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{{Infobox_gene}}
{{Infobox_gene}}
'''Rhombotin-1''' is a [[protein]] that in humans is encoded by the ''LMO1'' [[gene]].<ref name="pmid2034676">{{cite journal |vauthors=Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH | title = The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13 | journal = Proc Natl Acad Sci U S A | volume = 88 | issue = 10 | pages = 4367–71 |date=June 1991 | pmid = 2034676 | pmc = 51660 | doi =10.1073/pnas.88.10.4367  }}</ref><ref name="pmid1703797">{{cite journal |vauthors=McGuire EA, Davis AR, Korsmeyer SJ | title = T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells | journal = Blood | volume = 77 | issue = 3 | pages = 599–606 |date=March 1991 | pmid = 1703797 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4004| accessdate = }}</ref>
'''Rhombotin-1''' is a [[protein]] that in humans is encoded by the ''LMO1'' [[gene]].<ref name="pmid2034676">{{cite journal |vauthors=Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH | title = The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13 | journal = Proc Natl Acad Sci U S A | volume = 88 | issue = 10 | pages = 4367–71 |date=June 1991 | pmid = 2034676 | pmc = 51660 | doi =10.1073/pnas.88.10.4367  | bibcode =1991PNAS...88.4367B }}</ref><ref name="pmid1703797">{{cite journal |vauthors=McGuire EA, Davis AR, Korsmeyer SJ | title = T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells | journal = Blood | volume = 77 | issue = 3 | pages = 599–606 |date=March 1991 | pmid = 1703797 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4004| accessdate = }}</ref>


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==Interactions==
==Interactions==
LMO1 has been shown to [[Protein-protein interaction|interact]] with [[GATA3]]<ref name=pmid9819382>{{cite journal |last=Ono |first=Y |authorlink= |author2=Fukuhara N |author3=Yoshie O  |date=December 1998  |title=TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3 |journal=Mol. Cell. Biol. |volume=18 |issue=12 |pages=6939–50 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 9819382 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=109277 }}</ref><ref name=pmid9020185>{{cite journal |last=Ono |first=Y |authorlink= |author2=Fukuhara N |author3=Yoshie O  |date=February 1997  |title=Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL |journal=J. Biol. Chem. |volume=272 |issue=7 |pages=4576–81 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9020185 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.272.7.4576 }}</ref> and [[TAL1]].<ref name=pmid8078932>{{cite journal |last=Valge-Archer |first=V E |authorlink= |author2=Osada H |author3=Warren A J |author4=Forster A |author5=Li J |author6=Baer R |author7=Rabbitts T H  |date=August 1994  |title=The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=91 |issue=18 |pages=8617–21 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8078932 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.91.18.8617 |pmc=44657 }}</ref><ref name=pmid7957052>{{cite journal |last=Wadman |first=I |authorlink= |author2=Li J |author3=Bash R O |author4=Forster A |author5=Osada H |author6=Rabbitts T H |author7=Baer R  |date=October 1994  |title=Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia |journal=EMBO J. |volume=13 |issue=20 |pages=4831–9 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 7957052 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=395422 }}</ref>
LMO1 has been shown to [[Protein-protein interaction|interact]] with [[GATA3]]<ref name=pmid9819382>{{cite journal |last=Ono |first=Y |authorlink= |author2=Fukuhara N |author3=Yoshie O  |date=December 1998  |title=TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3 |journal=Mol. Cell. Biol. |volume=18 |issue=12 |pages=6939–50 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 9819382 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=109277 }}</ref><ref name=pmid9020185>{{cite journal |last=Ono |first=Y |authorlink= |author2=Fukuhara N |author3=Yoshie O  |date=February 1997  |title=Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL |journal=J. Biol. Chem. |volume=272 |issue=7 |pages=4576–81 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9020185 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.272.7.4576 }}</ref> and [[TAL1]].<ref name=pmid8078932>{{cite journal |last=Valge-Archer |first=V E |authorlink= |author2=Osada H |author3=Warren A J |author4=Forster A |author5=Li J |author6=Baer R |author7=Rabbitts T H  |date=August 1994  |title=The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=91 |issue=18 |pages=8617–21 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8078932 | bibcode =1994PNAS...91.8617V | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.91.18.8617 |pmc=44657 }}</ref><ref name=pmid7957052>{{cite journal |last=Wadman |first=I |authorlink= |author2=Li J |author3=Bash R O |author4=Forster A |author5=Osada H |author6=Rabbitts T H |author7=Baer R  |date=October 1994  |title=Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia |journal=EMBO J. |volume=13 |issue=20 |pages=4831–9 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 7957052 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=395422 }}</ref>


