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{{SK}} Lymphoid leukaemia
==Overview==


==[[Lymphoid leukemia overview|Overview]]==
==Classification==
==[[Lymphoid leukemia historical perspective|Historical Perspective]]==
The '''World Health Organization''' ('''WHO''') classifications and '''French-American-British''' ('''FAB''') for acute lymphoblastic leukemia (ALL) are provided below.<ref name="pmid26980727">{{cite journal |vauthors=Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES |title=The 2016 revision of the World Health Organization classification of lymphoid neoplasms |journal=Blood |volume=127 |issue=20 |pages=2375–90 |date=May 2016 |pmid=26980727 |pmc=4874220 |doi=10.1182/blood-2016-01-643569 |url=}}</ref>
<ref name="pmid10643532">{{cite journal |vauthors=Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD |title=The World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. Report of the Clinical Advisory Committee meeting, Airlie House, Virginia, November, 1997 |journal=Ann. Oncol. |volume=10 |issue=12 |pages=1419–32 |date=December 1999 |pmid=10643532 |doi= |url=}}</ref><ref name="pmid1">{{cite journal |vauthors=Makar AB, McMartin KE, Palese M, Tephly TR, Schmoldt A, Benthe HF, Haberland G, Anke H, Spector LB |title=Formate assay in body fluids: application in methanol poisoning |journal=Biochem Med |volume=13 |issue=2 |pages=117–26 |date=June 1975 |pmid=1 |pmc=5922622 |doi= |url=}}</ref><ref name="pmid27161658">{{cite journal |vauthors=Wang Y, Miller S, Roulston D, Bixby D, Shao L |title=Genome-Wide Single-Nucleotide Polymorphism Array Analysis Improves Prognostication of Acute Lymphoblastic Leukemia/Lymphoma |journal=J Mol Diagn |volume=18 |issue=4 |pages=595–603 |date=July 2016 |pmid=27161658 |doi=10.1016/j.jmoldx.2016.03.004 |url=}}</ref>
*WHO classification of acute lymphoblastic leukemia
**B lymphoblastic leukemia/lymphoma:
***B lymphoblastic leukemia/lymphoma, NOS


==[[Lymphoid leukemia classification|Classification]]==
**B lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities:
***B lymphoblastic leukemia/lymphoma with [[t(9;22)]](q34;q11.2), BCR-ABL1<ref name="pmid26514535">{{cite journal |vauthors=Goud TM, Al Salmani KK, Al Harasi SM, Al Musalhi M, Wasifuddin SM, Rajab A |title=Importance of FISH combined with Morphology, Immunophenotype and Cytogenetic Analysis of Childhood/ Adult Acute Lymphoblastic Leukemia in Omani Patients |journal=Asian Pac. J. Cancer Prev. |volume=16 |issue=16 |pages=7343–50 |date=2015 |pmid=26514535 |doi= |url=}}</ref>
***B lymphoblastic leukemia/lymphoma with t(v;11q23); MLL rearranged<ref name="pmid16478880">{{cite journal |vauthors=Nagayama J, Tomizawa D, Koh K, Nagatoshi Y, Hotta N, Kishimoto T, Takahashi Y, Kuno T, Sugita K, Sato T, Kato K, Ogawa A, Nakahata T, Mizutani S, Horibe K, Ishii E |title=Infants with acute lymphoblastic leukemia and a germline MLL gene are highly curable with use of chemotherapy alone: results from the Japan Infant Leukemia Study Group |journal=Blood |volume=107 |issue=12 |pages=4663–5 |date=June 2006 |pmid=16478880 |doi=10.1182/blood-2005-11-4728 |url=}}</ref>
***B lymphoblastic leukemia/lymphoma with t(12;21)(p13;q22) TEL-AML1 (ETV6-RUNX1)<ref name="pmid19594616">{{cite journal |vauthors=Peter A, Heiden T, Taube T, Körner G, Seeger K |title=Interphase FISH on TEL/AML1 positive acute lymphoblastic leukemia relapses--analysis of clinical relevance of additional TEL and AML1 copy number changes |journal=Eur. J. Haematol. |volume=83 |issue=5 |pages=420–32 |date=November 2009 |pmid=19594616 |doi=10.1111/j.1600-0609.2009.01315.x |url=}}</ref>
***B lymphoblastic leukemia/lymphoma with hyperdiploidy
***B lymphoblastic leukemia/lymphoma with hypodiploidy<ref name="pmid10512165">{{cite journal |vauthors=Greipp PR, Trendle MC, Leong T, Oken MM, Kay NE, Van Ness B, Kyle RA |title=Is flow cytometric DNA content hypodiploidy prognostic in multiple myeloma? |journal=Leuk. Lymphoma |volume=35 |issue=1-2 |pages=83–9 |date=September 1999 |pmid=10512165 |doi=10.3109/10428199909145707 |url=}}</ref>
***B lymphoblastic leukemia/lymphoma with t(5;14)(q31;q32) IL3-IGH
***B lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3) TCF3-PBX1


