Hemochromatosis history and symptoms: Difference between revisions
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:*[[Deafness]]<ref name="Jones_1983">{{cite journal |author=Jones H, Hedley-Whyte E |title=Idiopathic hemochromatosis (IHC): dementia and ataxia as presenting signs |journal=Neurology |volume=33 |issue=11 |pages=1479-83 |year=1983 |pmid=6685241}}</ref> | :*[[Deafness]]<ref name="Jones_1983">{{cite journal |author=Jones H, Hedley-Whyte E |title=Idiopathic hemochromatosis (IHC): dementia and ataxia as presenting signs |journal=Neurology |volume=33 |issue=11 |pages=1479-83 |year=1983 |pmid=6685241}}</ref> | ||
* A darkish color to the skin (see pigmentation, hence its name '''''Diabete bronze''''' when it was first described by [[Armand Trousseau]] in 1865) | * A darkish color to the skin (see pigmentation, hence its name '''''Diabete bronze''''' when it was first described by [[Armand Trousseau]] in 1865) | ||
{| class="wikitable" | |||
!System involved | |||
!Organs | |||
!Symptom | |||
!Signs | |||
!Mechanisum | |||
|- | |||
| rowspan="2" |Nervous system | |||
|PNS | |||
|Parastheisa | |||
Loss of motor control | |||
|Loss of two point discrimination | |||
Hyporeflaxia decreased power | |||
|Axonal sensory motor polyneuropathy | |||
|- | |||
|CNS | |||
|Abnormal gait | |||
Dementia | |||
|Dyskinesias(Parkinsonian syndrome Multiple sclerosis) | |||
Cognitive decline | |||
|Deposition of iron in basal ganglia | |||
|- | |||
| rowspan="4" |Endocrine | |||
|Pituitary gland | |||
|Menstrual abnormality | |||
Loss of libido | |||
Loss of body hair | |||
|Amenorreha | |||
Erictle ddysfuntion | |||
|Deposition of iron in Pituitary gland | |||
|- | |||
|Thyroid gland | |||
|Fatigue | |||
|Signs of hypothyroidsium | |||
|Deposition of iron in Thyroid gland | |||
|- | |||
|Pancreas | |||
|Polyuria polydipsia polyphagia | |||
|Polyuria polydipsia polyphagia | |||
|Deposition of iron in Pancreas | |||
|- | |||
|Adrenal gland | |||
|Fatigue | |||
|Polyuria Hypotension | |||
|Deposition of iron in Adrenal gland | |||
|- | |||
|Dermatological | |||
|Skin | |||
|Cutaneous hyperpigmentation | |||
|Sun exposed affected mostly with tan of melanin grey | |||
Porphyria cutanea tarda | |||
|iron damage skin, melanin hyperactivity responds thus color of melanin | |||
|- | |||
|Joints | |||
| Metacarpophalangeal | |||
Proximal interphalangeal | |||
wrist | |||
knee | |||
|Pain | |||
Stiffness | |||
Arthritis | |||
Joint swelling | |||
|Decreased ROM | |||
Stiffness improve with rest | |||
|Deposition of iron in articular cartilage | |||
Chondrocalcinosis | |||
|- | |||
|Cardiovascular | |||
|Heart | |||
Blood vessels | |||
|Asymptomatic | |||
Heart failure palpitation Hypertension | |||
|Diastolic dysfunction | |||
Arrhythmias | |||
Dilated cardiomyopathy | |||
|Deposition of iron in cardiac tissue and blood vessels | |||
|- | |||
| rowspan="2" |Gastrointestinal | |||
|Liver | |||
|Fatigue | |||
Fatty diarrhea | |||
Itching | |||
Jaundice | |||
Weight loss | |||
|Hepatomegaly | |||
Liver failure(ascites, encephalopathy) | |||
Liver cancer | |||
Splenomegaly | |||
Cutaneous stigmata of chronic liver disease | |||
|Deposition of iron in liver | |||
|- | |||
|Gallbladder | |||
|Right upper abdominal pain | |||
|Tender hepatomegaly | |||
|Multiple blood transfusion leading to hemochromatosis | |||
|} | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} |
Revision as of 16:50, 4 December 2017
Hemochromatosis Microchapters |
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Hemochromatosis history and symptoms On the Web |
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Risk calculators and risk factors for Hemochromatosis history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sunny Kumar MD [2]
Overview
History and Symptoms
Symptoms usually begin in age of 30 years. The involvement of specific organ produces subsequent symptoms.
