}{{HL}}
 ==Overview==
-* Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].<ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
+* Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], [[Prolymphocytic leukemia|prolymphocytic leukaemia]], [[follicular lymphoma]], and [[mantle cell lymphoma]].<ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
 ==Differenting Chronic lymphocytic leukemia from other Diseases==
@@ Line 10: / Line 10: @@
 <br>
 {| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
-|valign=top|
+| valign="top" |
 |+
 ! style="background: #4479BA; width: 600px;" | {{fontcolor|#FFF|'''Differential Diagnosis'''}}
@@ Line 24: / Line 24: @@
 | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
 '''Chronic lymphocytic leukemia'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Weakly positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center |
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Negative'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Negative'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Positive/Negative'''
@@ Line 40: / Line 40: @@
 | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
-'''Prolymphocytic leukemia'''
+'''[[Prolymphocytic leukemia]]'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Strongly positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Negative'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Negative'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Negative'''
@@ Line 57: / Line 57: @@
 | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
-'''Hairy cell leukemia'''
+'''[[Hairy cell leukemia]]'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Strongly positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Negative'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Negative'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Positive/Negative'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Positive'''
@@ Line 74: / Line 74: @@
 | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
-'''Mantle cell lymphoma'''
+'''[[Mantle cell lymphoma]]'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Strongly positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Negative'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Strongly positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Negative'''
@@ Line 91: / Line 91: @@
 | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
-'''Follicular lymphoma'''
+'''[[Follicular lymphoma]]'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Strongly positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Negative'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Negative'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Strongly positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
 '''Negative'''
 |}

v t e Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208)
CFU-GM/ and other granulocytes	Template:Navbox subgroup
MEP	Template:Navbox subgroup
CFU-Mast	Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis)
Multiple/unknown	AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) · MP (Myelofibrosis) · Acute biphenotypic leukaemia
See also hematology, lymphoid malignancy

Chronic lymphocytic leukemia differential diagnosis: Difference between revisions

Revision as of 21:23, 29 August 2018

Overview

Differenting Chronic lymphocytic leukemia from other Diseases

References

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