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'''Chondroitin sulfate proteoglycan 4''', also known as '''melanoma-associated chondroitin sulfate proteoglycan''' ('''MCSP''') or '''neuron-glial antigen 2''' ('''NG2'''), is a [[chondroitin sulfate proteoglycan]] that in humans is encoded by the ''CSPG4'' [[gene]].<ref name="pmid8790396">{{cite journal | vauthors = Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA | title = Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 18 | pages = 9710–5 |date=Oct 1996 | pmid = 8790396 | pmc = 38494 | doi =10.1073/pnas.93.18.9710 }}</ref><ref name="pmid16407841">{{cite journal | vauthors = Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S | title = Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells | journal = Oncogene | volume = 25 | issue = 20 | pages = 2873–84 |date=May 2006 | pmid = 16407841 | pmc =  | doi = 10.1038/sj.onc.1209319 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1464| accessdate = }}</ref>
'''Chondroitin sulfate proteoglycan 4''', also known as '''melanoma-associated chondroitin sulfate proteoglycan''' ('''MCSP''') or '''neuron-glial antigen 2''' ('''NG2'''), is a [[chondroitin sulfate proteoglycan]] that in humans is encoded by the ''CSPG4'' [[gene]].<ref name="pmid8790396">{{cite journal | vauthors = Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA | title = Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 18 | pages = 9710–5 | date = September 1996 | pmid = 8790396 | pmc = 38494 | doi = 10.1073/pnas.93.18.9710 }}</ref><ref name="pmid16407841">{{cite journal | vauthors = Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S | title = Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells | journal = Oncogene | volume = 25 | issue = 20 | pages = 2873–84 | date = May 2006 | pmid = 16407841 | pmc =  | doi = 10.1038/sj.onc.1209319 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1464| access-date = }}</ref>


CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on [[endothelium|endothelial]] [[basement membrane]]s. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human [[melanoma|malignant melanoma]] cells.<ref name="entrez" />
CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on [[endothelium|endothelial]] [[basement membrane]]s. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human [[melanoma|malignant melanoma]] cells.<ref name="entrez" />


==See also==
CSPG4/NG2 is also a hallmark protein of [[Oligodendrocyte progenitor cell|oligodendrocyte progenitor cells]] (OPCs)<ref>{{cite journal | vauthors = Nishiyama A, Dahlin KJ, Prince JT, Johnstone SR, Stallcup WB | title = The primary structure of NG2, a novel membrane-spanning proteoglycan | journal = The Journal of Cell Biology | volume = 114 | issue = 2 | pages = 359–71 | date = July 1991 | pmid = 1906475 | pmc = 2289079 }}</ref> and OPC dysfunction has been implicated as a candidate pathophysiological mechanism of familial schizophrenia.<ref>{{cite journal | vauthors = de Vrij FM, Bouwkamp CG, Gunhanlar N, Shpak G, Lendemeijer B, Baghdadi M, Gopalakrishna S, Ghazvini M, Li TM, Quadri M, Olgiati S, Breedveld GJ, Coesmans M, Mientjes E, de Wit T, Verheijen FW, Beverloo HB, Cohen D, Kok RM, Bakker PR, Nijburg A, Spijker AT, Haffmans PM, Hoencamp E, Bergink V, Vorstman JA, Wu T, Olde Loohuis LM, Amin N, Langen CD, Hofman A, Hoogendijk WJ, van Duijn CM, Ikram MA, Vernooij MW, Tiemeier H, Uitterlinden AG, Elgersma Y, Distel B, Gribnau J, White T, Bonifati V, Kushner SA | title = Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia | journal = Molecular Psychiatry | date = January 2018 | pmid = 29302076 | doi = 10.1038/s41380-017-0004-2 }}</ref> A research group investigating the role of genetics in [[schizophrenia]], reported, two rare [[Missense mutation|missense mutations]] in ''CSPG4'' gene'','' segregating within families (''CSPG4<sup>A131T</sup>'' and ''CSPG4<sup>V901G</sup>'' mutations). The researchers also demonstrate that the [[Induced pluripotent stem cell|induced pluripotent stem cells]] (iPSCs)-derived OPCs from ''CSPG4<sup>A131T</sup>'' mutation carriers exhibited abnormal post-translational processing, subcellular localization of the mutant NG2 protein, aberrant cellular morphology, and a decreased cell viability and myelination potential. ''In vivo'' [[Diffusion MRI|diffusion tensor imaging]] of the brain of ''CSPG4<sup>A131T</sup>'' mutation carriers demonstrated a reduced [[white matter]] integrity compared to the unaffected sibling and matched general population controls.<ref>{{cite journal | vauthors = de Vrij FM, Bouwkamp CG, Gunhanlar N, Shpak G, Lendemeijer B, Baghdadi M, Gopalakrishna S, Ghazvini M, Li TM, Quadri M, Olgiati S, Breedveld GJ, Coesmans M, Mientjes E, de Wit T, Verheijen FW, Beverloo HB, Cohen D, Kok RM, Bakker PR, Nijburg A, Spijker AT, Haffmans PM, Hoencamp E, Bergink V, Vorstman JA, Wu T, Olde Loohuis LM, Amin N, Langen CD, Hofman A, Hoogendijk WJ, van Duijn CM, Ikram MA, Vernooij MW, Tiemeier H, Uitterlinden AG, Elgersma Y, Distel B, Gribnau J, White T, Bonifati V, Kushner SA | title = Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia | journal = Molecular Psychiatry | date = January 2018 | pmid = 29302076 | doi = 10.1038/s41380-017-0004-2 }}</ref>
 
