AH receptor-interacting protein: Difference between revisions
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== Function == | == Function == | ||
AIP may play a positive role in [[aryl hydrocarbon receptor]]-mediated signalling possibly by influencing its receptivity for ligand and/or its nuclear targeting. AIP is the cellular negative regulator of the [[hepatitis B virus]] (HBV) X protein.<ref name="entrez"/> | AIP may play a positive role in [[aryl hydrocarbon receptor]]-mediated signalling possibly by influencing its receptivity for ligand and/or its nuclear targeting. AIP is the cellular negative regulator of the [[hepatitis B virus]] (HBV) X protein.<ref name="entrez"/> Further, it's been known to suppress antiviral signaling and the induction of type I interferon by targeting IRF7, a key player in the antiviral signal pathways.<ref name = "Zhou_2005">{{cite journal | vauthors = Zhou Q, Lavorgna A, Bowman M, Hiscott J, Harhaj EW | title = Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon | journal = The Journal of Biological Chemistry | volume = 290 | issue = 23 | pages = 14729–39 | date = June 2015 | pmid = 25911105 | doi = 10.1074/jbc.M114.633065 | pmc = 4505538 }}</ref> | ||
== Role in disease == | == Role in disease == | ||
AIP mutations may be the cause of a familial form of [[acromegaly]], familial isolated pituitary adenoma (FIPA). Somatotropinomas (i.e. [[Growth hormone|GH]]-producing [[pituitary adenoma]]s), sometimes associated with [[prolactinoma]]s, are present in most AIP mutated patients.<ref name = "pmid20530095">{{cite journal | AIP mutations may be the cause of a familial form of [[acromegaly]], familial isolated pituitary adenoma (FIPA). Somatotropinomas (i.e. [[Growth hormone|GH]]-producing [[pituitary adenoma]]s), sometimes associated with [[prolactinoma]]s, are present in most AIP mutated patients.<ref name="pmid20530095">{{cite journal |vauthors=Occhi G, Trivellin G, Ceccato F |title=Prevalence of AIP mutations in a large series of sporadic Italian acromegalic patients and evaluation of CDKN1B status in acromegalic patients with multiple endocrine neoplasia. |journal=Eur. J. Endocrinol. |year=2010 |volume=163 |issue=3 |pages=369–376 |doi=10.1530/EJE-10-0327 |pmid=20530095 |url=http://eje-online.org/content/163/3/369.long |display-authors=etal |access-date=2012-03-22 |archive-url=https://archive.is/20130414175732/http://eje-online.org/content/163/3/369.long |archive-date=2013-04-14 |dead-url=yes |df= }}</ref> | ||
== Interactions == | == Interactions == | ||
AIP has been shown to [[Protein-protein interaction|interact]] with the [[aryl hydrocarbon receptor]],<ref name = "pmid9111057"/><ref name="pmid10986286">{{cite journal | vauthors = Petrulis JR, Hord NG, Perdew GH | title = Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2 | journal = J. Biol. Chem. | volume = 275 | issue = 48 | pages = 37448–53 |date=December 2000 | pmid = 10986286 | doi = 10.1074/jbc.M006873200 | url = | issn = }}</ref><ref name="pmid9083006">{{cite journal | vauthors = Ma Q, Whitlock JP | title = A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin | journal = J. Biol. Chem. | volume = 272 | issue = 14 | pages = 8878–84 |date=April 1997 | pmid = 9083006 | doi = 10.1074/jbc.272.14.8878| url = | issn = }}</ref> [[peroxisome proliferator-activated receptor alpha]]<ref name="pmid12482853">{{cite journal | vauthors = Sumanasekera WK, Tien ES, Turpey R, Vanden Heuvel JP, Perdew GH | title = Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2 | journal = J. Biol. Chem. | volume = 278 | issue = 7 | pages = 4467–73 |date=February 2003 | pmid = 12482853 | doi = 10.1074/jbc.M211261200 | url = | issn = }}</ref> and the [[aryl hydrocarbon receptor nuclear translocator]].<ref name=pmid9111057/><ref name="pmid11259606">{{cite journal | vauthors = Kazlauskas A, Sundström S, Poellinger L, Pongratz I | title = The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor | journal = Mol. Cell. Biol. | volume = 21 | issue = 7 | pages = 2594–607 |date=April 2001 | pmid = 11259606 | pmc = 86890 | doi = 10.1128/MCB.21.7.2594-2607.2001 | url = | issn = }}</ref> | AIP has been shown to [[Protein-protein interaction|interact]] with the [[aryl hydrocarbon receptor]],<ref name = "pmid9111057"/><ref name="pmid10986286">{{cite journal | vauthors = Petrulis JR, Hord NG, Perdew GH | title = Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2 | journal = J. Biol. Chem. | volume = 275 | issue = 48 | pages = 37448–53 |date=December 2000 | pmid = 10986286 | doi = 10.1074/jbc.M006873200 | url = | issn = }}</ref><ref name="pmid9083006">{{cite journal | vauthors = Ma