Splenic marginal zone lymphoma medical therapy: Difference between revisions
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The predominant therapy for splenic marginal zone lymphoma is [[surgery]]. Adjunctive [[radiotherapy]], [[chemotherapy]], and [[biological therapy]] may be required. The optimal therapy for splenic marginal zone lymphoma depends on the clinical presentation. | The predominant therapy for splenic marginal zone lymphoma is [[surgery]]. Adjunctive [[radiotherapy]], [[chemotherapy]], and [[biological therapy]] may be required. The optimal therapy for splenic marginal zone lymphoma depends on the clinical presentation. | ||
==Medical Therapy== | ==Medical Therapy== | ||
The | * The optimal therapy for splenic marginal zone lymphoma depends on the clinical presentation. | ||
* Treatment options for the condition are as under | |||
** Watchful waiting | |||
*** It is a slow growing tumor so patients may not need treatment right away unless symptomatic. Asymptomatic patients may be observed every 3-6 months.<ref name="pmid18094718">{{cite journal |vauthors=Matutes E, Oscier D, Montalban C, Berger F, Callet-Bauchu E, Dogan A, Felman P, Franco V, Iannitto E, Mollejo M, Papadaki T, Remstein ED, Salar A, Solé F, Stamatopoulos K, Thieblemont C, Traverse-Glehen A, Wotherspoon A, Coiffier B, Piris MA |title=Splenic marginal zone lymphoma proposals for a revision of diagnostic, staging and therapeutic criteria |journal=Leukemia |volume=22 |issue=3 |pages=487–95 |date=March 2008 |pmid=18094718 |doi=10.1038/sj.leu.2405068 |url=}}</ref> | |||
** Splenectomy | |||
***Splenectomy is the preferred option in patients with splenomegaly and having localized symptoms. | |||
*** Splenectomy is also preferred in patients with transformation to large B cell lymphoma. | |||
*** | |||
** Radiation therapy | |||
** Chemotherapy | |||
** Biological therapy | |||
** combination therapy | |||
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center | {| style="border: 0px; font-size: 90%; margin: 3px;" align=center | ||
|+ '''Treatment of splenic marginal zone lymphoma<ref name= canadiancancer> Splenic marginal zone lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/splenic-marginal-zone-lymphoma/?region=on Accessed on December 23,2015</ref>''' | |+ '''Treatment of splenic marginal zone lymphoma<ref name= canadiancancer> Splenic marginal zone lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/splenic-marginal-zone-lymphoma/?region=on Accessed on December 23,2015</ref>''' | ||
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| style="padding: 5px 5px; background: #F5F5F5;" | [[Rituximab]] may be used alone or in combination with chemotherapy | | style="padding: 5px 5px; background: #F5F5F5;" | [[Rituximab]] may be used alone or in combination with chemotherapy | ||
|} | |} | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 03:27, 28 December 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
The predominant therapy for splenic marginal zone lymphoma is surgery. Adjunctive radiotherapy, chemotherapy, and biological therapy may be required. The optimal therapy for splenic marginal zone lymphoma depends on the clinical presentation.
Medical Therapy
- The optimal therapy for splenic marginal zone lymphoma depends on the clinical presentation.
- Treatment options for the condition are as under
- Watchful waiting
- It is a slow growing tumor so patients may not need treatment right away unless symptomatic. Asymptomatic patients may be observed every 3-6 months.[1]
- Splenectomy
- Splenectomy is the preferred option in patients with splenomegaly and having localized symptoms.
- Splenectomy is also preferred in patients with transformation to large B cell lymphoma.
- Radiation therapy
- Chemotherapy
- Biological therapy
- combination therapy
- Watchful waiting
| Therapy | Description |
|---|---|
| Watchful waiting | People may not need treatment right away unless they have symptoms |
| Splenectomy | Often respond very well when their spleen is removed with surgery |
| Radiation Therapy | When a splenectomy is not an option, external beam radiation therapy to the spleen |
| Chemotherapy | Doesn’t respond well to chemotherapy
|
| Biological therapy | Rituximab may be used alone or in combination with chemotherapy |
References
- ↑ Matutes E, Oscier D, Montalban C, Berger F, Callet-Bauchu E, Dogan A, Felman P, Franco V, Iannitto E, Mollejo M, Papadaki T, Remstein ED, Salar A, Solé F, Stamatopoulos K, Thieblemont C, Traverse-Glehen A, Wotherspoon A, Coiffier B, Piris MA (March 2008). "Splenic marginal zone lymphoma proposals for a revision of diagnostic, staging and therapeutic criteria". Leukemia. 22 (3): 487–95. doi:10.1038/sj.leu.2405068. PMID 18094718.
- ↑ Splenic marginal zone lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/splenic-marginal-zone-lymphoma/?region=on Accessed on December 23,2015