MMEL1: Difference between revisions

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{{Underlinked|date=April 2014}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Membrane metallo-endopeptidase-like 1''' is a [[protein]] that in humans is encoded by the MMEL1 [[gene]].<ref name="entrez">
{{cite web | title = Entrez Gene: Membrane metallo-endopeptidase-like 1 | url = https://www.ncbi.nlm.nih.gov/gene/79258 }}</ref>


'''Membrane metallo-endopeptidase-like 1''' is a [[protein]] that in humans is encoded by the MMEL1 [[gene]].
== Function ==
<ref name="entrez">
{{cite web
| title = Entrez Gene: Membrane metallo-endopeptidase-like 1
| url = https://www.ncbi.nlm.nih.gov/gene/79258
| accessdate = 2013-07-15 <!-- T12:03:42.366287-08:00 -->
}}</ref>


==Function==
The protein encoded by this gene is a member of the [[neutral endopeptidase]] (NEP) or [[membrane metallo-endopeptidase]] (MME) family. Family members play important roles in pain perception, [[arterial pressure]] regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in [[testis]] with weak expression in the brain, kidney, and heart.
 
The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or [[membrane metallo-endopeptidase]] (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq, Jul 2008].


== References ==
== References ==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{Cite journal  
* {{cite journal | vauthors = Whyteside AR, Turner AJ | title = Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences | journal = FEBS Letters | volume = 582 | issue = 16 | pages = 2382–6 | date = July 2008 | pmid = 18539150 | pmc = | doi = 10.1016/j.febslet.2008.05.046 }}
| last1 = Whyteside | first1 = A. R.
* {{cite journal | vauthors = Danoy P, Wei M, Johanna H, Jiang L, He D, Sun L, Zeng X, Visscher PM, Brown MA, Xu H | title = Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese population | journal = Annals of the Rheumatic Diseases | volume = 70 | issue = 10 | pages = 1793–7 | date = October 2011 | pmid = 21784728 | pmc = | doi = 10.1136/ard.2010.144576 }}
| last2 = Turner | first2 = A. J.
* {{cite journal | vauthors = Natunen T, Helisalmi S, Vepsäläinen S, Sarajärvi T, Antikainen L, Mäkinen P, Herukka SK, Koivisto AM, Haapasalo A, Soininen H, Hiltunen M | title = Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease | journal = Journal of Alzheimer's Disease | volume = 28 | issue = 3 | pages = 553–9 | year = 2012 | pmid = 22027013 | pmc = | doi = 10.3233/JAD-2011-111109 }}
| doi = 10.1016/j.febslet.2008.05.046
* {{cite journal | vauthors = Hirschfield GM, Liu X, Han Y, Gorlov IP, Lu Y, Xu C, Lu Y, Chen W, Juran BD, Coltescu C, Mason AL, Milkiewicz P, Myers RP, Odin JA, Luketic VA, Speiciene D, Vincent C, Levy C, Gregersen PK, Zhang J, Heathcote EJ, Lazaridis KN, Amos CI, Siminovitch KA | title = Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis | journal = Nature Genetics | volume = 42 | issue = 8 | pages = 655–7 | date = August 2010 | pmid = 20639879 | pmc = 2929126 | doi = 10.1038/ng.631 }}
| title = Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences  
* {{cite journal | vauthors = Carpentier M, Guillemette C, Bailey JL, Boileau G, Jeannotte L, DesGroseillers L, Charron J | title = Reduced fertility in male mice deficient in the zinc metallopeptidase NL1 | journal = Molecular and Cellular Biology | volume = 24 | issue = 10 | pages = 4428–37 | date = May 2004 | pmid = 15121861 | pmc = 400486 | doi = 10.1128/MCB.24.10.4428-4437.2004 }}
| journal = FEBS Letters  
