Stomach cancer causes: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Stomach cancer}} | {{Stomach cancer}} | ||
{{CMG}}; {{AE}} {{MAD}} | |||
== Overview == | == Overview == | ||
| Line 23: | Line 24: | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Revision as of 16:31, 4 December 2017
|
Stomach cancer Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Stomach cancer causes On the Web |
|
American Roentgen Ray Society Images of Stomach cancer causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]
Overview
Stomach cancer causes
- Causes of stomach cancer depends on type of cancer:
Adenocarcinoma
- Adenocarcinomas are caused by genetic modulations due to chronic inflammation mainly by H. pylori bacteria.
- K-ras mutations oncogenes are found in invasive cancers and intestinal metaplasia.
- Hepatocyte growth factor receptor c-met oncogene is found in intestinal-type gastric cancers.
- Almost 50% of gastric cancers have alterations in genes TP53, TP73, APC, TFF, DCC, LOH, and FHIT.
- Inactivation of p53 in gastric epithelial cells reduce their ability to undergo apoptosis.
Diffuse gastric carcinoma
- Diffuse gastric carcinomas do not have a precancerous lesion. The E-cadherin gene (CDH1) encodes a transmembrane cellular adhesion protein.
- Somatic mutations in the CDH1 gene by hypermethylation, mutation, and loss of heterozygosity are identified in 40 to 83 percent of sporadic diffuse-type gastric cancers.
- Prostate stem cell antigen gene is also involved in regulating gastric epithelial cell proliferation.
- Its cytoplasmic tail interacts with catenins making the adhesion.