==References==
==References==
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*{{cite journal  |vauthors=Boehm T, Baer R, Lavenir I, etal |title=The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15. |journal=EMBO J. |volume=7 |issue= 2 |pages= 385–94 |year= 1988 |pmid= 3259177 |doi=  | pmc=454331  }}
*{{cite journal  |vauthors=Boehm T, Baer R, Lavenir I, etal |title=The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15. |journal=EMBO J. |volume=7 |issue= 2 |pages= 385–94 |year= 1988 |pmid= 3259177 |doi=  | pmc=454331  }}
*{{cite journal  |vauthors=Wadman I, Li J, Bash RO, etal |title=Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. |journal=EMBO J. |volume=13 |issue= 20 |pages= 4831–9 |year= 1994 |pmid= 7957052 |doi=  | pmc=395422  }}
*{{cite journal  |vauthors=Wadman I, Li J, Bash RO, etal |title=Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. |journal=EMBO J. |volume=13 |issue= 20 |pages= 4831–9 |year= 1994 |pmid= 7957052 |doi=  | pmc=395422  }}
*{{cite journal  |vauthors=Valge-Archer VE, Osada H, Warren AJ, etal |title=The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 18 |pages= 8617–21 |year= 1994 |pmid= 8078932 |doi=10.1073/pnas.91.18.8617  | pmc=44657  }}
*{{cite journal  |vauthors=Valge-Archer VE, Osada H, Warren AJ, etal |title=The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 18 |pages= 8617–21 |year= 1994 |pmid= 8078932 |doi=10.1073/pnas.91.18.8617  | pmc=44657  |bibcode=1994PNAS...91.8617V }}
*{{cite journal  |vauthors=Arber S, Caroni P |title=Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ. |journal=Genes Dev. |volume=10 |issue= 3 |pages= 289–300 |year= 1996 |pmid= 8595880 |doi=10.1101/gad.10.3.289  }}
*{{cite journal  |vauthors=Arber S, Caroni P |title=Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ. |journal=Genes Dev. |volume=10 |issue= 3 |pages= 289–300 |year= 1996 |pmid= 8595880 |doi=10.1101/gad.10.3.289  }}
*{{cite journal  |vauthors=Jurata LW, Kenny DA, Gill GN |title=Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 21 |pages= 11693–8 |year= 1996 |pmid= 8876198 |doi=10.1073/pnas.93.21.11693  | pmc=38120  }}
*{{cite journal  |vauthors=Jurata LW, Kenny DA, Gill GN |title=Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 21 |pages= 11693–8 |year= 1996 |pmid= 8876198 |doi=10.1073/pnas.93.21.11693  | pmc=38120  |bibcode=1996PNAS...9311693J }}
*{{cite journal  |vauthors=Ono Y, Fukuhara N, Yoshie O |title=Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4576–81 |year= 1997 |pmid= 9020185 |doi=10.1074/jbc.272.7.4576  }}
*{{cite journal  |vauthors=Ono Y, Fukuhara N, Yoshie O |title=Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4576–81 |year= 1997 |pmid= 9020185 |doi=10.1074/jbc.272.7.4576  }}
*{{cite journal  |vauthors=Valge-Archer V, Forster A, Rabbitts TH |title=The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11). |journal=Oncogene |volume=17 |issue= 24 |pages= 3199–202 |year= 1999 |pmid= 9872335 |doi= 10.1038/sj.onc.1202353 }}
*{{cite journal  |vauthors=Valge-Archer V, Forster A, Rabbitts TH |title=The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11). |journal=Oncogene |volume=17 |issue= 24 |pages= 3199–202 |year= 1999 |pmid= 9872335 |doi= 10.1038/sj.onc.1202353 }}
*{{cite journal  |vauthors=Bao J, Talmage DA, Role LW, Gautier J |title=Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins. |journal=Development |volume=127 |issue= 2 |pages= 425–35 |year= 2000 |pmid= 10603358 |doi=  }}
*{{cite journal  |vauthors=Bao J, Talmage DA, Role LW, Gautier J |title=Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins. |journal=Development |volume=127 |issue= 2 |pages= 425–35 |year= 2000 |pmid= 10603358 |doi=  }}
*{{cite journal  |vauthors=Cichutek A, Brueckmann T, Seipel B, etal |title=Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). |journal=Cytogenet. Cell Genet. |volume=93 |issue= 3–4 |pages= 277–83 |year= 2001 |pmid= 11528126 |doi=10.1159/000056998  }}
*{{cite journal  |vauthors=Cichutek A, Brueckmann T, Seipel B, etal |title=Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). |journal=Cytogenet. Cell Genet. |volume=93 |issue= 3–4 |pages= 277–83 |year= 2001 |pmid= 11528126 |doi=10.1159/000056998  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  |vauthors=Lin YW, Deveney R, Barbara M, etal |title=OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1 |journal=Cancer Res. |volume=65 |issue= 16 |pages= 7151–8 |year= 2005 |pmid= 16103065 |doi= 10.1158/0008-5472.CAN-05-1400  | pmc=1681523 }}
*{{cite journal  |vauthors=Lin YW, Deveney R, Barbara M, etal |title=OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1 |journal=Cancer Res. |volume=65 |issue= 16 |pages= 7151–8 |year= 2005 |pmid= 16103065 |doi= 10.1158/0008-5472.CAN-05-1400  | pmc=1681523 }}

