Alpha 1-antitrypsin deficiency x ray

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

On chest Xray Alpha1-antitrypsin deficiency (AATD) emphysema presents as a hyperlucent appearance because healthy tissue has been destroyed.Affected regions also are described as oligemic because they lack the normal rich pattern of branching blood vessels.An unusual characteristic in alpha1-antitrypsin deficiency is found in about two thirds of PiZZ patients; the emphysema has a striking basilar distribution.In contrast, cigarette smoking is associated with more severe apical disease.

X Ray

On chest Xray Alpha1-antitrypsin deficiency (AATD) emphysema presents as:

• a hyperlucent appearance because healthy tissue has been destroyed.
• Affected regions also are described as oligemic because they lack the normal rich pattern of branching blood vessels.
• An unusual characteristic in alpha1-antitrypsin deficiency is found in about two thirds of PiZZ patients; the emphysema has a striking basilar distribution.
• In contrast, cigarette smoking is associated with more severe apical disease.

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