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{{Underlinked|date=February 2017}}{{Infobox gene}}
{{Infobox gene}}
'''Major facilitator superfamily domain containing 1''' (MFSD1, SMAP) is a [[protein]] belonging to the MFS Pfam clan.<ref>{{cite journal | vauthors = Perland E, Fredriksson R | title = Classification Systems of Secondary Active Transporters | journal = Trends in Pharmacological Sciences | volume = 38 | issue = 3 | pages = 305–315 | date = March 2017 | pmid = 27939446 | doi = 10.1016/j.tips.2016.11.008 }}</ref> It is an Atypical [[Solute carrier family|solute carrier]].<ref name=":0">{{cite journal | vauthors = Perland E, Hellsten SV, Lekholm E, Eriksson MM, Arapi V, Fredriksson R | title = The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake | journal = Journal of Molecular Neuroscience | volume = 61 | issue = 2 | pages = 199–214 | date = February 2017 | pmid = 27981419 | doi = 10.1007/s12031-016-0867-8 }}</ref>


'''[[Major facilitator superfamily]] domain containing 1''' (MFSD1, SMAP) is a [[protein]] belonging to the MFS Pfam clan.<ref>{{Cite journal|last=Perland|first=Emelie|last2=Fredriksson|first2=Robert|date=2016-12-08|title=Classification Systems of Secondary Active Transporters|journal=Trends in Pharmacological Sciences|doi=10.1016/j.tips.2016.11.008|issn=1873-3735|pmid=27939446|volume=38|pages=305–315}}</ref> It is an Atypical [[Solute carrier family|solute carrier]].<ref name=":0">{{Cite journal|last=Perland|first=Emelie|last2=Hellsten|first2=Sofie V.|last3=Lekholm|first3=Emilia|last4=Eriksson|first4=Mikaela M.|last5=Arapi|first5=Vasiliki|last6=Fredriksson|first6=Robert|date=2016-12-16|title=The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake|journal=Journal of molecular neuroscience: MN|doi=10.1007/s12031-016-0867-8|issn=1559-1166|pmid=27981419}}</ref>
It belongs to the [[major facilitator superfamily]] MFS [[Pfam]] Clan. MFSD1 has been identified in neuronal plasma membranes <ref name=":0" /> and lysosomes.<ref>{{cite journal | vauthors = Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B, Journet A | title = An extended proteome map of the lysosomal membrane reveals novel potential transporters | journal = Molecular & Cellular Proteomics | volume = 12 | issue = 6 | pages = 1572–88 | date = June 2013 | pmid = 23436907 | pmc = 3675815 | doi = 10.1074/mcp.M112.021980 }}</ref><ref>{{cite journal | vauthors = Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A | title = Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways | journal = Human Molecular Genetics | volume = 20 | issue = 19 | pages = 3852–66 | date = October 2011 | pmid = 21752829 | doi = 10.1093/hmg/ddr306 }}</ref>
 
It belongs to the MFS [[Pfam]] Clan. MFSD1 has been identified in neuronal plasma membranes <ref name=":0" /> and lysosomes.<ref>{{Cite journal|last=Chapel|first=Agnès|last2=Kieffer-Jaquinod|first2=Sylvie|last3=Sagné|first3=Corinne|last4=Verdon|first4=Quentin|last5=Ivaldi|first5=Corinne|last6=Mellal|first6=Mourad|last7=Thirion|first7=Jaqueline|last8=Jadot|first8=Michel|last9=Bruley|first9=Christophe|date=June 2013|title=An extended proteome map of the lysosomal membrane reveals novel potential transporters|journal=Molecular & cellular proteomics: MCP|volume=12|issue=6|pages=1572–1588|doi=10.1074/mcp.M112.021980|issn=1535-9484|pmc=3675815|pmid=23436907}}</ref><ref>{{Cite journal|last=Palmieri|first=Michela|last2=Impey|first2=Soren|last3=Kang|first3=Hyojin|last4=di Ronza|first4=Alberto|last5=Pelz|first5=Carl|last6=Sardiello|first6=Marco|last7=Ballabio|first7=Andrea|date=2011-10-01|title=Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways|journal=Human Molecular Genetics|volume=20|issue=19|pages=3852–3866|doi=10.1093/hmg/ddr306|issn=1460-2083|pmid=21752829}}</ref>


[[HUGO Gene Nomenclature Committee|HGNC]]:25874
[[HUGO Gene Nomenclature Committee|HGNC]]:25874


MFSD1 belongs to [[Atypical MFS Transporter Family|AMTF]]6 <ref>{{Cite journal|last=Perland|first=Emelie|last2=Bagchi|first2=Sonchita|last3=Klaesson|first3=Axel|last4=Fredriksson|first4=Robert|date=2017-09-01|title=Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression|url=http://rsob.royalsocietypublishing.org/content/7/9/170142|journal=Open Biology|language=en|volume=7|issue=9|pages=170142|doi=10.1098/rsob.170142|issn=2046-2441}}</ref>
MFSD1 belongs to [[Atypical MFS Transporter Family|AMTF]]6.<ref>{{cite journal | vauthors = Perland E, Bagchi S, Klaesson A, Fredriksson R | title = Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression | language = en | journal = Open Biology | volume = 7 | issue = 9 | pages = 170142 | date = September 2017 | pmid = 28878041 | doi = 10.1098/rsob.170142 }}</ref>


== References ==
== References ==

Latest revision as of 11:18, 20 January 2018

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Major facilitator superfamily domain containing 1 (MFSD1, SMAP) is a protein belonging to the MFS Pfam clan.[1] It is an Atypical solute carrier.[2]

It belongs to the major facilitator superfamily MFS Pfam Clan. MFSD1 has been identified in neuronal plasma membranes [2] and lysosomes.[3][4]

HGNC:25874

MFSD1 belongs to AMTF6.[5]

References

  1. ↑ Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
  2. ↑ 2.0 2.1 Perland E, Hellsten SV, Lekholm E, Eriksson MM, Arapi V, Fredriksson R (February 2017). "The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake". Journal of Molecular Neuroscience. 61 (2): 199–214. doi:10.1007/s12031-016-0867-8. PMID 27981419.
  3. ↑ Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B, Journet A (June 2013). "An extended proteome map of the lysosomal membrane reveals novel potential transporters". Molecular & Cellular Proteomics. 12 (6): 1572–88. doi:10.1074/mcp.M112.021980. PMC 3675815. PMID 23436907.
  4. ↑ Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A (October 2011). "Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways". Human Molecular Genetics. 20 (19): 3852–66. doi:10.1093/hmg/ddr306. PMID 21752829.
  5. ↑ Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMID 28878041.
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