==[[Lymphoid leukemia pathophysiology|Pathophysiology]]==
**T lymphoblastic leukemia/lymphoma:
==[[Lymphoid leukemia causes|Causes]]==
***FAB classification of acute lymphoblastic leukemia (for historical purposes):<ref name="pmid28052366">{{cite journal |vauthors=Canaani J, Beohou E, Labopin M, Socié G, Huynh A, Volin L, Cornelissen J, Milpied N, Gedde-Dahl T, Deconinck E, Fegueux N, Blaise D, Mohty M, Nagler A |title=Impact of FAB classification on predicting outcome in acute myeloid leukemia, not otherwise specified, patients undergoing allogeneic stem cell transplantation in CR1: An analysis of 1690 patients from the acute leukemia working party of EBMT |journal=Am. J. Hematol. |volume=92 |issue=4 |pages=344–350 |date=April 2017 |pmid=28052366 |doi=10.1002/ajh.24640 |url=}}</ref>
==[[Lymphoid leukemia differential diagnosis|Differentiating Lymphoid leukemia from other Diseases]]==
****ALL-L1: Small cells with homogeneous nuclear chromatin, a regular nuclear shape, small or no nucleoli, scanty cytoplasm, and mild to moderate basophilia
==[[Lymphoid leukemia epidemiology and demographics|Epidemiology and Demographics]]==
****ALL-L2: Large, heterogeneous cells with variable nuclear chromatin, an irregular nuclear shape, 1 or more nucleoli, a variable amount of cytoplasm, and variable basophilia
****ALL-L3: Large, homogeneous cells with fine, stippled chromatin; regular nuclei; prominent nucleoli; and abundant, deeply basophilic cytoplasm. The most distinguishing feature is prominent cytoplasmic vacuolation.
==Pathophysiology==


==[[Lymphoid leukemia risk factors|Risk Factors]]==


==[[Lymphoid leukemia screening|Screening]]==
==References==
 
{{Reflist|2}}
==[[Lymphoid leukemia natural history|Natural History, Complications and Prognosis]]==
 
==Diagnosis==
[[Lymphoid leukemia staging|Staging]] | [[Lymphoid leukemia history and symptoms|History and Symptoms]] | [[Lymphoid leukemia physical examination|Physical Examination]] |  [[Lymphoid leukemia laboratory tests|Laboratory Findings]] | [[Lymphoid leukemia electrocardiogram|Electrocardiogram]] | [[Lymphoid leukemia chest x ray|Chest X Ray]] | [[Lymphoid leukemia CT|CT]] | [[Lymphoid leukemia MRI|MRI]] | [[Lymphoid leukemia echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Lymphoid leukemia other imaging findings|Other Imaging Findings]] | [[Lymphoid leukemia other diagnostic studies|Other Diagnostic Studies]]
 
==Treatment==
[[Lymphoid leukemia medical therapy|Medical Therapy]] | [[Lymphoid leukemia surgery|Surgery]] | [[Lymphoid leukemia primary prevention|Primary Prevention]] | [[Lymphoid leukemia secondary prevention|Secondary Prevention]] | [[Lymphoid leukemia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Lymphoid leukemia future or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
[[Lymphoid leukemia case study one|Case #1]]
 
==Related chapters==
* [[Acute lymphoblastic leukemia]]
* [[Chronic lymphocytic leukemia]]
* [[T-cell leukemia]]
* [[B-cell leukemia]]
 
{{Hematology}}
{{Hematological malignancy histology}}
 
[[Category:Disease]]
[[Category:Types of cancer]]
[[Category:Oncology]]
[[Category:Hematology]]
 
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Revision as of 16:15, 5 December 2018

For patient information, click here

Lymphoid leukemia
ICD-10 C91
ICD-9 204
MeSH D007945

Lymphoid leukemia Main Page

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Patient Information

Overview

Classification

Pathophysiology

Differentiating Lymphoid Lymphoma

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Classification

The World Health Organization (WHO) classifications and French-American-British (FAB) for acute lymphoblastic leukemia (ALL) are provided below.[1] [2][3][4]

