*{{cite journal |vauthors=Young DJ, Edgar CD, Murphy J, etal | title= Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria. | journal=RNA |volume= 16 |pages= 1146–55 |year= 2010 |pmid= 20421313 |doi=10.1261/rna.1970310 |issue=6 |pmc=2874167}}
*{{cite journal |vauthors=Young DJ, Edgar CD, Murphy J, etal | title= Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria. | journal=RNA |volume= 16 |pages= 1146–55 |year= 2010 |pmid= 20421313 |doi=10.1261/rna.1970310 |issue=6 |pmc=2874167}}
*{{cite journal|last=Huynen, MA|first=Martijn|author2=Duarte I |author3=Chrzanowska-Lightowlers ZM |author4=Nabuurs SB. |title=Structure based hypothesis of a mitochondrial ribosome rescue mechanism.|journal=Biology Direct|date=8 May 2012|volume=7|issue=1|pages=14|doi=10.1186/1745-6150-7-14|pmid=22569235|pmc=3418547}}
*{{cite journal|last=Huynen, MA|first=Martijn|author2=Duarte I |author3=Chrzanowska-Lightowlers ZM |author4=Nabuurs SB. |title=Structure based hypothesis of a mitochondrial ribosome rescue mechanism.|journal=Biology Direct|date=8 May 2012|volume=7|issue=1|pages=14|doi=10.1186/1745-6150-7-14|pmid=22569235|pmc=3418547}}
*{{cite journal|last=Lind |first=C |author2=Sund J| author3=Åqvist J| title=Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons.|journal=Nature Communications |year=2013|doi=10.1038/ncomms3940|volume=4}}
Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.[1][2]
The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty.
References
↑Zhang Y, Spremulli LL (November 1998). "Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor". Biochimica et Biophysica Acta. 1443 (1–2): 245–50. doi:10.1016/S0167-4781(98)00223-1. PMID9838146.
↑Hansen LL, Jørgensen R, Justesen J (2000). "Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping". Cytogenetics and Cell Genetics. 88 (1–2): 91–2. doi:10.1159/000015494. PMID10773675.
Further reading
Nozaki Y, Matsunaga N, Ishizawa T, et al. (2008). "HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG". Genes Cells. 13 (5): 429–38. doi:10.1111/j.1365-2443.2008.01181.x. PMID18429816.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.