Cholangitis natural history, complications and prognosis: Difference between revisions

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* Before 1980, the mortality rate was greater than 50%; in the past thirty years, it has decreased to 10-30%. <ref name="pmid2218831">{{cite journal| author=Thompson JE, Pitt HA, Doty JE, Coleman J, Irving C| title=Broad spectrum penicillin as an adequate therapy for acute cholangitis. | journal=Surg Gynecol Obstet | year= 1990 | volume= 171 | issue= 4 | pages= 275-82 | pmid=2218831 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2218831  }} </ref><ref name="pmid23307004">{{cite journal| author=Kimura Y, Takada T, Strasberg SM, Pitt HA, Gouma DJ, Garden OJ et al.| title=TG13 current terminology, etiology, and epidemiology of acute cholangitis and cholecystitis. | journal=J Hepatobiliary Pancreat Sci | year= 2013 | volume= 20 | issue= 1 | pages= 8-23 | pmid=23307004 | doi=10.1007/s00534-012-0564-0 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23307004  }} </ref><ref name="pmid18769362">{{cite journal| author=Salek J, Livote E, Sideridis K, Bank S| title=Analysis of risk factors predictive of early mortality and urgent ERCP in acute cholangitis. | journal=J Clin Gastroenterol | year= 2009 | volume= 43 | issue= 2 | pages= 171-5 | pmid=18769362 | doi=10.1097/MCG.0b013e318157c62c | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18769362  }} </ref> These differences in mortality can likely be attributed to improvements in early diagnosis and supportive treatment.
* Before 1980, the mortality rate was greater than 50%; in the past thirty years, it has decreased to 10-30%. <ref name="pmid2218831">{{cite journal| author=Thompson JE, Pitt HA, Doty JE, Coleman J, Irving C| title=Broad spectrum penicillin as an adequate therapy for acute cholangitis. | journal=Surg Gynecol Obstet | year= 1990 | volume= 171 | issue= 4 | pages= 275-82 | pmid=2218831 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2218831  }} </ref><ref name="pmid23307004">{{cite journal| author=Kimura Y, Takada T, Strasberg SM, Pitt HA, Gouma DJ, Garden OJ et al.| title=TG13 current terminology, etiology, and epidemiology of acute cholangitis and cholecystitis. | journal=J Hepatobiliary Pancreat Sci | year= 2013 | volume= 20 | issue= 1 | pages= 8-23 | pmid=23307004 | doi=10.1007/s00534-012-0564-0 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23307004  }} </ref><ref name="pmid18769362">{{cite journal| author=Salek J, Livote E, Sideridis K, Bank S| title=Analysis of risk factors predictive of early mortality and urgent ERCP in acute cholangitis. | journal=J Clin Gastroenterol | year= 2009 | volume= 43 | issue= 2 | pages= 171-5 | pmid=18769362 | doi=10.1097/MCG.0b013e318157c62c | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18769362  }} </ref> These differences in mortality can likely be attributed to improvements in early diagnosis and supportive treatment.
* Patients with signs of [[multiple organ failure]] are likely to die unless they undergo early biliary drainage and treatment with systemic [[antibiotics]]. Other causes of death following severe cholangitis include [[heart failure]] and [[pneumonia]].<ref name="pmid2294844">{{cite journal |vauthors=Lai EC, Tam PC, Paterson IA, Ng MM, Fan ST, Choi TK, Wong J |title=Emergency surgery for severe acute cholangitis. The high-risk patients |journal=Ann. Surg. |volume=211 |issue=1 |pages=55–9 |year=1990 |pmid=2294844 |pmc=1357893 |doi= |url=}}</ref><ref name="pmid17252293">{{cite journal |vauthors=Kimura Y, Takada T, Kawarada Y, Nimura Y, Hirata K, Sekimoto M, Yoshida M, Mayumi T, Wada K, Miura F, Yasuda H, Yamashita Y, Nagino M, Hirota M, Tanaka A, Tsuyuguchi T, Strasberg SM, Gadacz TR |title=Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis: Tokyo Guidelines |journal=J Hepatobiliary Pancreat Surg |volume=14 |issue=1 |pages=15–26 |year=2007 |pmid=17252293 |pmc=2784509 |doi=10.1007/s00534-006-1152-y |url=}}</ref><ref name="KiriyamaTakada2013">{{cite journal|last1=Kiriyama|first1=Seiki|last2=Takada|first2=Tadahiro|last3=Strasberg|first3=Steven M.|last4=Solomkin|first4=Joseph S.|last5=Mayumi|first5=Toshihiko|last6=Pitt|first6=Henry A.|last7=Gouma|first7=Dirk J.|last8=Garden|first8=O. James|last9=Büchler|first9=Markus W.|last10=Yokoe|first10=Masamichi|last11=Kimura|first11=Yasutoshi|last12=Tsuyuguchi|first12=Toshio|last13=Itoi|first13=Takao|last14=Yoshida|first14=Masahiro|last15=Miura|first15=Fumihiko|last16=Yamashita|first16=Yuichi|last17=Okamoto|first17=Kohji|last18=Gabata|first18=Toshifumi|last19=Hata|first19=Jiro|last20=Higuchi|first20=Ryota|last21=Windsor|first21=John A.|last22=Bornman|first22=Philippus C.|last23=Fan|first23=Sheung-Tat|last24=Singh|first24=Harijt|last25=de Santibanes|first25=Eduardo|last26=Gomi|first26=Harumi|last27=Kusachi|first27=Shinya|last28=Murata|first28=Atsuhiko|last29=Chen|first29=Xiao-Ping|last30=Jagannath|first30=Palepu|last31=Lee|first31=Sung Gyu|last32=Padbury|first32=Robert|last33=Chen|first33=Miin-Fu|last34=Dervenis|first34=Christos|last35=Chan|first35=Angus C.W.|last36=Supe|first36=Avinash N.|last37=Liau|first37=Kui-Hin|last38=Kim|first38=Myung-Hwan|last39=Kim|first39=Sun-Whe|title=TG13 guidelines for diagnosis and severity grading of acute cholangitis (with videos)|journal=Journal of Hepato-Biliary-Pancreatic Sciences|volume=20|issue=1|year=2013|pages=24–34|issn=18686974|doi=10.1007/s00534-012-0561-3}}</ref>