  • WHO classification of acute lymphoblastic leukemia
    • B lymphoblastic leukemia/lymphoma:
      • B lymphoblastic leukemia/lymphoma, NOS
    • B lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities:
      • B lymphoblastic leukemia/lymphoma with t(9;22)(q34;q11.2), BCR-ABL1[5]
      • B lymphoblastic leukemia/lymphoma with t(v;11q23); MLL rearranged[6]
      • B lymphoblastic leukemia/lymphoma with t(12;21)(p13;q22) TEL-AML1 (ETV6-RUNX1)[7]
      • B lymphoblastic leukemia/lymphoma with hyperdiploidy
      • B lymphoblastic leukemia/lymphoma with hypodiploidy[8]
      • B lymphoblastic leukemia/lymphoma with t(5;14)(q31;q32) IL3-IGH
      • B lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3) TCF3-PBX1
    • T lymphoblastic leukemia/lymphoma:
      • FAB classification of acute lymphoblastic leukemia (for historical purposes):[9]
        • ALL-L1: Small cells with homogeneous nuclear chromatin, a regular nuclear shape, small or no nucleoli, scanty cytoplasm, and mild to moderate basophilia
        • ALL-L2: Large, heterogeneous cells with variable nuclear chromatin, an irregular nuclear shape, 1 or more nucleoli, a variable amount of cytoplasm, and variable basophilia
        • ALL-L3: Large, homogeneous cells with fine, stippled chromatin; regular nuclei; prominent nucleoli; and abundant, deeply basophilic cytoplasm. The most distinguishing feature is prominent cytoplasmic vacuolation.

Pathophysiology

References

  1. ↑ Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES (May 2016). "The 2016 revision of the World Health Organization classification of lymphoid neoplasms". Blood. 127 (20): 2375–90. doi:10.1182/blood-2016-01-643569. PMC 4874220. PMID 26980727.
  2. ↑ Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD (December 1999). "The World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. Report of the Clinical Advisory Committee meeting, Airlie House, Virginia, November, 1997". Ann. Oncol. 10 (12): 1419–32. PMID 10643532.
  3. ↑ Makar AB, McMartin KE, Palese M, Tephly TR, Schmoldt A, Benthe HF, Haberland G, Anke H, Spector LB (June 1975). "Formate assay in body fluids: application in methanol poisoning". Biochem Med. 13 (2): 117–26. PMC 5922622. PMID 1.
  4. ↑ Wang Y, Miller S, Roulston D, Bixby D, Shao L (July 2016). "Genome-Wide Single-Nucleotide Polymorphism Array Analysis Improves Prognostication of Acute Lymphoblastic Leukemia/Lymphoma". J Mol Diagn. 18 (4): 595–603. doi:10.1016/j.jmoldx.2016.03.004. PMID 27161658.
  5. ↑ Goud TM, Al Salmani KK, Al Harasi SM, Al Musalhi M, Wasifuddin SM, Rajab A (2015). "Importance of FISH combined with Morphology, Immunophenotype and Cytogenetic Analysis of Childhood/ Adult Acute Lymphoblastic Leukemia in Omani Patients". Asian Pac. J. Cancer Prev. 16 (16): 7343–50. PMID 26514535.
  6. ↑ Nagayama J, Tomizawa D, Koh K, Nagatoshi Y, Hotta N, Kishimoto T, Takahashi Y, Kuno T, Sugita K, Sato T, Kato K, Ogawa A, Nakahata T, Mizutani S, Horibe K, Ishii E (June 2006). "Infants with acute lymphoblastic leukemia and a germline MLL gene are highly curable with use of chemotherapy alone: results from the Japan Infant Leukemia Study Group". Blood. 107 (12): 4663–5. doi:10.1182/blood-2005-11-4728. PMID 16478880.
  7. ↑ Peter A, Heiden T, Taube T, Körner G, Seeger K (November 2009). "Interphase FISH on TEL/AML1 positive acute lymphoblastic leukemia relapses--analysis of clinical relevance of additional TEL and AML1 copy number changes". Eur. J. Haematol. 83 (5): 420–32. doi:10.1111/j.1600-0609.2009.01315.x. PMID 19594616.
  8. ↑ Greipp PR, Trendle MC, Leong T, Oken MM, Kay NE, Van Ness B, Kyle RA (September 1999). "Is flow cytometric DNA content hypodiploidy prognostic in multiple myeloma?". Leuk. Lymphoma. 35 (1–2): 83–9. doi:10.3109/10428199909145707. PMID 10512165.
  9. ↑ Canaani J, Beohou E, Labopin M, Socié G, Huynh A, Volin L, Cornelissen J, Milpied N, Gedde-Dahl T, Deconinck E, Fegueux N, Blaise D, Mohty M, Nagler A (April 2017). "Impact of FAB classification on predicting outcome in acute myeloid leukemia, not otherwise specified, patients undergoing allogeneic stem cell transplantation in CR1: An analysis of 1690 patients from the acute leukemia working party of EBMT". Am. J. Hematol. 92 (4): 344–350. doi:10.1002/ajh.24640. PMID 28052366.
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