Chromosome 1 open reading frame 162: Difference between revisions

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== Gene ==
== Gene ==
The [[gene]] is located at p13.2 on chromosome 1 in [[humans]] and contains 8 exons.<ref>{{cite web|title=NCBI GenBank|url=https://www.ncbi.nlm.nih.gov/nuccore/KJ895447.1}}</ref> It is 11,026 bases long and is oriented on the plus strand.<ref>{{cite web|title=GeneCards|url=http://www.genecards.org/cgi-bin/carddisp.pl?gene=C1orf162}}</ref>  
The [[gene]] is located at p13.2 on chromosome 1 in [[humans]] and contains 8 exons.<ref>{{cite web|title=NCBI GenBank|url=https://www.ncbi.nlm.nih.gov/nuccore/KJ895447.1}}</ref> It is 11,026 bases long and is oriented on the plus strand.<ref>{{cite web|title=GeneCards|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=C1orf162}}</ref>  


[[File:Genomic context.png|framed|Illustration of genomic context of C1orf162. ]]
[[File:Genomic context.png|framed|Illustration of genomic context of C1orf162. ]]
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==Protein==
==Protein==
The predicted [[molecular weight]] of the protein C1orf162 is 16.9 kdal. Its [[isoelectric point]] is approximately 9.2 in mammals.<ref>{{cite web|title=SDSC Biology Workbench |url=http://seqtool.sdsc.edu/CGI/BW.cgi#!] }}{{dead link|date=November 2016 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> A single transmembrane region is conserved across species.<ref>{{cite web|title=CCTOP|url=http://cctop.enzim.ttk.mta.hu/?_=/jobs/result/1ffcde2bac5705f02c92d18a41d91b03}}</ref> The protein is predicted to localize mainly in the nucleus.<ref>{{cite web|title=PSORTII|url=http://psort.hgc.jp/form2.html}}</ref> The protein is predicted to be myristoylated.<ref>{{cite web|title=Myristoylator Prediction Program|url=http://web.expasy.org/cgi-bin/myristoylator/myristoylator.pl}}</ref>  
The predicted [[molecular weight]] of the protein C1orf162 is 16.9 kdal. Its [[isoelectric point]] is approximately 9.2 in mammals.<ref>{{cite web|title=SDSC Biology Workbench |url=http://seqtool.sdsc.edu/CGI/BW.cgi#!] }}{{dead link|date=November 2016 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> A single transmembrane region is conserved across species.<ref>{{cite web|title=CCTOP|url=http://cctop.enzim.ttk.mta.hu/?_=/jobs/result/1ffcde2bac5705f02c92d18a41d91b03}}</ref> The protein is predicted to localize mainly in the nucleus.<ref>{{cite web|title=PSORTII|url=http://psort.hgc.jp/form2.html}}</ref> The protein is predicted to be myristoylated.<ref>{{cite web|title=Myristoylator Prediction Program|url=http://web.expasy.org/cgi-bin/myristoylator/myristoylator.pl}}{{Dead link|date=November 2018 |bot=InternetArchiveBot |fix-attempted=yes }}</ref>  


[[File:CCTOP prediction.png|framed|Illustration of transmembrane region of C1orf162. ]]
[[File:CCTOP prediction.png|framed|Illustration of transmembrane region of C1orf162. ]]

Latest revision as of 05:42, 23 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Chromosome 1 open reading frame 162 is a protein that in humans is encoded by the C1orf162 gene. It has been found to be hypomethylated in instances of gastric cancer. [1]

Gene

The gene is located at p13.2 on chromosome 1 in humans and contains 8 exons.[2] It is 11,026 bases long and is oriented on the plus strand.[3]

File:Genomic context.png
Illustration of genomic context of C1orf162.

mRNA

Three transcript variants have been identified. Isoform 1 is the longest transcript and encodes the longest isoform. Isoform 2 uses an alternate in-frame splice site and is shorter than isoform 1. Isoform 3 lacks an alternate in-frame exon and is shorter compared to isoform 1.[4] There are six stem loops in the 5' untranslated region and five stem loops in the 3' untranslated region.[5]

Protein

The predicted molecular weight of the protein C1orf162 is 16.9 kdal. Its isoelectric point is approximately 9.2 in mammals.[6] A single transmembrane region is conserved across species.[7] The protein is predicted to localize mainly in the nucleus.[8] The protein is predicted to be myristoylated.[9]

File:CCTOP prediction.png
Illustration of transmembrane region of C1orf162.

Expression

C1orf162 is not ubiquitously expressed in humans. According to microarray-assessed tissue expression patterns, C1orf162 is most highly expressed in bone marrow, lung, fetal liver, lymph node, spleen, and thymus in normal human tissues.[10] Staining of normal tissues has found high levels of RNA expression in bone marrow, lymph node, spleen, and lung tissue, which coincides with microarray-assessed expression patterns.[11]

File:NCBI GEO data.png
Expression of C1orf162 in normal human tissues.

Clinical Significance

One study found the protein to be one of three hypomethylated proteins in instances of gastric cancer. [12]

Homology

The gene has no known paralogs. Orthologs have been noted in many mammal species in addition to a few birds and reptiles. The transmembrane region of the protein is highly conserved across species. No orthologs have been identified in fish, insects, or prokaryotes.[13]


References

  1. ↑ "Entrez Gene: Chromosome 1 open reading frame 162". Retrieved 2016-05-09.
  2. ↑ "NCBI GenBank".
  3. ↑ "GeneCards".
  4. ↑ "NCBI Gene".
  5. ↑ "M-fold Analysis".
  6. ↑ "SDSC Biology Workbench".[permanent dead link]
  7. ↑ "CCTOP".
  8. ↑ "PSORTII".
  9. ↑ "Myristoylator Prediction Program".[permanent dead link]
  10. ↑ "NCBI GEO".
  11. ↑ "Protein Atlas".
  12. ↑ Choi, B. (2013). "Gene methylation as a novel marker in gastric cancer". Cancer Research. 8 (73): 643.
  13. ↑ "NCBI Gene Orthologs".

Further reading


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