== See also ==
* [[NG2-glia]]
* [[NG2-glia]]


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal | vauthors=Kirschfink M, Blase L, Engelmann S, Schwartz-Albiez R |title=Secreted chondroitin sulfate proteoglycan of human B cell lines binds to the complement protein C1q and inhibits complex formation of C1. |journal=J. Immunol. |volume=158 |issue= 3 |pages= 1324–31 |year= 1997 |pmid= 9013976 |doi=  }}
* {{cite journal | vauthors = Kirschfink M, Blase L, Engelmann S, Schwartz-Albiez R | title = Secreted chondroitin sulfate proteoglycan of human B cell lines binds to the complement protein C1q and inhibits complex formation of C1 | journal = Journal of Immunology | volume = 158 | issue = 3 | pages = 1324–31 | date = February 1997 | pmid = 9013976 | doi =  }}
*{{cite journal | vauthors=Iida J, Meijne AM, Oegema TR |title=A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5955–62 |year= 1998 |pmid= 9488735 |doi=10.1074/jbc.273.10.5955 |display-authors=etal}}
* {{cite journal | vauthors = Iida J, Meijne AM, Oegema TR, Yednock TA, Kovach NL, Furcht LT, McCarthy JB | title = A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion | journal = The Journal of Biological Chemistry | volume = 273 | issue = 10 | pages = 5955–62 | date = March 1998 | pmid = 9488735 | doi = 10.1074/jbc.273.10.5955 }}
*{{cite journal | vauthors=Eisenmann KM, McCarthy JB, Simpson MA |title=Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. |journal=Nat. Cell Biol. |volume=1 |issue= 8 |pages= 507–13 |year= 2000 |pmid= 10587647 |doi= 10.1038/70302 |display-authors=etal}}
* {{cite journal | vauthors = Eisenmann KM, McCarthy JB, Simpson MA, Keely PJ, Guan JL, Tachibana K, Lim L, Manser E, Furcht LT, Iida J | title = Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas | journal = Nature Cell Biology | volume = 1 | issue = 8 | pages = 507–13 | date = December 1999 | pmid = 10587647 | doi = 10.1038/70302 }}
*{{cite journal | vauthors=Barritt DS, Pearn MT, Zisch AH |title=The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2. |journal=J. Cell. Biochem. |volume=79 |issue= 2 |pages= 213–24 |year= 2000 |pmid= 10967549 |doi=10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G |pmc=3501957|display-authors=etal}}
* {{cite journal | vauthors = Barritt DS, Pearn MT, Zisch AH, Lee SS, Javier RT, Pasquale EB, Stallcup WB | title = The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2 | journal = Journal of Cellular Biochemistry | volume = 79 | issue = 2 | pages = 213–24 | date = August 2000 | pmid = 10967549 | pmc = 3501957 | doi = 10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G }}
*{{cite journal | vauthors=Iida J, Pei D, Kang T |title=Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 18786–94 |year= 2001 |pmid= 11278606 |doi= 10.1074/jbc.M010053200 |display-authors=etal}}
* {{cite journal | vauthors = Iida J, Pei D, Kang T, Simpson MA, Herlyn M, Furcht LT, McCarthy JB | title = Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen | journal = The Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 18786–94 | date = June 2001 | pmid = 11278606 | doi = 10.1074/jbc.M010053200 }}
*{{cite journal | vauthors=Staub E, Hinzmann B, Rosenthal A |title=A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 114–8 |year= 2002 |pmid= 12220645 |doi=10.1016/S0014-5793(02)03195-2 }}