* Patients with signs of [[multiple organ failure]] are likely to die unless they undergo early biliary drainage and treatment with systemic [[antibiotics]]. Other causes of death following severe cholangitis include [[heart failure]] and [[pneumonia]].<ref name="pmid2294844">{{cite journal |vauthors=Lai EC, Tam PC, Paterson IA, Ng MM, Fan ST, Choi TK, Wong J |title=Emergency surgery for severe acute cholangitis. The high-risk patients |journal=Ann. Surg. |volume=211 |issue=1 |pages=55–9 |year=1990 |pmid=2294844 |pmc=1357893 |doi= |url=}}</ref><ref name="pmid17252293">{{cite journal |vauthors=Kimura Y, Takada T, Kawarada Y, Nimura Y, Hirata K, Sekimoto M, Yoshida M, Mayumi T, Wada K, Miura F, Yasuda H, Yamashita Y, Nagino M, Hirota M, Tanaka A, Tsuyuguchi T, Strasberg SM, Gadacz TR |title=Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis: Tokyo Guidelines |journal=J Hepatobiliary Pancreat Surg |volume=14 |issue=1 |pages=15–26 |year=2007 |pmid=17252293 |pmc=2784509 |doi=10.1007/s00534-006-1152-y |url=}}</ref><ref name="KiriyamaTakada2013">{{cite journal|last1=Kiriyama|first1=Seiki|last2=Takada|first2=Tadahiro|last3=Strasberg|first3=Steven M.|last4=Solomkin|first4=Joseph S.|last5=Mayumi|first5=Toshihiko|last6=Pitt|first6=Henry A.|last7=Gouma|first7=Dirk J.|last8=Garden|first8=O. James|last9=Büchler|first9=Markus W.|last10=Yokoe|first10=Masamichi|last11=Kimura|first11=Yasutoshi|last12=Tsuyuguchi|first12=Toshio|last13=Itoi|first13=Takao|last14=Yoshida|first14=Masahiro|last15=Miura|first15=Fumihiko|last16=Yamashita|first16=Yuichi|last17=Okamoto|first17=Kohji|last18=Gabata|first18=Toshifumi|last19=Hata|first19=Jiro|last20=Higuchi|first20=Ryota|last21=Windsor|first21=John A.|last22=Bornman|first22=Philippus C.|last23=Fan|first23=Sheung-Tat|last24=Singh|first24=Harijt|last25=de Santibanes|first25=Eduardo|last26=Gomi|first26=Harumi|last27=Kusachi|first27=Shinya|last28=Murata|first28=Atsuhiko|last29=Chen|first29=Xiao-Ping|last30=Jagannath|first30=Palepu|last31=Lee|first31=Sung Gyu|last32=Padbury|first32=Robert|last33=Chen|first33=Miin-Fu|last34=Dervenis|first34=Christos|last35=Chan|first35=Angus C.W.|last36=Supe|first36=Avinash N.|last37=Liau|first37=Kui-Hin|last38=Kim|first38=Myung-Hwan|last39=Kim|first39=Sun-Whe|title=TG13 guidelines for diagnosis and severity grading of acute cholangitis (with videos)|journal=Journal of Hepato-Biliary-Pancreatic Sciences|volume=20|issue=1|year=2013|pages=24–34|issn=18686974|doi=10.1007/s00534-012-0561-3}}</ref>
* The prognosis is poor if the following five factors are present:<ref name="KiriyamaTakada2013">{{cite journal|last1=Kiriyama|first1=Seiki|last2=Takada|first2=Tadahiro|last3=Strasberg|first3=Steven M.|last4=Solomkin|first4=Joseph S.|last5=Mayumi|first5=Toshihiko|last6=Pitt|first6=Henry A.|last7=Gouma|first7=Dirk J.|last8=Garden|first8=O. James|last9=Büchler|first9=Markus W.|last10=Yokoe|first10=Masamichi|last11=Kimura|first11=Yasutoshi|last12=Tsuyuguchi|first12=Toshio|last13=Itoi|first13=Takao|last14=Yoshida|first14=Masahiro|last15=Miura|first15=Fumihiko|last16=Yamashita|first16=Yuichi|last17=Okamoto|first17=Kohji|last18=Gabata|first18=Toshifumi|last19=Hata|first19=Jiro|last20=Higuchi|first20=Ryota|last21=Windsor|first21=John A.|last22=Bornman|first22=Philippus C.|last23=Fan|first23=Sheung-Tat|last24=Singh|first24=Harijt|last25=de Santibanes|first25=Eduardo|last26=Gomi|first26=Harumi|last27=Kusachi|first27=Shinya|last28=Murata|first28=Atsuhiko|last29=Chen|first29=Xiao-Ping|last30=Jagannath|first30=Palepu|last31=Lee|first31=Sung Gyu|last32=Padbury|first32=Robert|last33=Chen|first33=Miin-Fu|last34=Dervenis|first34=Christos|last35=Chan|first35=Angus C.W.|last36=Supe|first36=Avinash N.|last37=Liau|first37=Kui-Hin|last38=Kim|first38=Myung-Hwan|last39=Kim|first39=Sun-Whe|title=TG13 guidelines for diagnosis and severity grading of acute cholangitis (with videos)|journal=Journal of Hepato-Biliary-Pancreatic Sciences|volume=20|issue=1|year=2013|pages=24–34|issn=18686974|doi=10.1007/s00534-012-0561-3}}</ref>
*#High [[fever]]
*#Elderly patient