- Early indications of hemochromatosis are often like those of other diseases and include the following symptoms:
- Fatigue (feeling very tired)
- Weakness
- Weight loss
- Abdominal pain
- Joint pain
- As iron builds up in the body organs, hemochromatosis may also produce the following symptoms:
- Loss of menstrual periods or early menopause
- Loss of sex drive (libido) or impotence
- Loss of body hair
- Shortness of breath
- Infections
- As the disease progresses, hemochromatosis may cause the following more serious problems:
- Arthritis
- Abdominal pain that does not go away
- Severe fatigue (feeling extremely tired and having a lack of energy)
- Heart failure symptoms
- Gray-colored or bronze-colored skin
- Deafness[4]
- A darkish color to the skin (see pigmentation, hence its name Diabete bronze when it was first described by Armand Trousseau in 1865)
System involved | Organs | Symptom | Signs | Mechanisum |
---|---|---|---|---|
Nervous system | PNS | Parastheisa
Loss of motor control |
Loss of two point discrimination
Hyporeflaxia decreased power |
Axonal sensory motor polyneuropathy |
CNS | Abnormal gait
Dementia |
Dyskinesias(Parkinsonian syndrome Multiple sclerosis)
Cognitive decline |
Deposition of iron in basal ganglia | |
Endocrine | Pituitary gland | Menstrual abnormality
Loss of libido Loss of body hair |
Amenorreha
Erictle ddysfuntion |
Deposition of iron in Pituitary gland |
Thyroid gland | Fatigue | Signs of hypothyroidsium | Deposition of iron in Thyroid gland | |
Pancreas | Polyuria polydipsia polyphagia | Polyuria polydipsia polyphagia | Deposition of iron in Pancreas | |
Adrenal gland | Fatigue | Polyuria Hypotension | Deposition of iron in Adrenal gland | |
Dermatological | Skin | Cutaneous hyperpigmentation | Sun exposed affected mostly with tan of melanin grey
Porphyria cutanea tarda |
iron damage skin, melanin hyperactivity responds thus color of melanin |
Joints | Metacarpophalangeal
Proximal interphalangeal wrist knee |
Pain
Stiffness Arthritis Joint swelling |
Decreased ROM
Stiffness improve with rest |
Deposition of iron in articular cartilage
Chondrocalcinosis |
Cardiovascular | Heart
Blood vessels |
Asymptomatic
Heart failure palpitation Hypertension |
Diastolic dysfunction
Arrhythmias Dilated cardiomyopathy |
Deposition of iron in cardiac tissue and blood vessels |
Gastrointestinal | Liver | Fatigue
Fatty diarrhea Itching Jaundice Weight loss |
Hepatomegaly
Liver failure(ascites, encephalopathy) Liver cancer Splenomegaly Cutaneous stigmata of chronic liver disease |
Deposition of iron in liver |
Gallbladder | Right upper abdominal pain | Tender hepatomegaly | Multiple blood transfusion leading to hemochromatosis |
References
- ↑ Iron Overload and Hemochromatosis Centers for Disease Control and Prevention
- ↑ Hemochromatosis National Digestive Diseases Information Clearinghouse, National Institutes of Health, U.S. Department of Health and Human Services
- ↑ Hemochromatosis-Signs and Symptoms Mayo Foundation for Medical Education and Research (MFMER)
- ↑ Jones H, Hedley-Whyte E (1983). "Idiopathic hemochromatosis (IHC): dementia and ataxia as presenting signs". Neurology. 33 (11): 1479–83. PMID 6685241.