* {{cite journal | vauthors = Staub E, Hinzmann B, Rosenthal A | title = A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family | journal = FEBS Letters | volume = 527 | issue = 1-3 | pages = 114–8 | date = September 2002 | pmid = 12220645 | doi = 10.1016/S0014-5793(02)03195-2 }}
*{{cite journal | vauthors=Stegmüller J, Werner H, Nave KA, Trotter J |title=The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling. |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 3590–8 |year= 2003 |pmid= 12458226 |doi= 10.1074/jbc.M210010200 }}
* {{cite journal | vauthors = Stegmüller J, Werner H, Nave KA, Trotter J | title = The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling | journal = The Journal of Biological Chemistry | volume = 278 | issue = 6 | pages = 3590–8 | date = February 2003 | pmid = 12458226 | doi = 10.1074/jbc.M210010200 }}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
* {{cite journal | vauthors = Legg J, Jensen UB, Broad S, Leigh I, Watt FM | title = Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis | journal = Development | volume = 130 | issue = 24 | pages = 6049–63 | date = December 2003 | pmid = 14573520 | doi = 10.1242/dev.00837 }}
*{{cite journal | vauthors=Legg J, Jensen UB, Broad S |title=Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis. |journal=Development |volume=130 |issue= 24 |pages= 6049–63 |year= 2004 |pmid= 14573520 |doi= 10.1242/dev.00837 |display-authors=etal}}
* {{cite journal | vauthors = Ghali L, Wong ST, Tidman N, Quinn A, Philpott MP, Leigh IM | title = Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein | journal = The Journal of Investigative Dermatology | volume = 122 | issue = 2 | pages = 433–42 | date = February 2004 | pmid = 15009727 | doi = 10.1046/j.0022-202X.2004.22207.x }}
*{{cite journal | vauthors=Ghali L, Wong ST, Tidman N |title=Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein. |journal=J. Invest. Dermatol. |volume=122 |issue= 2 |pages= 433–42 |year= 2004 |pmid= 15009727 |doi= 10.1046/j.0022-202X.2004.22207.x |display-authors=etal}}
* {{cite journal | vauthors = Fukushi J, Makagiansar IT, Stallcup WB | title = NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin | journal = Molecular Biology of the Cell | volume = 15 | issue = 8 | pages = 3580–90 | date = August 2004 | pmid = 15181153 | pmc = 491820 | doi = 10.1091/mbc.E04-03-0236 }}
*{{cite journal | vauthors=Fukushi J, Makagiansar IT, Stallcup WB |title=NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. |journal=Mol. Biol. Cell |volume=15 |issue= 8 |pages= 3580–90 |year= 2005 |pmid= 15181153 |doi= 10.1091/mbc.E04-03-0236  | pmc=491820 }}
* {{cite journal | vauthors = Yang J, Price MA, Neudauer CL, Wilson C, Ferrone S, Xia H, Iida J, Simpson MA, McCarthy JB | title = Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms | journal = The Journal of Cell Biology | volume = 165 | issue = 6 | pages = 881–91 | date = June 2004 | pmid = 15210734 | pmc = 2172406 | doi = 10.1083/jcb.200403174 | url = http://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1000&context=biochemfacpub }}
