This gene encodes a protein belonging to the [[Ran (gene)|RAN-GTPase]] exportin family that mediates export of [[Transfer RNA|tRNA]] from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once [[Karyopherin|exportin]] has bound both tRNA and GTP-bound RAN.<ref name="entrez" />
This gene encodes a protein belonging to the [[Ran (gene)|RAN-GTPase]] exportin family that mediates export of [[Transfer RNA|tRNA]] from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once [[Karyopherin|exportin]] has bound both tRNA and GTP-bound RAN.<ref name="entrez" />
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.[3]
References
↑Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Gorlich D (Jul 1998). "Identification of a tRNA-specific nuclear export receptor". Mol Cell. 1 (3): 359–69. doi:10.1016/S1097-2765(00)80036-2. PMID9660920.
Kutay U, Hartmann E, Treichel N, et al. (2001). "Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily". J. Biol. Chem. 275 (51): 40163–8. doi:10.1074/jbc.M006242200. PMID11024021.
Suzuki T, Koyama Y, Hayakawa S, et al. (2006). "1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells". Biomed. Res. 27 (2): 89–92. doi:10.2220/biomedres.27.89. PMID16707848.
Li S, Sprinzl M (2007). "Interaction of immobilized human exportin-t with calf liver tRNA". RNA Biol. 3 (4): 145–9. doi:10.4161/rna.3.4.3679. PMID17224653.