==References==
==References==

Revision as of 16:49, 12 December 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2],Farwa Haideri [3]

Overview

Patients who show early signs of multiple organ failure (renal failure, disseminated intravascular coagulation, alterations in the level of consciousness, and shock) or evidence of acute cholangitis, as well as those who do not respond to conservative treatment, should receive systemic antibiotics and undergo emergent biliary drainage. Unless early and appropriate biliary drainage is performed and systemic antibiotics are administered, death will occur. The prognosis is usually good with treatment but poor without treatment.

Natural History

Acute cholangitis is the result of a bacterial infection that causes partial or complete obstruction of the biliary system. Patients with the disease present with a wide range of severity, from low-grade fever to severe sepsis. Patients usually present with Charcot's triad which is fever, abdominal pain and jaundice. Shock with pus within the biliary tree is indicative of acute suppurative cholangitis. Patients present with Reynold's pentad that comprises sepsis and mental confusion in addition.[1] A history of biliary disease, such as gallstones, previous biliary procedures, or the placement of a biliary stent are factors that are very helpful in understanding the natural history of cholangitis.[2]

Complications

Complications related to cholangitis include:[3][4][5]

The risk of complications increased in subsequent years after gallbladder stones were first discovered, but have been decreasing since. Every year, 6-8% of patients whose symptoms progress from minor to serious undergo cholecystectomy. Fortunately, this percentage has been decreasing yearly.[4][5]

