EMCN: Difference between revisions
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'''Endomucin''' is a [[protein]] that in humans is encoded by the ''EMCN'' [[gene]].<ref name="Kinoshita_2001">{{cite journal | vauthors = Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M | title = Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity | journal = FEBS Letters | volume = 499 | issue = 1-2 | pages = 121–6 | date = June 2001 | pmid = 11418125 | pmc = | doi = 10.1016/S0014-5793(01)02520-0 }}</ref><ref name="pmid11594763">{{cite journal | vauthors = Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M | title = Human endomucin is an endothelial marker | journal = Biochemical and Biophysical Research Communications | volume = 288 | issue = 1 | pages = 129–36 | date = October 2001 | pmid = 11594763 | pmc = | doi = 10.1006/bbrc.2001.5737 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EMCN endomucin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51705| accessdate = }}</ref> Endomucin is a marker for [[endothelial cells]] | '''Endomucin''' is a [[protein]] that in humans is encoded by the ''EMCN'' [[gene]].<ref name="Kinoshita_2001">{{cite journal | vauthors = Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M | title = Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity | journal = FEBS Letters | volume = 499 | issue = 1-2 | pages = 121–6 | date = June 2001 | pmid = 11418125 | pmc = | doi = 10.1016/S0014-5793(01)02520-0 }}</ref><ref name="pmid11594763">{{cite journal | vauthors = Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M | title = Human endomucin is an endothelial marker | journal = Biochemical and Biophysical Research Communications | volume = 288 | issue = 1 | pages = 129–36 | date = October 2001 | pmid = 11594763 | pmc = | doi = 10.1006/bbrc.2001.5737 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EMCN endomucin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51705| accessdate = }}</ref> Endomucin is a marker for [[endothelial cells]]<ref>1.Liu, C. et al. Human Endomucin Is an Endothelial Marker. Biochemical and Biophysical Research Communications 288, 129-136 (2001).</ref> and [[hematopoietic stem cells]].<ref>{{cite journal |author1=Matsubara A.| year = 2005 | title = Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development. | url = http://jem.rupress.org/content/202/11/1483.long | journal = Journal of Experimental Medicine| volume = 11 || issue = 202 | pages = 1483 | doi=10.1084/jem.20051325|display-authors=etal |pmc=2213340}}</ref> | ||
== Function == | == Function == | ||
EMCN is a [[mucin]]-like [[sialoglycoprotein]] that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.<ref name="Kinoshita_2001" /><ref name="entrez" | EMCN is a [[mucin]]-like [[sialoglycoprotein]] that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.<ref name="Kinoshita_2001" /><ref name="entrez"/> | ||
== References == | == References == | ||
| Line 17: | Line 17: | ||
* {{cite journal | vauthors = Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC | title = Serological identification and expression analysis of gastric cancer-associated genes | journal = British Journal of Cancer | volume = 86 | issue = 11 | pages = 1824–30 | date = June 2002 | pmid = 12087473 | pmc = 2375403 | doi = 10.1038/sj.bjc.6600321 }} | * {{cite journal | vauthors = Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC | title = Serological identification and expression analysis of gastric cancer-associated genes | journal = British Journal of Cancer | volume = 86 | issue = 11 | pages = 1824–30 | date = June 2002 | pmid = 12087473 | pmc = 2375403 | doi = 10.1038/sj.bjc.6600321 }} | ||
* {{cite journal | vauthors = Kuhn A, Brachtendorf G, Kurth F, Sonntag M, Samulowitz U, Metze D, Vestweber D | title = Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin | journal = The Journal of Investigative Dermatology | volume = 119 | issue = 6 | pages = 1388–93 | date = December 2002 | pmid = 12485444 | doi = 10.1046/j.1523-1747.2002.19647.x }} | * {{cite journal | vauthors = Kuhn A, Brachtendorf G, Kurth F, Sonntag M, Samulowitz U, Metze D, Vestweber D | title = Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin | journal = The Journal of Investigative Dermatology | volume = 119 | issue = 6 | pages = 1388–93 | date = December 2002 | pmid = 12485444 | doi = 10.1046/j.1523-1747.2002.19647.x }} | ||
