Non-alcoholic fatty liver disease differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

NAFLD must be differentiated from other diseases that cause Hepatomegaly, Jaundice, and cirrhosis and ascites.

Differential Diagnosis

CAUSE	CLINICAL FEATURES	LABORATORY TESTS
Auto Immune Hepatitis	More commonly in females	Anti-Nuclear Antibodies,Anti Microsomal Antibodies and Anti Smooth Muscle Anti bodies.
α1-antitrypsin deficiency	Elevated liver enzyme levels	α1-antitrypsin level and liver biopsy
Wilson disease	Neurologic and psychological  features at age 40 years.	ceruloplasmin level and liver biopsy e.t.c.
Hereditary hemochromatosis	Patient presents with Bronze diabetes, arthritis and congestive heart failure.	HFE genetic testing,Ferritin level and liver biopsy with staining for iron .