ADH5: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Alcohol dehydrogenase class-3''' is an [[enzyme]] that in humans is encoded by the ''ADH5'' [[gene]].<ref name="pmid1446828">{{cite journal | vauthors = Hur MW, Edenberg HJ | title = Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase | journal = Gene | volume = 121 | issue = 2 | pages = 305–11 |date=Dec 1992| pmid = 1446828 | pmc =  | doi =10.1016/0378-1119(92)90135-C  }}</ref><ref name="pmid6424546">{{cite journal | vauthors = Adinolfi A, Adinolfi M, Hopkinson DA | title = Immunological and biochemical characterization of the human alcohol dehydrogenase chi-ADH isozyme | journal = Ann Hum Genet | volume = 48 | issue = Pt 1 | pages = 1–10 |date=May 1984| pmid = 6424546 | pmc =  | doi =10.1111/j.1469-1809.1984.tb00828.x  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=128| accessdate = }}</ref>
'''Alcohol dehydrogenase class-3''' is an [[enzyme]] that in [[human]]s is encoded by the ''ADH5'' [[gene]].<ref name="pmid1446828">{{cite journal | vauthors = Hur MW, Edenberg HJ | title = Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase | journal = Gene | volume = 121 | issue = 2 | pages = 305–11 |date=Dec 1992| pmid = 1446828 | pmc =  | doi =10.1016/0378-1119(92)90135-C  }}</ref><ref name="pmid6424546">{{cite journal | vauthors = Adinolfi A, Adinolfi M, Hopkinson DA | title = Immunological and biochemical characterization of the human alcohol dehydrogenase chi-ADH isozyme | journal = Ann Hum Genet | volume = 48 | issue = Pt 1 | pages = 1–10 |date=May 1984| pmid = 6424546 | pmc =  | doi =10.1111/j.1469-1809.1984.tb00828.x  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=128| accessdate = }}</ref>


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| summary_text = This gene encodes glutathione-dependent formaldehyde dehydrogenase or class III alcohol dehydrogenase chi subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class III alcohol dehydrogenase is a homodimer composed of 2 chi subunits. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis.<ref name="entrez"/>
| summary_text = This gene encodes [[glutathione]]-dependent [[formaldehyde dehydrogenase]] or the class III [[alcohol dehydrogenase]] chi subunit, which is a member of the [[alcohol]] dehydrogenase family. Members of this family [[metabolism|metabolize]] a wide variety of [[Substrate (chemistry)|substrates]], including [[ethanol]], [[retinol]], other [[Aliphatic compound|aliphatic alcohol]]s, [[hydroxysteroids]], and [[lipid peroxidation]] products. Class III alcohol dehydrogenase is a [[homodimer]] composed of 2 chi subunits. It has virtually no activity for ethanol [[oxidation]], but exhibits high activity for oxidation of long-chain [[primary alcohol]]s and for oxidation of S-hydroxymethyl-glutathione, a spontaneous [[adduct]] between formaldehyde and glutathione.
 
This enzyme is an important component of [[cellular metabolism]] for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes [[lacrymation]], [[rhinitis]], [[pharyngitis]], and [[contact dermatitis]].<ref name="entrez"/>
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==References==
==References==
{{reflist}}
{{reflist}}
==External links==
* {{UCSC gene info|ADH5}}


==Further reading==
==Further reading==
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{{refend}}
{{refend}}
==External links==
* {{UCSC gene info|ADH5}}
{{PDB Gallery|geneid=128}}
{{PDB Gallery|geneid=128}}



Revision as of 08:40, 5 December 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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n/a

RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Alcohol dehydrogenase class-3 is an enzyme that in humans is encoded by the ADH5 gene.[1][2][3]

This gene encodes glutathione-dependent formaldehyde dehydrogenase or the class III alcohol dehydrogenase chi subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class III alcohol dehydrogenase is a homodimer composed of 2 chi subunits. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione.

This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis.[3]

References

  1. Hur MW, Edenberg HJ (Dec 1992). "Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase". Gene. 121 (2): 305–11. doi:10.1016/0378-1119(92)90135-C. PMID 1446828.
  2. Adinolfi A, Adinolfi M, Hopkinson DA (May 1984). "Immunological and biochemical characterization of the human alcohol dehydrogenase chi-ADH isozyme". Ann Hum Genet. 48 (Pt 1): 1–10. doi:10.1111/j.1469-1809.1984.tb00828.x. PMID 6424546.
  3. 3.0 3.1 "Entrez Gene: ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide".

Further reading

External links