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==Overview==
==Overview==
Myelofibrosis was first discribed by Gustav Heuck, a German surgeon, in 1879, under the title of 'Two cases of leukemia with peculiar blood and bone marrow findings'.<ref name="Tefferi2007">{{cite journal|last1=Tefferi|first1=A|title=The history of myeloproliferative disorders: before and after Dameshek|journal=Leukemia|volume=22|issue=1|year=2007|pages=3–13|issn=0887-6924|doi=10.1038/sj.leu.2404946}}</ref>
The history of myelofibrosis can be divided into pre- and post-Dameshek era. William Dameshek, a Harvard Medical School graduate and a successful clinical hematologist of his time, grouped together chronic myelogenous leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), and erythroleukemia with the reason that a self-perpetuating trilineage myeloproliferation underlined their pathogenesis. He called them 'myeloproliferative disorders'.
The first description of primary myelofibrosis (PMF) is credited to a German surgeon, Gustav Heuck. He described the concept in 1879 under the title of ‘Two cases of leukemia with peculiar blood and bone marrow findings’.<ref name="pmid17882283">{{cite journal |vauthors=Tefferi A |title=The history of myeloproliferative disorders: before and after Dameshek |journal=Leukemia |volume=22 |issue=1 |pages=3–13 |date=January 2008 |pmid=17882283 |doi=10.1038/sj.leu.2404946 |url=}}</ref>


==Historical Perspective==
==Historical Perspective==

Revision as of 00:36, 8 November 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2], Sujit Routray, M.D. [3]

Overview

The history of myelofibrosis can be divided into pre- and post-Dameshek era. William Dameshek, a Harvard Medical School graduate and a successful clinical hematologist of his time, grouped together chronic myelogenous leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), and erythroleukemia with the reason that a self-perpetuating trilineage myeloproliferation underlined their pathogenesis. He called them 'myeloproliferative disorders'. The first description of primary myelofibrosis (PMF) is credited to a German surgeon, Gustav Heuck. He described the concept in 1879 under the title of ‘Two cases of leukemia with peculiar blood and bone marrow findings’.[1]

Historical Perspective

  • Myelofibrosis was first discribed by Gustav Heuck, a German surgeon, in 1879, under the title of 'Two cases of leukemia with peculiar blood and bone marrow findings'.[2]
  • The concept of myeloproliferative disorders (MPDs) was described by William Dameshek, in 1951, by bringing together these five clinicopathologic entities: chronic myelogenous leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), and erythroleukemia.[2]
  • The World Health Organization utilizes the name "chronic idiopathic myelofibrosis", while the International Working Group on Myelofibrosis Research and Treatment calls the disease "primary myelofibrosis".[3]

References

  1. Tefferi A (January 2008). "The history of myeloproliferative disorders: before and after Dameshek". Leukemia. 22 (1): 3–13. doi:10.1038/sj.leu.2404946. PMID 17882283.
  2. 2.0 2.1 Tefferi, A (2007). "The history of myeloproliferative disorders: before and after Dameshek". Leukemia. 22 (1): 3–13. doi:10.1038/sj.leu.2404946. ISSN 0887-6924.
  3. History of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 7, 2016

Catgeory:Oncology


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