Prognosis

  • Acute cholangitis bears a significant risk of death, with the leading cause being irreversible shock with multiple organ failure (which could have multiple possible complications of severe infections). Modern improvements in diagnosis and treatment have led to a reduction in mortality.
  • Before 1980, the mortality rate was greater than 50%; in the past thirty years, it has decreased to 10-30%. [6][7][8] These differences in mortality can likely be attributed to improvements in early diagnosis and supportive treatment.
  • Patients with signs of multiple organ failure are likely to die unless they undergo early biliary drainage and treatment with systemic antibiotics. Other causes of death following severe cholangitis include heart failure and pneumonia.[3][4][5]
  • The prognosis is poor if the following five factors are present:[5]
    1. High fever
    2. Elderly patient

References

  1. Liu, CL & Fan, ST (2001), Surgical Treatment: Evidence-Based and Problem-Oriented (24 ed.), Munich, Germany: Zuckschwerdt
  2. Miura F, Takada T, Kawarada Y, Nimura Y, Wada K, Hirota M, Nagino M, Tsuyuguchi T, Mayumi T, Yoshida M, Strasberg SM, Pitt HA, Belghiti J, de Santibanes E, Gadacz TR, Gouma DJ, Fan ST, Chen MF, Padbury RT, Bornman PC, Kim SW, Liau KH, Belli G, Dervenis C (2007). "Flowcharts for the diagnosis and treatment of acute cholangitis and cholecystitis: Tokyo Guidelines". J Hepatobiliary Pancreat Surg. 14 (1): 27–34. doi:10.1007/s00534-006-1153-x. PMC 2784508. PMID 17252294.
  3. 3.0 3.1 Lai EC, Tam PC, Paterson IA, Ng MM, Fan ST, Choi TK, Wong J (1990). "Emergency surgery for severe acute cholangitis. The high-risk patients". Ann. Surg. 211 (1): 55–9. PMC 1357893. PMID 2294844.
  4. 4.0 4.1 4.2 Kimura Y, Takada T, Kawarada Y, Nimura Y, Hirata K, Sekimoto M, Yoshida M, Mayumi T, Wada K, Miura F, Yasuda H, Yamashita Y, Nagino M, Hirota M, Tanaka A, Tsuyuguchi T, Strasberg SM, Gadacz TR (2007). "Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis: Tokyo Guidelines". J Hepatobiliary Pancreat Surg. 14 (1): 15–26. doi:10.1007/s00534-006-1152-y. PMC 2784509. PMID 17252293.
  5. 5.0 5.1 5.2 5.3 Kiriyama, Seiki; Takada, Tadahiro; Strasberg, Steven M.; Solomkin, Joseph S.; Mayumi, Toshihiko; Pitt, Henry A.; Gouma, Dirk J.; Garden, O. James; Büchler, Markus W.; Yokoe, Masamichi; Kimura, Yasutoshi; Tsuyuguchi, Toshio; Itoi, Takao; Yoshida, Masahiro; Miura, Fumihiko; Yamashita, Yuichi; Okamoto, Kohji; Gabata, Toshifumi; Hata, Jiro; Higuchi, Ryota; Windsor, John A.; Bornman, Philippus C.; Fan, Sheung-Tat; Singh, Harijt; de Santibanes, Eduardo; Gomi, Harumi; Kusachi, Shinya; Murata, Atsuhiko; Chen, Xiao-Ping; Jagannath, Palepu; Lee, Sung Gyu; Padbury, Robert; Chen, Miin-Fu; Dervenis, Christos; Chan, Angus C.W.; Supe, Avinash N.; Liau, Kui-Hin; Kim, Myung-Hwan; Kim, Sun-Whe (2013). "TG13 guidelines for diagnosis and severity grading of acute cholangitis (with videos)". Journal of Hepato-Biliary-Pancreatic Sciences. 20 (1): 24–34. doi:10.1007/s00534-012-0561-3. ISSN 1868-6974.
  6. Thompson JE, Pitt HA, Doty JE, Coleman J, Irving C (1990). "Broad spectrum penicillin as an adequate therapy for acute cholangitis". Surg Gynecol Obstet. 171 (4): 275–82. PMID 2218831.
  7. Kimura Y, Takada T, Strasberg SM, Pitt HA, Gouma DJ, Garden OJ; et al. (2013). "TG13 current terminology, etiology, and epidemiology of acute cholangitis and cholecystitis". J Hepatobiliary Pancreat Sci. 20 (1): 8–23. doi:10.1007/s00534-012-0564-0. PMID 23307004.
  8. Salek J, Livote E, Sideridis K, Bank S (2009). "Analysis of risk factors predictive of early mortality and urgent ERCP in acute cholangitis". J Clin Gastroenterol. 43 (2): 171–5. doi:10.1097/MCG.0b013e318157c62c. PMID 18769362.


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