Tongue cancer causes: Difference between revisions
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Tongue cancer is caused by a point mutation in the [[tumor suppressor gene]] (''[[TP53]]''). The other [[oncogenes]] associated with oral squamous cell cancers of tongue include ''[[c-myc]]'' and ''erb -b1''. | Tongue cancer is caused by a point mutation in the [[tumor suppressor gene]] (''[[TP53]]''). The other [[oncogenes]] associated with oral squamous cell cancers of tongue include ''[[c-myc]]'' and ''erb -b1''. | ||
==Causes== | ==Causes== | ||
*The mutations in [[tumor suppressor genes]] has been reported in patients with cancers of the oral cavity. | The main cause of tongue cancer is genetic mutations due to precancerous lesions or chronic inflammation as follows: | ||
*The most abundant carcinogens in tobacco constitute [[nitrosamines]]. Nitrosamines can damage [[DNA]], leading to point [[mutations]]. These point mutations lead to deregulation of [[tumor suppressor genes]] (''[[TP53]]''), which is located on [[chromosome 17]]. | *The [[Mutation|mutations]] in [[tumor suppressor genes]] has been reported in patients with cancers of the oral cavity. | ||
*The other oncogenes associated with oral squamous cell cancers of tongue include ''[[c-myc]]'' and ''erb -b1''. Tobacco exposure causes progressive sequential histological changes to the oral mucosa. Prolonged period of exposure eventually leads to neoplastic transformation, in particular changes in the expression of ''[[p53]]'' [[mutations]]. | *The most abundant carcinogens in tobacco constitute [[nitrosamines]]. Nitrosamines can damage [[DNA]], leading to point [[mutations]]. | ||
*These point mutations lead to deregulation of [[tumor suppressor genes]] (''[[TP53]]''), which is located on [[chromosome 17]]. | |||
*The other [[oncogenes]] associated with oral [[Squamous cell carcinoma|squamous cell cancers]] of tongue include ''[[c-myc]]'' and ''erb -b1''. | |||
*Tobacco exposure causes progressive sequential histological changes to the oral mucosa. Prolonged period of exposure eventually leads to neoplastic transformation, in particular changes in the expression of ''[[p53]]'' [[mutations]]. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 19:27, 5 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Tongue cancer is caused by a point mutation in the tumor suppressor gene (TP53). The other oncogenes associated with oral squamous cell cancers of tongue include c-myc and erb -b1.
Causes
The main cause of tongue cancer is genetic mutations due to precancerous lesions or chronic inflammation as follows:
- The mutations in tumor suppressor genes has been reported in patients with cancers of the oral cavity.
- The most abundant carcinogens in tobacco constitute nitrosamines. Nitrosamines can damage DNA, leading to point mutations.
- These point mutations lead to deregulation of tumor suppressor genes (TP53), which is located on chromosome 17.
- The other oncogenes associated with oral squamous cell cancers of tongue include c-myc and erb -b1.
- Tobacco exposure causes progressive sequential histological changes to the oral mucosa. Prolonged period of exposure eventually leads to neoplastic transformation, in particular changes in the expression of p53 mutations.