Q, Whitlock JP | title = A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin | journal = J. Biol. Chem. | volume = 272 | issue = 14 | pages = 8878–84 |date=April 1997 | pmid = 9083006 | doi = 10.1074/jbc.272.14.8878| url = | issn = }}</ref> [[peroxisome proliferator-activated receptor alpha]]<ref name="pmid12482853">{{cite journal | vauthors = Sumanasekera WK, Tien ES, Turpey R, Vanden Heuvel JP, Perdew GH | title = Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2 | journal = J. Biol. Chem. | volume = 278 | issue = 7 | pages = 4467–73 |date=February 2003 | pmid = 12482853 | doi = 10.1074/jbc.M211261200 | url = | issn = }}</ref> and the [[aryl hydrocarbon receptor nuclear translocator]].<ref name=pmid9111057/><ref name="pmid11259606">{{cite journal | vauthors = Kazlauskas A, Sundström S, Poellinger L, Pongratz I | title = The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor | journal = Mol. Cell. Biol. | volume = 21 | issue = 7 | pages = 2594–607 |date=April 2001 | pmid = 11259606 | pmc = 86890 | doi = 10.1128/MCB.21.7.2594-2607.2001 | url = | issn = }}</ref> Further, it has shown that AIP can interact with IRF7 to exert its novel function of negatively regulating antiviral signal pathways.<ref name = "Zhou_2005" /> | ||
==References== | ==References== | ||
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==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin|2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | vauthors=Zhou Q, Lavorgna A |title=Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon. |journal=Journal of Biological Chemistry |year=2015 |volume=290 |pages=14729–14739 |doi=10.1074/jbc.M114.633065 |url=http://www.jbc.org/content/290/23/14729.short |display-authors=etal|pmc=4505538 }} | |||
*{{cite journal | vauthors=Chen HS, Perdew GH |title=Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex. |journal=J. Biol. Chem. |volume=269 |issue= 44 |pages= 27554–8 |year= 1994 |pmid= 7961671 |doi= }} | *{{cite journal | vauthors=Chen HS, Perdew GH |title=Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex. |journal=J. Biol. Chem. |volume=269 |issue= 44 |pages= 27554–8 |year= 1994 |pmid= 7961671 |doi= }} | ||
*{{cite journal | vauthors=Ma Q, Whitlock JP |title=A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 8878–84 |year= 1997 |pmid= 9083006 |doi=10.1074/jbc.272.14.8878 }} | *{{cite journal | vauthors=Ma Q, Whitlock JP |title=A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 8878–84 |year= 1997 |pmid= 9083006 |doi=10.1074/jbc.272.14.8878 }} | ||
| Line 39: | Line 40: | ||
*{{cite journal | vauthors=Yano M, Terada K, Mori M |title=AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins. |journal=J. Cell Biol. |volume=163 |issue= 1 |pages= 45–56 |year= 2003 |pmid= 14557246 | pmc=2173431 |doi= 10.1083/jcb.200305051 }} | *{{cite journal | vauthors=Yano M, Terada K, Mori M |title=AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins. |journal=J. Cell Biol. |volume=163 |issue= 1 |pages= 45–56 |year= 2003 |pmid= 14557246 | pmc=2173431 |doi= 10.1083/jcb.200305051 }} | ||
*{{cite journal | vauthors=Ramadoss P, Petrulis JR, Hollingshead BD |title=Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes. |journal=Biochemistry |volume=43 |issue= 3 |pages= 700–9 |year= 2004 |pmid= 14730974 |doi= 10.1021/bi035827v |display-authors=etal}} | *{{cite journal | vauthors=Ramadoss P, Petrulis JR, Hollingshead BD |title=Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes. |journal=Biochemistry |volume=43 |issue= 3 |pages= 700–9 |year= 2004 |pmid= 14730974 |doi= 10.1021/bi035827v |display-authors=etal}} | ||
*{{cite journal | *{{cite journal |vauthors=Occhi G, Trivellin G, Ceccato F |title=Prevalence of AIP mutations in a large series of sporadic Italian acromegalic patients and evaluation of CDKN1B status in acromegalic patients with multiple endocrine neoplasia. |journal=Eur. J. Endocrinol. |year=2010 |volume=163 |issue=3 |pages=369–376 |doi=10.1530/EJE-10-0327 |pmid=20530095 |url=http://eje-online.org/content/163/3/369.long |display-authors=etal |access-date=2012-03-22 |archive-url=https://archive.is/20130414175732/http://eje-online.org/content/163/3/369.long |archive-date=2013-04-14 |dead-url=yes |df= }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
Latest revision as of 03:15, 28 September 2018
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AH receptor-interacting protein (AIP) also known as aryl-hydrocarbon receptor-interacting protein, immunophilin homolog ARA9, or HBV X-associated protein 2 (XAP-2) is a protein that in humans is encoded by the AIP gene.[1][2][3] The protein is a member of FKBP family.
