'''Transgelin''' is a [[protein]] that in humans is encoded by the ''TAGLN'' [[gene]].<ref name="pmid8117285">{{cite journal | vauthors = Kobayashi R, Kubota T, Hidaka H | title = Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog | journal = Biochem Biophys Res Commun | volume = 198 | issue = 3 | pages = 1275–80 |date=Mar 1994 | pmid = 8117285 | pmc = | doi = 10.1006/bbrc.1994.1180 }}</ref><ref name="pmid1520290">{{cite journal | vauthors = Thweatt R, ((Lumpkin CK Jr)), Goldstein S | title = A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts | journal = Biochem Biophys Res Commun | volume = 187 | issue = 1 | pages = 1–7 |date=Oct 1992 | pmid = 1520290 | pmc = | doi =10.1016/S0006-291X(05)81449-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAGLN transgelin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6876| accessdate = }}</ref>
'''Transgelin''' is a [[protein]] that in humans is encoded by the ''TAGLN'' [[gene]].<ref name="pmid8117285">{{cite journal | vauthors = Kobayashi R, Kubota T, Hidaka H | title = Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog | journal = Biochem Biophys Res Commun | volume = 198 | issue = 3 | pages = 1275–80 |date=Mar 1994 | pmid = 8117285 | pmc = | doi = 10.1006/bbrc.1994.1180 }}</ref><ref name="pmid1520290">{{cite journal | vauthors = Thweatt R, ((Lumpkin CK Jr)), Goldstein S | title = A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts | journal = Biochem Biophys Res Commun | volume = 187 | issue = 1 | pages = 1–7 |date=Oct 1992 | pmid = 1520290 | pmc = | doi =10.1016/S0006-291X(05)81449-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAGLN transgelin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6876| accessdate = }}</ref>
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.<ref name="entrez" />
The protein encoded by this gene is a transformation and shape-change sensitive [[actin]] cross-linking/gelling protein found in [[fibroblast|fibroblasts]] and [[smooth muscle]]. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two [[transcript variant|transcript variants]] encoding the same protein have been found for this gene.<ref name="entrez" />
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.[3]
References
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↑Thweatt R, Lumpkin CK Jr, Goldstein S (Oct 1992). "A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts". Biochem Biophys Res Commun. 187 (1): 1–7. doi:10.1016/S0006-291X(05)81449-4. PMID1520290.
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