* {{cite journal | vauthors = Huang JY, Hafez DM, James BD, Bennett DA, Marr RA | title = Altered NEP2 expression and activity in mild cognitive impairment and Alzheimer's disease | journal = Journal of Alzheimer's Disease | volume = 28 | issue = 2 | pages = 433–41 | year = 2012 | pmid = 22008264 | pmc = 3320721 | doi = 10.3233/JAD-2011-111307 }}
| volume = 582  
* {{cite journal | vauthors = Hu Z, Xia Y, Guo X, Dai J, Li H, Hu H, Jiang Y, Lu F, Wu Y, Yang X, Li H, Yao B, Lu C, Xiong C, Li Z, Gui Y, Liu J, Zhou Z, Shen H, Wang X, Sha J | title = A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia | journal = Nature Genetics | volume = 44 | issue = 2 | pages = 183–6 | date = December 2011 | pmid = 22197933 | pmc = | doi = 10.1038/ng.1040 }}
| issue = 16  
| pages = 2382–2386
| year = 2008  
| pmid = 18539150  
| pmc =  
}}
*{{Cite journal  
| last1 = Danoy | first1 = P.
| last2 = Wei | first2 = M.
| last3 = Johanna | first3 = H.
| last4 = Jiang | first4 = L.
| last5 = He | first5 = D.
| last6 = Sun | first6 = L.
| last7 = Zeng | first7 = X.
| last8 = Visscher | first8 = P. M.
| last9 = Brown | first9 = M. A.
| doi = 10.1136/ard.2010.144576
| last10 = Xu | first10 = H.
| title = Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese population  
| journal = Annals of the Rheumatic Diseases  
| volume = 70  
| issue = 10  
| pages = 1793–1797
| year = 2011  
| pmid = 21784728  
| pmc =  
}}
*{{Cite journal
| last1 = Wieczorek | first1 = S.
| last2 = Holle | first2 = J. U.
| last3 = Müller | first3 = S.
| last4 = Fricke | first4 = H.
| last5 = Gross | first5 = W. L.
| last6 = Epplen | first6 = J. R. T.
| doi = 10.1007/s00109-009-0580-y
| title = A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis
| journal = Journal of Molecular Medicine
| volume = 88
| issue = 4
| pages = 413–421
| year = 2010  
| pmid = 20049410
| pmc =
}}
*{{Cite journal  
| last1 = Natunen | first1 = T.
| last2 = Helisalmi | first2 = S.
| last3 = Vepsäläinen | first3 = S.
| last4 = Sarajärvi | first4 = T.
| last5 = Antikainen | first5 = L.
| last6 = Mäkinen | first6 = P.
| last7 = Herukka | first7 = S. K.
| last8 = Koivisto | first8 = A. M.
| last9 = Haapasalo | first9 = A.
| last10 = Soininen | first10 = H.
| last11 = Hiltunen | first11 = M.
| title = Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease  
| journal = Journal of Alzheimer's disease : JAD
| volume = 28  
| issue = 3  
| pages = 553–559
| year = 2012  
| doi = 10.3233/JAD-2011-111109
| pmid = 22027013  
| pmc =  
}}
*{{Cite journal
| last1 = Anderson | first1 = C. A.
| last2 = Boucher | first2 = G.
| last3 = Lees | first3 = C. W.
| last4 = Franke | first4 = A.
| last5 = d'Amato | first5 = M.
| last6 = Taylor | first6 = K. D.
| last7 = Lee | first7 = J. C.
| last8 = Goyette | first8 = P.
| last9 = Imielinski | first9 = M.
| last10 = Latiano
| doi = 10.1038/ng.764 | first10 = A.
| last11 = Lagacé | first11 = C.
| last12 = Scott | first12 = R.
| last13 = Amininejad | first13 = L.
| last14 = Bumpstead | first14 = S.
| last15 = Baidoo | first15 = L.
| last16 = Baldassano | first16 = R. N.
| last17 = Barclay | first17 = M.
| last18 = Bayless | first18 = T. M.
| last19 = Brand | first19 = S.
| last20 = Büning | first20 = C.
| last21 = Colombel | first21 = J. F. D. R.
| last22 = Denson | first22 = L. A.
| last23 = De Vos | first23 = M.
| last24 = Dubinsky | first24 = M.
| last25 = Edwards | first25 = C.
| last26 = Ellinghaus | first26 = D.
| last27 = Fehrmann | first27 = R. S. N.
| last28 = Floyd | first28 = J. A. B.
| last29 = Florin | first29 = T.
| last30 = Franchimont | first30 = D.
| title = Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
