Chronic myelogenous leukemia staging: Difference between revisions

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==Classification==
==Classification==
Chronic myelogenous leukemia is often divided into three phases based on clinical characteristics and laboratory findings.<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/staging/?region=ab</ref><ref>{{cite journal | author = Vardiman J, Harris N, Brunning R | title = The World Health Organization (WHO) classification of the myeloid neoplasms. | journal = Blood | volume = 100 | issue = 7 | pages = 2292-302 | year = 2002 |pmid=12239137|url=http://www.bloodjournal.org/cgi/content/full/100/7/2292|accessdate=2007-09-22}}</ref>
Chronic myelogenous leukemia is often divided into three phases based on clinical characteristics and laboratory findings.<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/staging/?region=ab</ref><ref>{{cite journal | author = Vardiman J, Harris N, Brunning R | title = The World Health Organization (WHO) classification of the myeloid neoplasms. | journal = Blood | volume = 100 | issue = 7 | pages = 2292-302 | year = 2002 |pmid=12239137|url=http://www.bloodjournal.org/cgi/content/full/100/7/2292|accessdate=2007-09-22}}</ref>
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Phases}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Associations}}
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Chronic phase
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*Most patients (85%) are diagnosed in this phase
*Less than 10% of cells in the blood and bone marrow are blasts
*Usually asymptomatic or mild symptoms my present
*Progress slowly
*Respond well to treatment
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
Accelerated phase
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*According to the [[World Health Organization]] diagnostic criteria, patient is considered to be in the accelerated phase if any of the following is present:
:*10&ndash;19% [[myeloblast]]s in the blood or [[bone marrow]]
:*>20% [[basophil]]s in the blood or bone marrow
:*[[Platelet]] count <100,000, unrelated to therapy
:*Platelet count >1,000,000, unresponsive to therapy
:*Cytogenetic evolution with new abnormalities in addition to the Philadelphia chromosome
:*[[Splenomegaly]] or increasing white blood cell count, unresponsive to therapy
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
Blast or acute phase
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*Disease acts more like an acute leukemia
*30% of cells in blood and bone marrow are blast
*Blast cells often spread to tissues and organs outside the bone marrow
*Usually symptomatic
*Bleeding and infections are common
*Blast crisis may occur
:*The accelerated phase can change quickly into the blast phase with symptoms of fever, malaise, and [[splenomegaly]]
|}
==References==
==References==



Revision as of 19:25, 19 April 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

Chronic myelogenous leukemia may be classified according to the clinical characteristics and laboratory findings into three subtypes: chronic phase, accelerated phase, and blast crisis.

Classification

Chronic myelogenous leukemia is often divided into three phases based on clinical characteristics and laboratory findings.[1][2]

References

  1. Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/staging/?region=ab
  2. Vardiman J, Harris N, Brunning R (2002). "The World Health Organization (WHO) classification of the myeloid neoplasms". Blood. 100 (7): 2292–302. PMID 12239137. Retrieved 2007-09-22.


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