Latest revision as of 18:36, 24 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.[1][2][3]

LMO1 encodes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.[3]

Interactions

LMO1 has been shown to interact with GATA3[4][5] and TAL1.[6][7]

References

  1. Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (June 1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13". Proc Natl Acad Sci U S A. 88 (10): 4367–71. Bibcode:1991PNAS...88.4367B. doi:10.1073/pnas.88.10.4367. PMC 51660. PMID 2034676.
  2. McGuire EA, Davis AR, Korsmeyer SJ (March 1991). "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells". Blood. 77 (3): 599–606. PMID 1703797.
  3. 3.0 3.1 "Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)".
  4. Ono, Y; Fukuhara N; Yoshie O (December 1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3". Mol. Cell. Biol. UNITED STATES. 18 (12): 6939–50. ISSN 0270-7306. PMC 109277. PMID 9819382.
  5. Ono, Y; Fukuhara N; Yoshie O (February 1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL". J. Biol. Chem. UNITED STATES. 272 (7): 4576–81. doi:10.1074/jbc.272.7.4576. ISSN 0021-9258. PMID 9020185.
  6. Valge-Archer, V E; Osada H; Warren A J; Forster A; Li J; Baer R; Rabbitts T H (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 91 (18): 8617–21. Bibcode:1994PNAS...91.8617V. doi:10.1073/pnas.91.18.8617. ISSN 0027-8424. PMC 44657. PMID 8078932.
  7. Wadman, I; Li J; Bash R O; Forster A; Osada H; Rabbitts T H; Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. ENGLAND. 13 (20): 4831–9. ISSN 0261-4189. PMC 395422. PMID 7957052.

Further reading