*{{cite journal | vauthors=Yang J, Price MA, Neudauer CL |title=Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms. |journal=J. Cell Biol. |volume=165 |issue= 6 |pages= 881–91 |year= 2004 |pmid= 15210734 |doi= 10.1083/jcb.200403174  | pmc=2172406 |display-authors=etal}}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = July 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | vauthors=Colland F, Jacq X, Trouplin V |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148 |display-authors=etal}}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711–8 | date = September 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
*{{cite journal | vauthors=Suzuki Y, Yamashita R, Shirota M |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604  | pmc=515316 |display-authors=etal}}
* {{cite journal | vauthors = Makagiansar IT, Williams S, Dahlin-Huppe K, Fukushi J, Mustelin T, Stallcup WB | title = Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility | journal = The Journal of Biological Chemistry | volume = 279 | issue = 53 | pages = 55262–70 | date = December 2004 | pmid = 15504744 | doi = 10.1074/jbc.M411045200 }}
*{{cite journal | vauthors=Makagiansar IT, Williams S, Dahlin-Huppe K |title=Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55262–70 |year= 2005 |pmid= 15504744 |doi= 10.1074/jbc.M411045200 |display-authors=etal}}
* {{cite journal | vauthors = Petrini S, Tessa A, Stallcup WB, Sabatelli P, Pescatori M, Giusti B, Carrozzo R, Verardo M, Bergamin N, Columbaro M, Bernardini C, Merlini L, Pepe G, Bonaldo P, Bertini E | title = Altered expression of the MCSP/NG2 chondroitin sulfate proteoglycan in collagen VI deficiency | journal = Molecular and Cellular Neurosciences | volume = 30 | issue = 3 | pages = 408–17 | date = November 2005 | pmid = 16169245 | doi = 10.1016/j.mcn.2005.08.005 }}
*{{cite journal | vauthors=Petrini S, Tessa A, Stallcup WB |title=Altered expression of the MCSP/NG2 chondroitin sulfate proteoglycan in collagen VI deficiency. |journal=Mol. Cell. Neurosci. |volume=30 |issue= 3 |pages= 408–17 |year= 2006 |pmid= 16169245 |doi= 10.1016/j.mcn.2005.08.005 |display-authors=etal}}
* {{cite journal | vauthors = Brekke C, Lundervold A, Enger PØ, Brekken C, Stålsett E, Pedersen TB, Haraldseth O, Krüger PG, Bjerkvig R, Chekenya M | title = NG2 expression regulates vascular morphology and function in human brain tumours | journal = NeuroImage | volume = 29 | issue = 3 | pages = 965–76 | date = February 2006 | pmid = 16253523 | doi = 10.1016/j.neuroimage.2005.08.026 }}
*{{cite journal | vauthors=Brekke C, Lundervold A, Enger PØ |title=NG2 expression regulates vascular morphology and function in human brain tumours. |journal=NeuroImage |volume=29 |issue= 3 |pages= 965–76 |year= 2006 |pmid= 16253523 |doi= 10.1016/j.neuroimage.2005.08.026 |display-authors=etal}}
* {{cite journal | vauthors = Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD | title = Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry | journal = Journal of Proteome Research | volume = 4 | issue = 6 | pages = 2070–80 | year = 2006 | pmid = 16335952 | pmc = 1850943 | doi = 10.1021/pr0502065 }}
*{{cite journal  | vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 |display-authors=etal}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{UCSC gene info|CSPG4}}
* {{UCSC gene info|CSPG4}}
{{proteoglycans}}
{{proteoglycans}}


