Non-alcoholic fatty liver disease: Difference between revisions
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===Prognosis=== | ===Prognosis=== | ||
*Prognosis is generally variable with NAFLD patients | *Prognosis is generally variable with NAFLD patients. | ||
*Depending on the NAFLD Activity Score (NAS) of the NAFLD at the time of diagnosis, the prognosis may vary. | *Depending on the NAFLD Activity Score (NAS) of the NAFLD at the time of diagnosis, the prognosis may vary. | ||
*The presence of fibrosis in NAFLD patients is associated with a particularly poor prognosis.<ref name="urlPathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality - Younossi - 2011 - Hepatology - Wiley Online Library">{{cite web |url=http://onlinelibrary.wiley.com/doi/10.1002/hep.24268/abstract;jsessionid=B90F10C0CB20CCE0E66ACA4796BBB0A4.f04t01?systemMessage=Wiley+Online+Library+will+be+unavailable+on+2nd+Dec+2017+starting+from+0800+EST+%2F+1300+GMT+%2F+21.00+SGT+for+2.5+hours+due+to+urgent+server+maintenance.+Apologies+for+the+inconvenience. |title=Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality - Younossi - 2011 - Hepatology - Wiley Online Library |format= |work= |accessdate=}}</ref> | *The presence of fibrosis in NAFLD patients is associated with a particularly poor prognosis.<ref name="urlPathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality - Younossi - 2011 - Hepatology - Wiley Online Library">{{cite web |url=http://onlinelibrary.wiley.com/doi/10.1002/hep.24268/abstract;jsessionid=B90F10C0CB20CCE0E66ACA4796BBB0A4.f04t01?systemMessage=Wiley+Online+Library+will+be+unavailable+on+2nd+Dec+2017+starting+from+0800+EST+%2F+1300+GMT+%2F+21.00+SGT+for+2.5+hours+due+to+urgent+server+maintenance.+Apologies+for+the+inconvenience. |title=Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality - Younossi - 2011 - Hepatology - Wiley Online Library |format= |work= |accessdate=}}</ref> |
Revision as of 17:40, 1 December 2017
Non-Alcoholic Fatty Liver Disease Microchapters |
Differentiating Non-Alcoholic Fatty Liver Disease from other Diseases |
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Diagnosis |
Treatment |
Case studies |
Non-alcoholic fatty liver disease On the Web |
American Roentgen Ray Society Images of Non-alcoholic fatty liver disease |
Directions to Hospitals Treating Non-alcoholic fatty liver disease |
Risk calculators and risk factors for Non-alcoholic fatty liver disease |
Editor in Chief: Elliot Tapper, M.D., Beth Israel Deaconess Medical Center
For the patient information page on this topic, click here.
Synonyms and keywords: NASH, NAFLD, non alcoholic steatohepatitis
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Non-Alcoholic Fatty Liver Disease from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications, and Prognosis
Natural History
- The symptoms of NAFLD usually develop in the fourth decade of life.
- With the raising concern of obesity and metabolic syndrome NAFLD is becoming the most common liver disease in the world.
- Our understanding of NAFLD natural history is evolving with extensive research and we can classify NAFLD further by prospectively collecting the data with well defined and well designed studies. [1]
- If left untreated, Patients with NAFLD may progress to develop NASH which is a more serious complication.
Complications
- Common complications of NAFLD include: [2]
- NASH
- Cirrhosis
- Gastro intestinal bleeding
- Liver failure
- Liver cancer
Prognosis
- Prognosis is generally variable with NAFLD patients.
- Depending on the NAFLD Activity Score (NAS) of the NAFLD at the time of diagnosis, the prognosis may vary.
- The presence of fibrosis in NAFLD patients is associated with a particularly poor prognosis.[3]
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies
External Links
- NIH page on Nonalcoholic Steatohepatitis
- ↑ Goh GB, McCullough AJ (2016). "Natural History of Nonalcoholic Fatty Liver Disease". Dig. Dis. Sci. 61 (5): 1226–33. doi:10.1007/s10620-016-4095-4. PMID 27003142.
- ↑ "Nonalcoholic Fatty Liver Disease Symptoms, Causes, and More".