Myelofibrosis laboratory tests: Difference between revisions

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Revision as of 18:05, 5 December 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Peripheral blood smear and bone marrow examination helps in making the diagnosis of myelofibrosis. Various tests performed to aid in reaching the diagnosis include complete blood count, peripheral blood smear and bone marrrow examination, complete metabolic panel, and leukocyte alkaline phosphatase test.

Laboratory Tests

Laboratory findings consistent with the diagnosis of myelofibrosis include:^[1]^[2]

Complete Blood Count

Peripheral Blood Smear

Normochromic normocytic anemia
Red cell poikilocytosis on blood film (tear-drop shaped RBCs)
Nucleated red blood cells

Presence of nucleated red blood cells suggests that immature cells are being released into the bloodstream in response to a very high demand for the bone marrow to produce new red blood cells.

Complete Metabolic Panel

Raised levels of lactate dehydrogenase

Leukocyte Alkaline Phosphatase Test (LAP Test)

Raised leukocyte alkaline phosphatase score

References

↑ Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016
↑ Diagnosis of idiopathic myelofibrosis. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/idiopathic-myelofibrosis/?region=on. Accessed on March 9, 2016

Template:WikiDoc Sources

[wikidiagn1osismf1-1] Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016

[cancercaidiopathicmyelofibrosisdx1-2] Diagnosis of idiopathic myelofibrosis. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/idiopathic-myelofibrosis/?region=on. Accessed on March 9, 2016

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[2]

@@ Line 4: / Line 4: @@
 ==Overview==
-Laboratory findings consistent with the diagnosis of myelofibrosis include [[anemia|decreased red blood cells]], [[normochromic]] normocytic [[anemia]], tear-drop shaped RBCs, [[thrombocytopenia]], and raised levels of [[lactate dehydrogenase]].<ref name=wikidiagn1osismf1>Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016</ref><ref name=cancercaidiopathicmyelofibrosisdx1>Diagnosis of idiopathic myelofibrosis. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/idiopathic-myelofibrosis/?region=on. Accessed on March 9, 2016</ref>
+Peripheral blood smear and bone marrow examination helps in making the diagnosis of myelofibrosis. Various tests performed to aid in reaching the diagnosis include complete blood count, peripheral blood smear and bone marrrow examination, complete metabolic panel, and leukocyte alkaline phosphatase test.
 ==Laboratory Tests==