* {{cite journal | vauthors = Kanda H, Tanaka T, Matsumoto M, Umemoto E, Ebisuno Y, Kinoshita M, Noda M, Kannagi R, Hirata T, Murai T, Fukuda M, Miyasaka M | title = Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling | journal = International Immunology | volume = 16 | issue = 9 | pages = 1265–74 | date = September 2004 | pmid = 15249540 | doi = 10.1093/intimm/dxh128 }} | * {{cite journal | vauthors = Kanda H, Tanaka T, Matsumoto M, Umemoto E, Ebisuno Y, Kinoshita M, Noda M, Kannagi R, Hirata T, Murai T, Fukuda M, Miyasaka M | title = Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling | journal = [[International Immunology]] | volume = 16 | issue = 9 | pages = 1265–74 | date = September 2004 | pmid = 15249540 | doi = 10.1093/intimm/dxh128 }} | ||
* {{cite journal |author1=Reckzeh K. |author2=Kizilkaya H. |author3=Søgaard Helbo A. |author4=Estruch Alrich M. | year = 2018 | title = Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin | url = https://doi.org/10.1182/bloodadvances.2018015743 | journal = [[Blood Advances]]| volume = 2 | pages = 1628-1632 | doi=10.1182/bloodadvances.2018015743|display-authors=etal }}</ref> | |||
{{refend}} | {{refend}} | ||
{{gene-4-stub}} | {{gene-4-stub}} | ||
Revision as of 18:53, 21 August 2018
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Endomucin is a protein that in humans is encoded by the EMCN gene.[1][2][3] Endomucin is a marker for endothelial cells[4] and hematopoietic stem cells.[5]
Function
EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.[1][3]
References
- ↑ 1.0 1.1 Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M (June 2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity". FEBS Letters. 499 (1–2): 121–6. doi:10.1016/S0014-5793(01)02520-0. PMID 11418125.
- ↑ Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M (October 2001). "Human endomucin is an endothelial marker". Biochemical and Biophysical Research Communications. 288 (1): 129–36. doi:10.1006/bbrc.2001.5737. PMID 11594763.
- ↑ 3.0 3.1 "Entrez Gene: EMCN endomucin".
- ↑ 1.Liu, C. et al. Human Endomucin Is an Endothelial Marker. Biochemical and Biophysical Research Communications 288, 129-136 (2001).
- ↑ Matsubara A.; et al. (2005). "Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development". Journal of Experimental Medicine. 11 (202): 1483. doi:10.1084/jem.20051325. PMC 2213340.
Further reading
- Li G, Miles A, Line A, Rees RC (March 2004). "Identification of tumour antigens by serological analysis of cDNA expression cloning". Cancer Immunology, Immunotherapy. 53 (3): 139–43. doi:10.1007/s00262-003-0471-y. PMID 14722670.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Samulowitz U, Kuhn A, Brachtendorf G, Nawroth R, Braun A, Bankfalvi A, Böcker W, Vestweber D (May 2002). "Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope". The American Journal of Pathology. 160 (5): 1669–81. doi:10.1016/S0002-9440(10)61114-5. PMC 1850881. PMID 12000719.
- Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC (June 2002). "Serological identification and expression analysis of gastric cancer-associated genes". British Journal of Cancer. 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473.
- Kuhn A, Brachtendorf G, Kurth F, Sonntag M, Samulowitz U, Metze D, Vestweber D (December 2002). "Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin". The Journal of Investigative Dermatology. 119 (6): 1388–93. doi:10.1046/j.1523-1747.2002.19647.x. PMID 12485444.
- Kanda H, Tanaka T, Matsumoto M, Umemoto E, Ebisuno Y, Kinoshita M, Noda M, Kannagi R, Hirata T, Murai T, Fukuda M, Miyasaka M (September 2004). "Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling". International Immunology. 16 (9): 1265–74. doi:10.1093/intimm/dxh128. PMID 15249540.
- Reckzeh K.; Kizilkaya H.; Søgaard Helbo A.; Estruch Alrich M.; et al. (2018). "Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin". Blood Advances. 2: 1628–1632. doi:10.1182/bloodadvances.2018015743.</ref>
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