Function
AIP may play a positive role in aryl hydrocarbon receptor-mediated signalling possibly by influencing its receptivity for ligand and/or its nuclear targeting. AIP is the cellular negative regulator of the hepatitis B virus (HBV) X protein.[1] Further, it's been known to suppress antiviral signaling and the induction of type I interferon by targeting IRF7, a key player in the antiviral signal pathways.[4]
Role in disease
AIP mutations may be the cause of a familial form of acromegaly, familial isolated pituitary adenoma (FIPA). Somatotropinomas (i.e. GH-producing pituitary adenomas), sometimes associated with prolactinomas, are present in most AIP mutated patients.[5]
Interactions
AIP has been shown to interact with the aryl hydrocarbon receptor,[3][6][7] peroxisome proliferator-activated receptor alpha[8] and the aryl hydrocarbon receptor nuclear translocator.[3][9] Further, it has shown that AIP can interact with IRF7 to exert its novel function of negatively regulating antiviral signal pathways.[4]
References
- ↑ 1.0 1.1 "Entrez Gene: AIP aryl hydrocarbon receptor interacting protein".
- ↑ Kuzhandaivelu N, Cong YS, Inouye C, Yang WM, Seto E (December 1996). "XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation". Nucleic Acids Res. 24 (23): 4741–50. doi:10.1093/nar/24.23.4741. PMC 146319. PMID 8972861.
- ↑ 3.0 3.1 3.2 Carver LA, Bradfield CA (April 1997). "Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo". J. Biol. Chem. 272 (17): 11452–6. doi:10.1074/jbc.272.17.11452. PMID 9111057.
- ↑ 4.0 4.1 Zhou Q, Lavorgna A, Bowman M, Hiscott J, Harhaj EW (June 2015). "Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon". The Journal of Biological Chemistry. 290 (23): 14729–39. doi:10.1074/jbc.M114.633065. PMC 4505538. PMID 25911105.
- ↑ Occhi G, Trivellin G, Ceccato F, et al. (2010). "Prevalence of AIP mutations in a large series of sporadic Italian acromegalic patients and evaluation of CDKN1B status in acromegalic patients with multiple endocrine neoplasia". Eur. J. Endocrinol. 163 (3): 369–376. doi:10.1530/EJE-10-0327. PMID 20530095. Archived from the original on 2013-04-14. Retrieved 2012-03-22.
- ↑ Petrulis JR, Hord NG, Perdew GH (December 2000). "Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2". J. Biol. Chem. 275 (48): 37448–53. doi:10.1074/jbc.M006873200. PMID 10986286.
- ↑ Ma Q, Whitlock JP (April 1997). "A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin". J. Biol. Chem. 272 (14): 8878–84. doi:10.1074/jbc.272.14.8878. PMID 9083006.
- ↑ Sumanasekera WK, Tien ES, Turpey R, Vanden Heuvel JP, Perdew GH (February 2003). "Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2". J. Biol. Chem. 278 (7): 4467–73. doi:10.1074/jbc.M211261200. PMID 12482853.
- ↑ Kazlauskas A, Sundström S, Poellinger L, Pongratz I (April 2001). "The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor". Mol. Cell. Biol. 21 (7): 2594–607. doi:10.1128/MCB.21.7.2594-2607.2001. PMC 86890. PMID 11259606.
Further reading
- Zhou Q, Lavorgna A, et al. (2015). "Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon". Journal of Biological Chemistry. 290: 14729–14739. doi:10.1074/jbc.M114.633065. PMC 4505538.