{{gene-15-stub}}
{{gene-15-stub}}

Revision as of 15:18, 4 November 2018

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Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene.[1][2][3]

CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.[3]

CSPG4/NG2 is also a hallmark protein of oligodendrocyte progenitor cells (OPCs)[4] and OPC dysfunction has been implicated as a candidate pathophysiological mechanism of familial schizophrenia.[5] A research group investigating the role of genetics in schizophrenia, reported, two rare missense mutations in CSPG4 gene, segregating within families (CSPG4A131T and CSPG4V901G mutations). The researchers also demonstrate that the induced pluripotent stem cells (iPSCs)-derived OPCs from CSPG4A131T mutation carriers exhibited abnormal post-translational processing, subcellular localization of the mutant NG2 protein, aberrant cellular morphology, and a decreased cell viability and myelination potential. In vivo diffusion tensor imaging of the brain of CSPG4A131T mutation carriers demonstrated a reduced white matter integrity compared to the unaffected sibling and matched general population controls.[6]

See also

References

  1. ↑ Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA (September 1996). "Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan". Proceedings of the National Academy of Sciences of the United States of America. 93 (18): 9710–5. doi:10.1073/pnas.93.18.9710. PMC 38494. PMID 8790396.
  2. ↑ Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S (May 2006). "Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells". Oncogene. 25 (20): 2873–84. doi:10.1038/sj.onc.1209319. PMID 16407841.
  3. ↑ 3.0 3.1 "Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4".
  4. ↑ Nishiyama A, Dahlin KJ, Prince JT, Johnstone SR, Stallcup WB (July 1991). "The primary structure of NG2, a novel membrane-spanning proteoglycan". The Journal of Cell Biology. 114 (2): 359–71. PMC 2289079. PMID 1906475.
  5. ↑ de Vrij FM, Bouwkamp CG, Gunhanlar N, Shpak G, Lendemeijer B, Baghdadi M, Gopalakrishna S, Ghazvini M, Li TM, Quadri M, Olgiati S, Breedveld GJ, Coesmans M, Mientjes E, de Wit T, Verheijen FW, Beverloo HB, Cohen D, Kok RM, Bakker PR, Nijburg A, Spijker AT, Haffmans PM, Hoencamp E, Bergink V, Vorstman JA, Wu T, Olde Loohuis LM, Amin N, Langen CD, Hofman A, Hoogendijk WJ, van Duijn CM, Ikram MA, Vernooij MW, Tiemeier H, Uitterlinden AG, Elgersma Y, Distel B, Gribnau J, White T, Bonifati V, Kushner SA (January 2018). "Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia". Molecular Psychiatry. doi:10.1038/s41380-017-0004-2. PMID 29302076.
  6. ↑ de Vrij FM, Bouwkamp CG, Gunhanlar N, Shpak G, Lendemeijer B, Baghdadi M, Gopalakrishna S, Ghazvini M, Li TM, Quadri M, Olgiati S, Breedveld GJ, Coesmans M, Mientjes E, de Wit T, Verheijen FW, Beverloo HB, Cohen D, Kok RM, Bakker PR, Nijburg A, Spijker AT, Haffmans PM, Hoencamp E, Bergink V, Vorstman JA, Wu T, Olde Loohuis LM, Amin N, Langen CD, Hofman A, Hoogendijk WJ, van Duijn CM, Ikram MA, Vernooij MW, Tiemeier H, Uitterlinden AG, Elgersma Y, Distel B, Gribnau J, White T, Bonifati V, Kushner SA (January 2018). "Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia". Molecular Psychiatry. doi:10.1038/s41380-017-0004-2. PMID 29302076.

Further reading

External links

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