Mycosis fungoides natural history, complications and prognosis: Difference between revisions

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* Lymphoma has spread to lymph nodes  
* Lymphoma has spread to lymph nodes  
* Lymphoma has spread to other organs
* Lymphoma has spread to other organs
==Staging==
The staging of cutaneous T cell lymphoma is based on skin and lymph node involvement.<ref name= canadiancancer> Cutaneous T cell lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/cutaneous-t-cell-lymphoma/?region=on Accessed on January 19, 2016</ref> Staging for cutaneous T cell lymphoma  is provided in the following table:
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
|+ '''Staging of cutaneous T cell lymphoma <ref name= canadiancancer> Cutaneous T cell lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/cutaneous-t-cell-lymphoma/?region=on Accessed on January 19, 2016</ref>'''
! style="background: #4479BA; color:#FFF;" | Stage
! style="background: #4479BA; color:#FFF;" | Involvement
|-
| style="padding: 5px 5px; background: #DCDCDC;" colspan=3 | '''stage I'''
|-
| style="padding: 5px 5px; background: #F5F5F5;" | I A
| style="padding: 5px 5px; background: #F5F5F5;" |
* Less than 10% of the skin is covered with patches or plaques
|-
| style="padding: 5px 5px; background: #F5F5F5;" | I B
| style="padding: 5px 5px; background: #F5F5F5;" |
* 10% or more of the skin is covered with patches or plaques
|-
| style="padding: 5px 5px; background: #DCDCDC;" colspan=3 | '''stage II'''
|-
| style="padding: 5px 5px; background: #F5F5F5;" | II A
| style="padding: 5px 5px; background: #F5F5F5;" |
* Any amount of the skin is covered in patches or plaques
* Lymph nodes are enlarged, but do not contain cancer
|-
| style="padding: 5px 5px; background: #F5F5F5;" | II B
| style="padding: 5px 5px; background: #F5F5F5;" |
* There is one or more raised tumors on the skin
* Lymph nodes may or may not be enlarged and do not contain cancer
|-
| style="padding: 5px 5px; background: #DCDCDC;" colspan=3 | '''stage III'''
|-
| style="padding: 5px 5px; background: #F5F5F5;" | III
| style="padding: 5px 5px; background: #F5F5F5;" |
* Almost all of the skin is reddened
* There may or may not be patches, plaques or skin tumors
* Lymph nodes may or may not be enlarged and do not contain cancer
|-
| style="padding: 5px 5px; background: #DCDCDC;" colspan=3 | '''stage IV'''
|-
| style="padding: 5px 5px; background: #F5F5F5;" | IV A
| style="padding: 5px 5px; background: #F5F5F5;" |
* Cancer has spread to the lymph nodes, but not to other organs in the body
|-
| style="padding: 5px 5px; background: #F5F5F5;" | IV B
| style="padding: 5px 5px; background: #F5F5F5;" |
* Cancer has spread to other organs in the body, including the blood and bone marrow
* Lymph nodes may be enlarged and may contain cancer
|}


==References==
==References==

Revision as of 15:03, 30 October 2018

Cutaneous T cell lymphoma Microchapters

Home

Patient Information

Overview

Classification

Mycosis fungoides
Sezary syndrome

Pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

If left untreated, cutaneous T cell lymphoma may progress to develop cutaneous patches, plaque, and tumors. Depending on the extent of the lymphoma at the time of diagnosis, the prognosis may vary.

Natural History

  • Mycosis fungoides is initially an indolent lymphoma that may later develop peripheral lymphadenopathy and can finally progress to widespread visceral involvement.[1]
  • Cutaneous T cell lymphoma is usually initially seen by dermatologists with patients presenting with skin lesions.
  • Patients often have a history of several years of eczematous or dermatitic skin lesions before the diagnosis is finally established.
  • The skin lesions then progress from the patch stage to the plaque stage to cutaneous tumors.

Prognosis

  • Cutaneous T cell lymphoma is usually a slow-growing (indolent) lymphoma.[2]
  • The prognosis for people with cutaneous T cell lymphoma is based on the extent of disease and how the person responds to treatment.
  • Although more advanced stages of cutaneous T cell lymphoma may not be cured, the lymphoma can still be controlled with treatment.

Favorable prognosis

  • Early stage disease
  • Lymphoma is confined to the skin

Unfavorable prognosis

  • More advanced disease
  • Lymphoma has spread to lymph nodes
  • Lymphoma has spread to other organs


Staging

The staging of cutaneous T cell lymphoma is based on skin and lymph node involvement.[2] Staging for cutaneous T cell lymphoma is provided in the following table:

Staging of cutaneous T cell lymphoma [2]
Stage Involvement
stage I
I A
  • Less than 10% of the skin is covered with patches or plaques
I B
  • 10% or more of the skin is covered with patches or plaques
stage II
II A
  • Any amount of the skin is covered in patches or plaques
  • Lymph nodes are enlarged, but do not contain cancer
II B
  • There is one or more raised tumors on the skin
  • Lymph nodes may or may not be enlarged and do not contain cancer
stage III
III
  • Almost all of the skin is reddened
  • There may or may not be patches, plaques or skin tumors
  • Lymph nodes may or may not be enlarged and do not contain cancer
stage IV
IV A
  • Cancer has spread to the lymph nodes, but not to other organs in the body
IV B
  • Cancer has spread to other organs in the body, including the blood and bone marrow
  • Lymph nodes may be enlarged and may contain cancer


References

  1. ↑ Mycosis fungoides. Radiopaedia.http://radiopaedia.org/articles/mycosis-fungoides Accessed on January 20, 2016
  2. ↑ 2.0 2.1 2.2 Cutaneous T cell lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/cutaneous-t-cell-lymphoma/?region=on Accessed on January 19, 2016


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