- Chen HS, Perdew GH (1994). "Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex". J. Biol. Chem. 269 (44): 27554–8. PMID 7961671.
- Ma Q, Whitlock JP (1997). "A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin". J. Biol. Chem. 272 (14): 8878–84. doi:10.1074/jbc.272.14.8878. PMID 9083006.
- Meyer BK, Pray-Grant MG, Vanden Heuvel JP, Perdew GH (1998). "Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity". Mol. Cell. Biol. 18 (2): 978–88. PMC 108810. PMID 9447995.
- Carver LA, LaPres JJ, Jain S, et al. (1999). "Characterization of the Ah receptor-associated protein, ARA9". J. Biol. Chem. 273 (50): 33580–7. doi:10.1074/jbc.273.50.33580. PMID 9837941.
- Gadelha MR, Une KN, Rohde K, et al. (2000). "Isolated familial somatotropinomas: establishment of linkage to chromosome 11q13.1-11q13.3 and evidence for a potential second locus at chromosome 2p16-12". J. Clin. Endocrinol. Metab. 85 (2): 707–14. doi:10.1210/jc.85.2.707. PMID 10690880.
- Petrulis JR, Hord NG, Perdew GH (2001). "Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2". J. Biol. Chem. 275 (48): 37448–53. doi:10.1074/jbc.M006873200. PMID 10986286.
- Kazlauskas A, Poellinger L, Pongratz I (2001). "The immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor". J. Biol. Chem. 275 (52): 41317–24. doi:10.1074/jbc.M007765200. PMID 11013261.
- Kazlauskas A, Sundström S, Poellinger L, Pongratz I (2001). "The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor". Mol. Cell. Biol. 21 (7): 2594–607. doi:10.1128/MCB.21.7.2594-2607.2001. PMC 86890. PMID 11259606.
- Kazlauskas A, Poellinger L, Pongratz I (2002). "Two distinct regions of the immunophilin-like protein XAP2 regulate dioxin receptor function and interaction with hsp90". J. Biol. Chem. 277 (14): 11795–801. doi:10.1074/jbc.M200053200. PMID 11805120.
- Patterson CE, Gao J, Rooney AP, Davis EC (2002). "Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family". Genomics. 79 (6): 881–9. doi:10.1006/geno.2002.6777. PMID 12036304.
- Berg P, Pongratz I (2002). "Two parallel pathways mediate cytoplasmic localization of the dioxin (aryl hydrocarbon) receptor". J. Biol. Chem. 277 (35): 32310–9. doi:10.1074/jbc.M203351200. PMID 12065584.
- Dull AB, Carlson DB, Petrulis JR, Perdew GH (2002). "Characterization of the phosphorylation status of the hepatitis B virus X-associated protein 2". Arch. Biochem. Biophys. 406 (2): 209–21. doi:10.1016/S0003-9861(02)00444-7. PMID 12361709.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sumanasekera WK, Tien ES, Turpey R, et al. (2003). "Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2". J. Biol. Chem. 278 (7): 4467–73. doi:10.1074/jbc.M211261200. PMID 12482853.
- Zhao Y, Meng XM, Wei YJ, et al. (2004). "Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I.". J. Mol. Med. 81 (5): 297–304. doi:10.1007/s00109-003-0427-x. PMID 12721663.
- Lees MJ, Peet DJ, Whitelaw ML (2003). "Defining the role for XAP2 in stabilization of the dioxin receptor". J. Biol. Chem. 278 (38): 35878–88. doi:10.1074/jbc.M302430200. PMID 12837759.
- Yano M, Terada K, Mori M (2003). "AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins". J. Cell Biol. 163 (1): 45–56. doi:10.1083/jcb.200305051. PMC 2173431. PMID 14557246.
- Ramadoss P, Petrulis JR, Hollingshead BD, et al. (2004). "Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes". Biochemistry. 43 (3): 700–9. doi:10.1021/bi035827v. PMID 14730974.
- Occhi G, Trivellin G, Ceccato F, et al. (2010). "Prevalence of AIP mutations in a large series of sporadic Italian acromegalic patients and evaluation of CDKN1B status in acromegalic patients with multiple endocrine neoplasia". Eur. J. Endocrinol. 163 (3): 369–376. doi:10.1530/EJE-10-0327. PMID 20530095. Archived from the original on 2013-04-14. Retrieved 2012-03-22.