Myeloproliferative neoplasm other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
Other diagnostic studies for myeloproliferative neoplasm include [[bone marrow aspiration]] and [[biopsy|trephine biopsy]], [[lumbar puncture]], and [[lymph node biopsy]]. | Other diagnostic studies for myeloproliferative neoplasm include [[bone marrow aspiration]] and [[biopsy|trephine biopsy]], [[lumbar puncture]], and [[lymph node biopsy]]. | ||
==Other diagnostic studies== | ==Other diagnostic studies== | ||
Other diagnostic studies for myeloproliferative neoplasm include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab</ref><ref>{{cite book |author=Levene, Malcolm I.; Lewis, S. M.; Bain, Barbara J.; Imelda Bates|title=Dacie & Lewis Practical Haematology |publisher=W B Saunders |location=London |year= |pages= |isbn=0-443-06377-X |pages=586}}</ref> | Other diagnostic studies for myeloproliferative neoplasm include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab</ref><ref>{{cite book |author=Levene, Malcolm I.; Lewis, S. M.; Bain, Barbara J.; Imelda Bates|title=Dacie & Lewis Practical Haematology |publisher=W B Saunders |location=London |year= |pages= |isbn=0-443-06377-X |pages=586}}</ref> | ||
*[[Bone marrow aspiration]] and [[biopsy|trephine biopsy]] | *[[Bone marrow aspiration]] and [[biopsy|trephine biopsy]]: This is an invasive diagnostic procedure that is sometimes required for the diagnosis of myeloproliferative neoplasm. Bone marrow biopsy usually shows high proportions of [[leukocytes]], [[erythrocytes]], and [[thrombocytes]]. This is referred to as [[panmyelosis]]. These findings on a bone marrow biopsy constitute one of the major diagnostic criteria for various subtypes of myeloproliferative neoplasm in the 2016 WHO classification.<ref name="pmid27069254">{{cite journal| author=Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM et al.| title=The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. | journal=Blood | year= 2016 | volume= 127 | issue= 20 | pages= 2391-405 | pmid=27069254 | doi=10.1182/blood-2016-03-643544 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27069254 }} </ref> | ||
: | *'''[[Erythropoietin]] level''': [[Erythropoietin]] level is usually low in polycythemia vera. This is because polycythemia vera is characterized by autonomous production of [[red blood cells]] in an erythropoietin-independent manner. | ||
*[[Lumbar puncture]] | *[[Lumbar puncture]] | ||
:*Used to detect any metastasis to the [[cerebral spinal fluid]] (CSF) | :*Used to detect any metastasis to the [[cerebral spinal fluid]] (CSF) | ||
| Line 15: | Line 16: | ||
*[[Arterial oxygen saturation]] | *[[Arterial oxygen saturation]] | ||
==Gallery== | |||
<gallery widths=200px class="center"> | |||
CDR554337-274.jpg| Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.<ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/leukemia/patient/cml-treatment-pdq</ref> | |||
==Gallery== | ==Gallery== | ||
<gallery widths=200px class="center"> | <gallery widths=200px class="center"> | ||
Revision as of 22:31, 23 June 2018
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Myeloproliferative Neoplasm Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Other diagnostic studies for myeloproliferative neoplasm include bone marrow aspiration and trephine biopsy, lumbar puncture, and lymph node biopsy.
Other diagnostic studies
Other diagnostic studies for myeloproliferative neoplasm include:[1][2]
- Bone marrow aspiration and trephine biopsy: This is an invasive diagnostic procedure that is sometimes required for the diagnosis of myeloproliferative neoplasm. Bone marrow biopsy usually shows high proportions of leukocytes, erythrocytes, and thrombocytes. This is referred to as panmyelosis. These findings on a bone marrow biopsy constitute one of the major diagnostic criteria for various subtypes of myeloproliferative neoplasm in the 2016 WHO classification.[3]
- Erythropoietin level: Erythropoietin level is usually low in polycythemia vera. This is because polycythemia vera is characterized by autonomous production of red blood cells in an erythropoietin-independent manner.
- Lumbar puncture
- Used to detect any metastasis to the cerebral spinal fluid (CSF)
- Used to detect and/or determine the type of leukemic cells
Gallery
-
![Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4]](/images/e/e4/CDR554337-274.jpg)
Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4] -
Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4]
![Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4]](/index.php/File:CDR554337-274.jpg)
References
- ↑ Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab
- ↑ Levene, Malcolm I.; Lewis, S. M.; Bain, Barbara J.; Imelda Bates. Dacie & Lewis Practical Haematology. London: W B Saunders. p. 586. ISBN 0-443-06377-X.
- ↑ Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM; et al. (2016). "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): 2391–405. doi:10.1182/blood-2016-03-643544. PMID 27069254.
- ↑ 4.0 4.1 National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/leukemia/patient/cml-treatment-pdq