| journal = Nature Genetics
| volume = 43
| issue = 3
| pages = 246–252
| year = 2011  
| pmid = 21297633
| pmc =3084597
}}
*{{Cite journal  
| last1 = Hirschfield | first1 = G. M.
| last2 = Liu | first2 = X.
| last3 = Han | first3 = Y.
| last4 = Gorlov | first4 = I. P.
| last5 = Lu | first5 = Y.
| last6 = Xu | first6 = C.
| last7 = Lu | first7 = Y.
| last8 = Chen | first8 = W.
| last9 = Juran | first9 = B. D.
| last10 = Coltescu  
| doi = 10.1038/ng.631 | first10 = C.
| last11 = Mason | first11 = A. L.
| last12 = Milkiewicz | first12 = P.
| last13 = Myers | first13 = R. P.
| last14 = Odin | first14 = J. A.
| last15 = Luketic | first15 = V. A.
| last16 = Speiciene | first16 = D.
| last17 = Vincent | first17 = C.
| last18 = Levy | first18 = C.
| last19 = Gregersen | first19 = P. K.
| last20 = Zhang | first20 = J.
| last21 = Heathcote | first21 = E. J.
| last22 = Lazaridis | first22 = K. N.
| last23 = Amos | first23 = C. I.
| last24 = Siminovitch | first24 = K. A.
| title = Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis  
| journal = Nature Genetics  
| volume = 42  
| issue = 8  
| pages = 655–657
| year = 2010  
| pmid = 20639879  
| pmc =2929126  
}}
*{{Cite journal  
| last1 = Carpentier | first1 = M.
| last2 = Guillemette | first2 = C.
| last3 = Bailey | first3 = J. L.
| last4 = Boileau | first4 = G.
| last5 = Jeannotte | first5 = L.
| last6 = Desgroseillers | first6 = L.
| last7 = Charron | first7 = J.
| title = Reduced fertility in male mice deficient in the zinc metallopeptidase NL1  
| journal = Molecular and Cellular Biology  
| volume = 24  
| issue = 10  
| pages = 4428–4437
| year = 2004  
| pmid = 15121861  
| pmc = 400486  
| doi = 10.1128/MCB.24.10.4428-4437.2004
}}
*{{Cite journal  
| last1 = Huang | first1 = J. Y.
| last2 = Hafez | first2 = D. M.
| last3 = James | first3 = B. D.
| last4 = Bennett | first4 = D. A.
| last5 = Marr | first5 = R. A.
| title = Altered NEP2 expression and activity in mild cognitive impairment and Alzheimer's disease  
| journal = Journal of Alzheimer's disease : JAD
| volume = 28  
| issue = 2  
| pages = 433–441
| doi = 10.3233/JAD-2011-111307  
| year = 2012
| pmid = 22008264
| pmc =3320721
}}
*{{Cite journal  
| last1 = Hu | first1 = Z.
| last2 = Xia | first2 = Y.
| last3 = Guo | first3 = X.
| last4 = Dai | first4 = J.
| last5 = Li | first5 = H.
| last6 = Hu | first6 = H.
| last7 = Jiang | first7 = Y.
| last8 = Lu | first8 = F.
| last9 = Wu | first9 = Y.
| last10 = Yang  
| doi = 10.1038/ng.1040 | first10 = X.
| last11 = Li | first11 = H.
| last12 = Yao | first12 = B.
| last13 = Lu | first13 = C.
| last14 = Xiong | first14 = C.
| last15 = Li | first15 = Z.
| last16 = Gui | first16 = Y.
| last17 = Liu | first17 = J.
| last18 = Zhou | first18 = Z.
| last19 = Shen | first19 = H.
| last20 = Wang | first20 = X.
| last21 = Sha | first21 = J.
| title = A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia  
| journal = Nature Genetics  
| volume = 44  
| issue = 2  
| pages = 183–186
| year = 2011  
| pmid = 22197933  
| pmc =  
}}
 
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}


{{gene-1-stub}}
{{gene-1-stub}}

Latest revision as of 11:28, 3 March 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Membrane metallo-endopeptidase-like 1 is a protein that in humans is encoded by the MMEL1 gene.[1]

Function

The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.

References

  1. ↑ "Entrez Gene: Membrane metallo-endopeptidase-like 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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