Alpha 1-antitrypsin deficiency historical perspective: Difference between revisions
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==Historical Perspective== | ==Historical Perspective== | ||
*In 1963, Carl-Bertil Laurell (1919–2001) and Eriksson at the University of Lund, Sweden was the first to discover A1AD at the General Hospital in Malmö, Sweden.<ref name="Laurell_1963">{{cite journal | author = Laurell CB, Eriksson S | title = The electrophoretic alpha 1-globulin pattern of serum in alpha 1-antitrypsin deficiency | journal = Scand J Clin Lab Invest | year = 1963 | volume = 15 | issue = | pages = 132–140 | url= }}</ref><ref name="Sharp_1969">{{cite journal | author = Sharp H, Bridges R, Krivit W, Freier E | title = Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder. | journal = J Lab Clin Med | volume = 73 | issue = 6 | pages = 934-9 | year = 1969 | id = PMID 4182334}}</ref> | *In 1963, Carl-Bertil Laurell (1919–2001) and Eriksson at the University of Lund, Sweden was the first to discover A1AD at the General Hospital in Malmö, Sweden.<ref name="Laurell_1963">{{cite journal | author = Laurell CB, Eriksson S | title = The electrophoretic alpha 1-globulin pattern of serum in alpha 1-antitrypsin deficiency | journal = Scand J Clin Lab Invest | year = 1963 | volume = 15 | issue = | pages = 132–140 | url= }}</ref><ref name="Sharp_1969">{{cite journal | author = Sharp H, Bridges R, Krivit W, Freier E | title = Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder. | journal = J Lab Clin Med | volume = 73 | issue = 6 | pages = 934-9 | year = 1969 | id = PMID 4182334}}</ref> | ||
*Laurell, along with a medical resident, Sten Eriksson, made the discovery after observing the absence of the α<sub>1</sub> band on protein [[electrophoresis]] in five of 1500 samples; three of the five patient samples were found to have developed emphysema at a young age. | *Laurell, along with a medical resident, Sten Eriksson, made the discovery after observing the absence of the α<sub>1</sub> band on protein [[electrophoresis]] in five of 1500 samples; three of the five patient samples were found to have developed [[emphysema]] at a young age. | ||
*In 1964, Gross described the animal model of emphysema caused by intratracheally instilled papain. | *In 1964, Gross described the animal model of [[emphysema]] caused by intratracheally instilled papain. | ||
*In 1967, Fagerhol described associated allelic variation of AAT. | *In 1967, Fagerhol described associated allelic variation of AAT. | ||
*In 1967, Janoff described neutrophil elastase. | *In 1967, Janoff described [[neutrophil]] elastase. | ||
*In 1969, Sharp described association with neonatal cirrhosis. Sharp ''et al'' was the first to discover the association between liver disease and development of A1AD. | *In 1969, Sharp described association with neonatal [[cirrhosis]]. Sharp ''et al'' was the first to discover the association between [[liver]] [[disease]] and development of A1AD. | ||
==References== | ==References== | ||
Revision as of 16:47, 5 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]Cafer Zorkun, M.D., Ph.D. [3]
Overview
Alpha 1-antitrypsin deficiency (A1AD) was discovered in 1963 by Carl-Bertil Laurell (1919–2001) and Eriksson at the University of Lund, Sweden. In 1969, Sharp et al was the first to discover the association between liver disease and development of A1AD.
Historical Perspective
- In 1963, Carl-Bertil Laurell (1919–2001) and Eriksson at the University of Lund, Sweden was the first to discover A1AD at the General Hospital in Malmö, Sweden.[1][2]
- Laurell, along with a medical resident, Sten Eriksson, made the discovery after observing the absence of the α1 band on protein electrophoresis in five of 1500 samples; three of the five patient samples were found to have developed emphysema at a young age.
- In 1964, Gross described the animal model of emphysema caused by intratracheally instilled papain.
- In 1967, Fagerhol described associated allelic variation of AAT.
- In 1967, Janoff described neutrophil elastase.
- In 1969, Sharp described association with neonatal cirrhosis. Sharp et al was the first to discover the association between liver disease and development of A1AD.
References
- ↑ Laurell CB, Eriksson S (1963). "The electrophoretic alpha 1-globulin pattern of serum in alpha 1-antitrypsin deficiency". Scand J Clin Lab Invest. 15: 132&ndash, 140.
- ↑ Sharp H, Bridges R, Krivit W, Freier E (1969). "Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder". J Lab Clin Med. 73 (6): 934–9. PMID 4182334.