Spontaneous coronary artery dissection causes: Difference between revisions

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==Causes==
==Causes==


The exact etiology of spontaneous coronary artery dissection (SCAD) remains elusive and appears to be multifactorial.  It has been postulated that the phenotypic manifestation of SCAD may occur as a result of predisposing factors compounded by precipitating stressors.<ref name="SawMancini2016">{{cite journal|last1=Saw|first1=Jacqueline|last2=Mancini|first2=G.B. John|last3=Humphries|first3=Karin H.|title=Contemporary Review on Spontaneous Coronary Artery Dissection|journal=Journal of the American College of Cardiology|volume=68|issue=3|year=2016|pages=297–312|issn=07351097|doi=10.1016/j.jacc.2016.05.034}}</ref> Conditions that have been implicated as a potential cause include:
The exact etiology of spontaneous coronary artery dissection (SCAD) remains elusive and appears to be multifactorial.  It has been postulated that the phenotypic manifestation of SCAD may occur as a result of predisposing factors compounded by precipitating stressors.<ref name="SawMancini2016">{{cite journal|last1=Saw|first1=Jacqueline|last2=Mancini|first2=G.B. John|last3=Humphries|first3=Karin H.|title=Contemporary Review on Spontaneous Coronary Artery Dissection|journal=Journal of the American College of Cardiology|volume=68|issue=3|year=2016|pages=297–312|issn=07351097|doi=10.1016/j.jacc.2016.05.034}}</ref>
 
{| class="wikitable" style="font-size: 85%;"
! style="background: #4479BA; text-align: center; width: 150px;" |{{fontcolor|#FFF|Potential Cause}}
! style="background: #4479BA; text-align: center; width: 850px;" colspan=2 | {{fontcolor|#FFF|Condition}}
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" | '''Predisposing factors'''
| style="background: #F5F5F5; padding: 5px;" colspan="2;"|
* [[Fibromuscular dysplasia]]
* [[Takotsubo cardiomyopathy]]
* [[Pregnancy|Pregnancy-related]]: [[antepartum]], [[postpartum|early post-partum]], [[postpartum|late post-partum]], [[postpartum|very late post-partum]]
* [[Pregnancy|Recurrent pregnancies]]: [[Parity (medicine)|multiparity]] or [[multigravida]]
* [[Connective tissue disorder]]: [[Marfan syndrome]], [[Loeys-Dietz syndrome]], [[Ehlers-Danlos syndrome|Ehlers-Danlos syndrome type 4]], [[cystic medial necrosis]], [[alpha-1 antitrypsin deficiency]], [[polycystic kidney disease]]
* [[Systemic inflammation|Systemic inflammatory disease]]: [[systemic lupus erythematosus]], [[Crohn's disease]], [[ulcerative colitis]], [[polyarteritis nodosa]], [[sarcoidosis]], [[Churg-Strauss syndrome]], [[Wegener's granulomatosis]], [[rheumatoid arthritis]], [[Kawasaki disease]], [[giant cell arteritis]], [[celiac disease]]
* [[Hormonal therapy]]: [[oral contraceptive]], [[estrogen]], [[progesterone]], [[beta-HCG]], [[testosterone]], [[corticosteroids]]
* [[Coronary artery spasm]]
* [[Idiopathic]]
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" | '''Precipitating stressors'''
| style="background: #F5F5F5; padding: 5px;" colspan="2;"|
* [[exercise|Intense exercises]]: [[Isometric exercise]], [[aerobic exercise]]
* [[emotional stress|Emotional stress]]
* [[Labor|Labor and delivery]]
* [[Valsalva maneuver|Valsava-type activities]]: [[retching]], [[vomiting]], [[bowel movement]], [[coughing]]
* [[Recreational drugs]]: [[cocaine]], [[amphetamines]], [[methamphetamines]]
* [[Hormonal therapy]]: [[beta-HCG]], [[corticosteroids]]
|}


==References==
==References==

Revision as of 16:36, 29 November 2017

Spontaneous Coronary Artery Dissection Microchapters

Home

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Spontaneous coronary artery dissection from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Approach

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Angiography

CT

MRI

Echocardiography

Other Imaging Findings

Other Diagnostic Studies

Treatment

Treatment Approach

Medical Therapy

Percutaneous Coronary Intervention

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Type 1

Type 2A

Type 2B

Type 3

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nate Michalak, B.A.

Synonyms and keywords: SCAD

Overview

Spontaneous coronary artery dissection may occur as a result of predisposing factors (e.g., vasculopathy, pregnancy, connective tissue disorder, systemic inflammation) compounded by precipitating stressors (e.g., strenuous exercise, emotional stress, recreational drugs).

Causes

The exact etiology of spontaneous coronary artery dissection (SCAD) remains elusive and appears to be multifactorial. It has been postulated that the phenotypic manifestation of SCAD may occur as a result of predisposing factors compounded by precipitating stressors.[1]

References

  1. ↑ Saw, Jacqueline; Mancini, G.B. John; Humphries, Karin H. (2016). "Contemporary Review on Spontaneous Coronary Artery Dissection". Journal of the American College of Cardiology. 68 (3): 297–312. doi:10.1016/j.jacc.2016.05.034. ISSN 0735-1097.
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