Hepatocellular carcinoma other diagnostic studies: Difference between revisions
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==Key Findings in biopsy in Hepatocellular Carcinoma== | ==Key Findings in biopsy in Hepatocellular Carcinoma== | ||
The diagnosis of hepatocellular carcinoma is confirmed by [[percutaneous]] [[biopsy]] and histopathologic analysis. | The diagnosis of hepatocellular carcinoma is confirmed by [[percutaneous]] [[biopsy]] and histopathologic analysis. | ||
===Hepatic venous pressure gradient measurement=== | |||
*Hepatic venous pressure gradient (HVPG) measurement is the difference between [[Hepatic vein|hepatic venous]] [[wedge pressure]] (HVWP) and free [[Hepatic vein|hepatic venous]] pressure (FHVP). | |||
*HVPG reflects the intra-[[sinusoidal]] [[pressure]].<ref name="pmid16496346">{{cite journal |vauthors=Boyer TD |title=Wedged hepatic vein pressure (WHVP): ready for prime time |journal=Hepatology |volume=43 |issue=3 |pages=405–6 |year=2006 |pmid=16496346 |doi=10.1002/hep.21118 |url=}}</ref> | |||
*The HVPG of over 10 mmHg is associated with a 6-fold increase of HCC risk.<ref name="pmid19303163">{{cite journal |vauthors=Ripoll C, Groszmann RJ, Garcia-Tsao G, Bosch J, Grace N, Burroughs A, Planas R, Escorsell A, Garcia-Pagan JC, Makuch R, Patch D, Matloff DS |title=Hepatic venous pressure gradient predicts development of hepatocellular carcinoma independently of severity of cirrhosis |journal=J. Hepatol. |volume=50 |issue=5 |pages=923–8 |year=2009 |pmid=19303163 |doi=10.1016/j.jhep.2009.01.014 |url=}}</ref> | |||
*HVPG is measured through insertion of a [[catheter]] in right [[internal jugular vein]].<ref name="pmid22223943">{{cite journal| author=Chelliah ST, Keshava SN, Moses V, Surendrababu NR, Zachariah UG, Eapen C| title=Measurement of hepatic venous pressure gradient revisited: Catheter wedge vs balloon wedge techniques. | journal=Indian J Radiol Imaging | year= 2011 | volume= 21 | issue= 4 | pages= 291-3 | pmid=22223943 | doi=10.4103/0971-3026.90693 | pmc=3249946 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22223943 }}</ref> | |||
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==References== | ==References== | ||
Revision as of 15:22, 11 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Other diagnostic studies for hepatocellular carcinoma include laparoscopy and biopsy.
Key Findings in biopsy in Hepatocellular Carcinoma
The diagnosis of hepatocellular carcinoma is confirmed by percutaneous biopsy and histopathologic analysis.
Hepatic venous pressure gradient measurement
- Hepatic venous pressure gradient (HVPG) measurement is the difference between hepatic venous wedge pressure (HVWP) and free hepatic venous pressure (FHVP).
- HVPG reflects the intra-sinusoidal pressure.[1]
- The HVPG of over 10 mmHg is associated with a 6-fold increase of HCC risk.[2]
- HVPG is measured through insertion of a catheter in right internal jugular vein.[3]
{{#ev:youtube|9cEOpr-MRL4|500}}
References
- ↑ Boyer TD (2006). "Wedged hepatic vein pressure (WHVP): ready for prime time". Hepatology. 43 (3): 405–6. doi:10.1002/hep.21118. PMID 16496346.
- ↑ Ripoll C, Groszmann RJ, Garcia-Tsao G, Bosch J, Grace N, Burroughs A, Planas R, Escorsell A, Garcia-Pagan JC, Makuch R, Patch D, Matloff DS (2009). "Hepatic venous pressure gradient predicts development of hepatocellular carcinoma independently of severity of cirrhosis". J. Hepatol. 50 (5): 923–8. doi:10.1016/j.jhep.2009.01.014. PMID 19303163.
- ↑ Chelliah ST, Keshava SN, Moses V, Surendrababu NR, Zachariah UG, Eapen C (2011). "Measurement of hepatic venous pressure gradient revisited: Catheter wedge vs balloon wedge techniques". Indian J Radiol Imaging. 21 (4): 291–3. doi:10.4103/0971-3026.90693. PMC 3249946. PMID 22223943.