Oligoastrocytoma other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
Other diagnostic studies for oligoastrocytoma include [[biopsy]] ("''star-shaped''" astrocytes with ovoid nucleus and homogeneous, compact oligodendrocytes with distinct borders, round nucleus, and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “''fried egg''” appearance) and [[fish|fluorescent in-situ hybridization (FISH) technique]] (deletions of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q]]). | Other diagnostic studies for oligoastrocytoma include [[biopsy]] ("''star-shaped''" astrocytes with ovoid nucleus and homogeneous, compact oligodendrocytes with distinct borders, round nucleus, and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “''fried egg''” appearance) and [[fish|fluorescent in-situ hybridization (FISH) technique]] (deletions of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q]]). | ||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Biopsy=== | ===Biopsy=== | ||
*Biopsy may be performed to help confirm the diagnosis of oligoastrocytoma.<ref name=diagOAwiki>Diagnosis of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 20, 2015</ref> | *Biopsy may be performed to help confirm the diagnosis of oligoastrocytoma.<ref name="diagOAwiki">Diagnosis of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 20, 2015</ref> | ||
*On [[biopsy]], oligoastrocytoma is characterized by "''star-shaped''" astrocytes with ovoid nucleus and homogeneous, compact oligodendrocytes with distinct borders, round nucleus, and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “''fried egg''” appearance. | *On [[biopsy]], oligoastrocytoma is characterized by "''star-shaped''" astrocytes with ovoid nucleus and homogeneous, compact oligodendrocytes with distinct borders, round nucleus, and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “''fried egg''” appearance. | ||
*Biopsy may be done at the time of [[surgical resection]] of oligoastrocytoma. | *Biopsy may be done at the time of [[surgical resection]] of oligoastrocytoma. | ||
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===Fluorescent in-situ hybridization (FISH) technique=== | ===Fluorescent in-situ hybridization (FISH) technique=== | ||
*30-70% of oligoastrocytomas show loss of heterozygosity (LOH) of [[chromosome 1|1p]] and [[chromosome 19|19q]].<ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116 }} </ref> | *30-70% of oligoastrocytomas show loss of heterozygosity (LOH) of [[chromosome 1|1p]] and [[chromosome 19|19q]].<ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116 }} </ref> | ||
*[[FISH]] demonstrates deletions of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q]].<ref name=turk>{{Citation | *[[FISH]] demonstrates deletions of [[chromosome 1|chromosome 1p]] and [[chromosome 19|19q]].<ref name="turk">{{Citation |last=Ersen |first=Ayca|year=2008 |title=Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007 |publisher=Turkish Journal of Pathology |publication-place= |page= |url=http://www.turkjpath.org/text.php3?id=645 |accessdate=20 October, 2015 }}</ref><ref name="pmid10653879">{{cite journal| author=Smith JS, Perry A, Borell TJ, Lee HK, O'Fallon J, Hosek SM et al.| title=Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas. | journal=J Clin Oncol | year= 2000 | volume= 18 | issue= 3 | pages= 636-45 | pmid=10653879 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10653879 }} </ref> | ||
==References== | ==References== | ||
Latest revision as of 03:10, 23 October 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Other diagnostic studies for oligoastrocytoma include biopsy ("star-shaped" astrocytes with ovoid nucleus and homogeneous, compact oligodendrocytes with distinct borders, round nucleus, and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “fried egg” appearance) and fluorescent in-situ hybridization (FISH) technique (deletions of chromosome 1p and 19q).
Other Diagnostic Studies
Biopsy
- Biopsy may be performed to help confirm the diagnosis of oligoastrocytoma.[1]
- On biopsy, oligoastrocytoma is characterized by "star-shaped" astrocytes with ovoid nucleus and homogeneous, compact oligodendrocytes with distinct borders, round nucleus, and clear cytoplasm surrounding a dense central nucleus and perinuclear halo, giving it the characteristic “fried egg” appearance.
- Biopsy may be done at the time of surgical resection of oligoastrocytoma.
- Biopsy may be of two types: open and stereotactic.
- Indications for open biopsy and stereotactic biopsy are described below:[2]
| Type of biopsy | Indications |
|---|---|
|
Fluorescent in-situ hybridization (FISH) technique
- 30-70% of oligoastrocytomas show loss of heterozygosity (LOH) of 1p and 19q.[3]
- FISH demonstrates deletions of chromosome 1p and 19q.[4][5]
References
- ↑ Diagnosis of oligoastrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Oligoastrocytoma. Accessed on October 20, 2015
- ↑ Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN (2004). "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion". N Engl J Med. 351 (18): 1875–82. doi:10.1056/NEJMcpc049025. PMID 15509821.
- ↑ Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J; et al. (2002). "Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets". Am J Pathol. 161 (1): 313–9. doi:10.1016/S0002-9440(10)64183-1. PMC 1850690. PMID 12107116.
- ↑ Ersen, Ayca (2008), Pathology of malignant gliomas: Challenges of everyday practice and the WHO 2007, Turkish Journal of Pathology, retrieved 20 October, 2015 Check date values in:
|accessdate=(help) - ↑ Smith JS, Perry A, Borell TJ, Lee HK, O'Fallon J, Hosek SM; et al. (2000). "Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas". J Clin Oncol. 18 (3): 636–45. PMID 10653879.